Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring

Steiner, Leonie; Homan, Stephanie; Everts, Regula; Federspiel, Andrea; Kamal, Sandeep; Rodríguez, Juan Antonio Delgado; Kornfeld, Salome; Slavova, Nedelina; Wiest, Roland; Kaelin‐Lang, Alain; Steinlin, Maja; Grunt, Sebastian

doi:10.1038/s41598-021-84671-2

Cited by 4 publications

(5 citation statements)

References 60 publications

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“…Thus, our modulation effect may reverse this trend. Indeed, high within-hemisphere FC may be responsible for motor function asymmetry ( 55 ). A reset of the unregular brain network may contribute to a restoration of better motor outcomes.…”

Section: Discussionmentioning

confidence: 99%

Cerebellum–Cerebrum paired target magnetic stimulation on balance function and brain network of patients with stroke: A functional near-infrared spectroscopy pilot study

Xia

Tang²,

Hu³

et al. 2022

Front. Neurol.

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Transcranial magnetic stimulation (TMS) modulation over the cerebellum, primary motor cortex, and supplementary motor cortex individually can improve the balance function of patients with stroke. However, whether their combination could have a better balance modulation effect is uncertain. Therefore, we hypothesized that performing TMS over a combination of these targets can regulate the balance function of patients with stroke. We compared the effects of one-session TMS on eye-open and eye-closed balance conditions in patients with stroke, using different target pairs of unilateral cerebellar (CB-single), cerebellar–primary motor cortex (CB-M1), and cerebellar–supplementary motor area (CB-SMA) targets. A total of 31 patients with stroke were enrolled and randomly divided into three groups to receive single sessions of intermittent theta burst stimulation each. Functional near-infrared spectrum data on resting and standing task states (eye-open and eye-closed) and center of pressure parameters (eye-open and eye-closed) were collected before and after the intervention. Compared with the results in the CB-single group, five intergroup differences in the changes in the center of pressure parameters in the CB-M1 group and two significant differences in the CB-SMA group were observed after one session of intermittent theta burst stimulation. In the CB-SMA group, 12 out of the 14 parameters improved significantly in the EC condition after the intervention. Meanwhile, the functional near-infrared spectrum results showed that the CB-SMA group exhibited a significant inhibitory pattern in the resting-state functional connectivity, which was not observed in the other two groups. In conclusion, we believe that paired targeting of the CB-SMA can reshape the brain network and improve the balance function of patients with stroke.

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Section: Discussionmentioning

confidence: 99%

Cerebellum–Cerebrum paired target magnetic stimulation on balance function and brain network of patients with stroke: A functional near-infrared spectroscopy pilot study

Xia

Tang²,

Hu³

et al. 2022

Front. Neurol.

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“… 65 , 76 The question whether the motor networks is affected by a hemiparesis, was addressed in one of our previous studies. 40 We investigated functional connectivity in paediatric patients after stroke with hemiparesis compared with patients with a good clinical outcome and healthy controls. Patients with hemiparesis showed lower interhemispheric connectivity strength in the motor network compared to patients with good clinical outcome and controls.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with hemiparesis showed lower interhemispheric connectivity strength in the motor network compared to patients with good clinical outcome and controls. 40 …”

Section: Discussionmentioning

confidence: 99%

“…Further, patients with hemiparesis after paediatric AIS showed reduced interhemispheric connectivity strength in the motor network compared to patients without hemiparesis and healthy controls. 40 In studies that compared healthy controls to children with perinatal AIS, both weaker and stronger functional connectivity of the primary motor cortex to other brain regions was found. 38 …”

Section: Introductionmentioning

confidence: 99%

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Cognitive outcome is related to functional thalamo-cortical connectivity after paediatric stroke

Steiner

Federspiel

Slavova

et al. 2022

Brain Communications

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The thalamus has complex connections with the cortex and is involved in various cognitive processes. Despite increasing interest in the thalamus and the underlying thalamo-cortical interaction, little is known about thalamo-cortical connections after pediatric arterial ischemic stroke. Therefore, the aim of this study was to investigate thalamo-cortical connections and their association with cognitive performance after arterial ischemic stroke. Twenty patients in the chronic phase after pediatric arterial ischemic stroke (≥ 2 years after diagnosis, diagnosed <16 years; aged 5–23 years, mean 15.1 years) and twenty healthy controls matched for age and sex were examined in a cross-sectional study design. Cognitive performance (selective attention, inhibition, working memory, and cognitive flexibility) was evaluated using standardized neuropsychological tests. Resting-state functional magnetic resonance imaging was used to examine functional thalamo-cortical connectivity. Lesion masks were integrated in the preprocessing pipeline to ensure that structurally damaged voxels did not influence functional connectivity analyses. Cognitive performance (selective attention, inhibition and working memory) was significantly reduced in patients compared to controls. Network analyses revealed significantly lower thalamo-cortical connectivity for the motor, auditory, visual, default mode network, salience, left/right executive and dorsal attention network in patients compared to controls. Interestingly, analyses revealed as well higher thalamo-cortical connectivity in some subdivisions of the thalamus for the default mode network (medial nuclei), motor (lateral nuclei), dorsal attention (anterior nuclei), and the left executive network (posterior nuclei) in patients compared to controls. Increased and decreased thalamo-cortical connectivity strength within the same networks was, however, found in different thalamic sub-divisions. Thus, alterations in thalamo-cortical connectivity strength after pediatric stroke seem to point in both directions, with stronger as well as weaker thalamo-cortical connectivity in patients compared to controls. Multivariate linear regression, with lesion size and age as covariates, revealed significant correlations between cognitive performance (selective attention, inhibition, and working memory) and the strength of thalamo-cortical connectivity in the motor, auditory, visual, default mode network, posterior default mode network, salience, left/right executive, and dorsal attention network after childhood stroke. Our data suggest that the interaction between different sub-nuclei of the thalamus and several cortical networks relates to post-stroke cognition. The variability in cognitive outcomes after pediatric stroke might partly be explained by functional thalamo-cortical connectivity strength.

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“…The latter is important, as it seems that children with AIS who do not develop a hemiparesis may also have difficulties in finding strategies to use their upper limbs efficiently to manage daily activities, which may also affect their quality of life 7 . Although we controlled for lesion size in our analyses, we know that other factors like lesion location 37 and brain functional networks 38,39 play an important role. It is plausible that children with AIS and without hemiparesis had their lesion mostly located in other regions that affected specific brain networks (e.g.…”

Section: Discussionmentioning

confidence: 99%

Participation after childhood stroke: Is there a relationship with lesion size, motor function and manual ability?

Simón-Martínez

Kamal

Frickmann

et al. 2021

European Journal of Paediatric Neurology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring

Cited by 4 publications

References 60 publications

Cerebellum–Cerebrum paired target magnetic stimulation on balance function and brain network of patients with stroke: A functional near-infrared spectroscopy pilot study

Cerebellum–Cerebrum paired target magnetic stimulation on balance function and brain network of patients with stroke: A functional near-infrared spectroscopy pilot study

Cognitive outcome is related to functional thalamo-cortical connectivity after paediatric stroke

Participation after childhood stroke: Is there a relationship with lesion size, motor function and manual ability?

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