Functional components in sweetpotato and their genetic improvement

Tanaka, Masaru; Ishiguro, Koji; Oki, Tomoyuki; Okuno, Sachiko

doi:10.1270/jsbbs.16125

Cited by 71 publications

(57 citation statements)

References 70 publications

(70 reference statements)

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“…Approach through the mechanism of cancer cell apoptosis and the empowerment of natural materials to be one promising alternative, such as Ayamurasaki and Simon extract. (3,4) Two varieties of sweet potato (Ipomoea batatas L.) are reported to contain caffeic acid compounds that proved to have the ability to inhibit osteoclastogenesis. (4)(5)(6) Caffeic acid significantly reduces the activity of nuclear factor κB (NFκB), a cell signaling pathway involved in osteoclastogenesis (5), in which NFκB inhibition can cause tumor cells to stop proliferating or becoming more sensitive to the actions of anti-tumor agents.…”

Section: Introductionmentioning

confidence: 99%

Caspase Inhibitor Diminishes Caffeic Acid-induced Apoptosis in Osteosarcoma Cells

et al. 2017

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B ACKGROUND:Caffeic acid has been shown to induce apoptosis in MG63 osteosarcoma cells. Along with the apoptotic induction, caffeic acid was shown to activate caspase-8, -9 and -3. However, the role of caspase in mediating caffeic acid-induced apoptosis in MG63 cells are not clear yet. In this study, caspase role was further investigated by inhibiting caspase activity in the caffeic acid-induced apoptosis system in the MG63 cells. METHODS:MG63 cells were cultured, starved, pretreated with/without Z-VAD FMK and treated with/without 10 µg/mL caffeic acid. To quantify the number of apoptotic MG63 cells, Sub-G1 method was performed. The caffeic acid-induced apoptotic morphology was confirmed with 4',6-diamidino-2-phenylindole (DAPI) staining and Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Meanwhile, to detect apoptotic underlying mechanism, immunoblotting was performed to detect caspase-8, -9 and -3. RESULTS:The MG63 cells were significantly induced into apoptosis with the treatment of 10 µg/mL caffeic acid for 48 hours. However, pretreatment of 100 µM Z-VAD-FMK, a pan caspase inhibitor, for 2 hours, the percentage of apoptotic MG63 cells was significantly diminished. The apoptotic phenomenon induced by caffeic acid as well as the inhibition of Z-VAD-FMK were confirmed by DAPI staining and TUNEL assay. Cleaved caspase-8, -9 and -3 were formed markedly upon the treatment of caffeic acid. Pretreatment of 100 µM Z-VAD-FMK could inhibit the cleaved caspase-8, -9 and -3. CONCLUSION:Taken together, caffeic acid has the potential to induce apoptosis in MG63 cells, specifically through the caspase signaling pathway. KEYWORDS

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Section: Introductionmentioning

confidence: 99%

Caspase Inhibitor Diminishes Caffeic Acid-induced Apoptosis in Osteosarcoma Cells

et al. 2017

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“…However, there are variations in size, the colour of flesh (white, orange, cream, yellow, and purple) and skin colour [28] among the various sweet potato cultivars globally. The anthocyanin contents in purple-fleshed sweet potato are relatively higher compared to other flesh colours (white, cream, yellow or orange) with little or no anthocyanins [8]. Purple-fleshed sweet potato has gained recognition by dint of their copious physiological properties including antioxidative, antimutagenic, and antihypertensive activities [29].…”

Section: Introductionmentioning

confidence: 99%

Structure, Functions and Biosynthetic Pathway of Naturally Occurring Anthocyanin in Sweet Potato - A Review

Amoanimaa-Dede¹,

Zhu²,

Kyereko³

et al. 2019

J Plant Biochem Physiol

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Sweet potato (Ipomoea batatas (L.) Lam.) has several phytochemicals including anthocyanin that provide many special health-promoting functions as well as other functional components. Sweet potato is thought to be a health-giving food owing to the numerous diversities of natural products, especially antioxidants. Anthocyanins are natural hydrosoluble pigments which give the purple, blue and red colouration evident in fruits, leaves, flowers, and storage organs. Anthocyanins are beneficial to human health due to their potent antioxidative properties which protect against several chronic disorders, thus a valuable constituent in the human diet. The pathway for biosynthesis of anthocyanin has been clearly defined with its key regulatory genes identified and segregated in diverse species.Cyanidin or Peonidin 3-sophoroside-5-glucoside with associated acylated derivate are the two primary anthocyanins identified in purple-fleshed sweet potato. Anthocyanins in sweet potato are of great importance to plants, animals, humans and possess scientific benefits as well. This article provides a summary of current findings on the function, structure, and biosynthesis of anthocyanin in sweet potato.

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“…In Japan, sweetpotato is grown in regions below about 36 o 4'N latitude to produce starch, a distilled alcoholic drink, processed foods, natural color pigment and edible food. Sweetpotato has a number of health benefits due to its content of anthocyanins, carotenoids, polyphenolics, vitamins, minerals and dietary fibers [2].…”

Section: Introductionmentioning

confidence: 99%

“…Purple sweetpotatoes, which contain anthocyanins in their flesh, have been developed over the last two decades [2]. Their production has gradually increased in the south of Japan and processed foods containing purple sweetpotato have been developed and become widely available since the first variety, Ayamusasaki, was released [3].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Anthocyanin and Polyphenolics in Purple Sweetpotato (<em>Ipomoea batatas</em> L.) Grown in Different Locations in Japan

Ishiguro¹,

Kuranouchi²,

Yu³

et al. 2017

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The health benefits of purple sweetpotato, which is used as an edible food in its natural state and in processed foods and as a natural color pigment, have been recognized. In Japan, sweetpotato has been economically produced in regions below 36°4′N latitude, however, cultivation areas are beginning to expand further north. The anthocyanin and polyphenolics in purple sweetpotatoes cultivated in different locations; I (42°92′ N, 143°04′ E), II (35°99′ N, 140°01′ E), and III (31°72′ N, 131°03′ E), were compared over two years. Total anthocyanin and polyphenolic contents in purple sweetpotatoes tended to be high in location I. Their contents significantly differed over the two years in locations I and III and was dependent on temperature during cultivation. The anthocyanin and polyphenolic compositions differed between locations. The peonidin/cyanidin ratios were higher in location III compared with I and II in all varieties. The relative amount of chlorogenic acid was higher in location I, while the amount of 3,4- and 4,5-dicaffeoyolquinic acids were higher in location III, suggesting that the variability of the anthocyanin and polyphenolic content and composition was dependent on cultivation conditions. This study suggested that northern areas in Japan are an alternative production area and may yield higher amounts of anthocyanin and polyphenolics.

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Functional components in sweetpotato and their genetic improvement

Cited by 71 publications

References 70 publications

Caspase Inhibitor Diminishes Caffeic Acid-induced Apoptosis in Osteosarcoma Cells

Caspase Inhibitor Diminishes Caffeic Acid-induced Apoptosis in Osteosarcoma Cells

Structure, Functions and Biosynthetic Pathway of Naturally Occurring Anthocyanin in Sweet Potato - A Review

Comparison of Anthocyanin and Polyphenolics in Purple Sweetpotato (<em>Ipomoea batatas</em> L.) Grown in Different Locations in Japan

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