Functional connectivity associated with hand shape generation: Imitating novel hand postures and pantomiming tool grips challenge different nodes of a shared neural network

Vingerhoets, Guy; Clauwaert, Amanda

doi:10.1002/hbm.22853

Cited by 27 publications

(20 citation statements)

References 64 publications

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“…The superior parietal cortex is involved in the central processes for writing [Planton et al, 2013; Sugihara et al, 2006; Sakurai et al, 2007], which is confirmed by the increase of activation in this area for the contrast writing versus zigzagging. The language related processes for writing refer to stored knowledge about orthographic and phonological processes gained over repetitive encounters [Vingerhoets and Clauwaert, 2015], independently from the effector used to write. This suggests that this area plays a minor role in specific motor processes during online execution of dominant handwriting.…”

Section: Discussionmentioning

confidence: 99%

Impairment of a parieto‐premotor network specialized for handwriting in writer's cramp

Gallea

Horovitz

Najee-ullah

et al. 2016

Human Brain Mapping

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Handwriting with the dominant hand is a highly skilled task singularly acquired in humans. This skill is the isolated deficit in patients with writer's cramp (WC), a form of dystonia with maladaptive plasticity, acquired through intensive and repetitive motor practice. When a skill is highly trained, a motor program is created in the brain to execute the same movement kinematics regardless of the effector used for the task. The task- and effector-specific symptoms in WC suggest that a problem particularly occurs in the brain when the writing motor program is carried out by the dominant hand. In the present MRI study involving 12 WC patients (with symptoms only affecting the right dominant hand during writing) and 15 age matched unaffected controls we showed that: (1) the writing program recruited the same network regardless of the effector used to write in both groups; (2) dominant handwriting recruited a segregated parieto-premotor network only in the control group; (3) local structural alteration of the premotor area, the motor component of this network, predicted functional connectivity deficits during dominant handwriting and symptom duration in the patient group. Dysfunctions and structural abnormalities of a segregated parieto-premotor network in WC patients suggest that network specialization in focal brain areas is crucial for well-learned motor skill.

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Section: Discussionmentioning

confidence: 99%

Impairment of a parieto‐premotor network specialized for handwriting in writer's cramp

Gallea

Horovitz

Najee-ullah

et al. 2016

Human Brain Mapping

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show abstract

“…This is unfortunate since RBD patients and right brain stimulations are often associated with defective imitation (De Renzi, 1980;Goldenberg, 1999;Stamenova et al, 2010). Further studies are now required to disentangle (Kubiak & Króliczak, 2016) (Adamovich, August, Merians, & Tunik, 2009) (Jackson, Meltzoff, & Decety, 2006) (Koski, Iacoboni, Dubeau, Woods, & Mazziotta, 2003) (Krüger et al, 2014) (Mühlau et al, 2005) (Montgomery, Isenberg, & Haxby, 2007) (Montgomery & Haxby, 2008) (Suchan, Melde, Herzog, Hömberg, & Seitz, 2008) (S Tanaka, Inui, Iwaki, Konishi, & Nakai, 2001) (Shigeki Tanaka & Inui, 2002) (Vingerhoets & Clauwaert, 2015) (Watanabe et al, 2011) (Mengotti, Corradi-Dell'Acqua, et al, 2013)…”

Section: Conclusion and Clinical Considerationsmentioning

confidence: 99%

Cerebral correlates of imitation of intransitive gestures: An integrative review of neuroimaging data and brain lesion studies

Lesourd

Osiurak

Baumard

et al. 2018

Neuroscience & Biobehavioral Reviews

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The aim of the present review is to investigate the cerebral correlates, more particularly the role of the parietal lobe, when imitating intransitive gestures, a task highly sensitive to apraxic errors. By providing an integrative review of functional imaging and brain lesion studies, we focused our attention on the meaning of gestures (meaningful and meaningless) and the body parts (finger and hand). We found that imitation of intransitive gestures is relying upon a bilateral brain network including fronto-parietal areas irrespective of meaning or body parts. Moreover, we observed that while imitation of meaningful and meaningless gestures is predominantly impacted following left parietal lesions, more brain areas are engaged during meaningless gesture imitation. Concerning body parts, whereas imitation of hand postures is relying upon the left parietal lobe (angular gyrus), imitation of finger postures is more likely to be impaired following lesions in the frontal lobe, insula and basal ganglia. These results question neuropsychological theories on apraxia and open promising avenues for a better understanding of apraxia.

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“…2018 ). Furthermore, an emerging literature demonstrates that there is increased functional connectivity between the left inferior parietal lobule and left posterior middle temporal gyrus when neurotypical participants gesture the use of tools ( Vingerhoets and Clauwaert 2015 ; Garcea et al. 2018 ; Hutchison and Gallivan 2018 ) and in resting-state fMRI ( Simmons and Martin 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Structural Disconnection of the Tool Use Network after Left Hemisphere Stroke Predicts Limb Apraxia Severity

Garcea

Greene

Grafton

et al. 2020

Cerebral Cortex Communications

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Producing a tool use gesture is a complex process drawing upon the integration of stored knowledge of tools and their associated actions with sensory-motor mechanisms supporting the planning and control of hand and arm actions. Understanding how sensory-motor systems in parietal cortex interface with semantic representations of actions and objects in the temporal lobe remains a critical issue, and is hypothesized to be a key determinant of the severity of limb apraxia, a deficit in producing skilled action after left hemisphere stroke. We used voxel-based and connectome-based lesion symptom mapping with data from 57 left hemisphere stroke participants to assess the lesion sites and structural disconnection patterns associated with poor tool use gesturing. We found that structural disconnection among the left inferior parietal lobule, lateral and ventral temporal cortex, and middle and superior frontal gyri predicted the severity of tool use gesturing performance. Control analyses demonstrated that reductions in right-hand grip strength were associated with motor system disconnection, largely bypassing regions supporting tool use gesturing. Our findings provide causal evidence that limb apraxia may arise, in part, from a disconnection between conceptual representations in the temporal lobe and mechanisms enabling skilled action production in the inferior parietal lobule.

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Functional connectivity associated with hand shape generation: Imitating novel hand postures and pantomiming tool grips challenge different nodes of a shared neural network

Cited by 27 publications

References 64 publications

Impairment of a parieto‐premotor network specialized for handwriting in writer's cramp

Impairment of a parieto‐premotor network specialized for handwriting in writer's cramp

Cerebral correlates of imitation of intransitive gestures: An integrative review of neuroimaging data and brain lesion studies

Structural Disconnection of the Tool Use Network after Left Hemisphere Stroke Predicts Limb Apraxia Severity

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