Functional characterization of two different Kupffer cell populations of normal rat liver

Armbrust, Thomas; Ramadori, Giuliano

doi:10.1016/s0168-8278(96)80212-1

Cited by 67 publications

(69 citation statements)

References 24 publications

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“…a p < 0.05 as compared to healthy controls, b p< 0.05 compared to KC from cirrhotic animals. 22], we observed in our healthy controls that the number of ED-1 positive cells much lower than that ED-2 positive ones. In contrast, in animals with liver steato-necrosis as well as with cirrhosis, the number of ED-1 positive cells was dramatically increased, suggesting a recruitment of monocytes during both acute and chronic liver diseases.…”

Section: Eicosanoid Synthesismentioning

confidence: 60%

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Reactive oxygen intermediates and eicosanoid production by Kupffer cells and infiltrated macrophages in acute and chronic liver injury induced in rats by CCl 4

Alric

Orfila

Carrère

et al. 2000

Inflammation Research

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These results suggest an influx of monocytes into the liver during acute and chronic injury induced by CCl4. Functional changes of this inflammatory infiltrate have been demonstrated with an increase of ROI production only in the early stage of liver injury whereas a rise in KC leukotriene production and an imbalance between cytoprotective and cytotoxic prostanoids were observed at all stages of liver disease.

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Section: Eicosanoid Synthesismentioning

confidence: 60%

“…HPLC analysis was performed after eicosanoid extraction on Bond Elut C18 columns as described previously [6,7,22]. PG and LT after extraction were resuspended in acetonitrile-water-acetic acid (35:65:0.6, v/v/v) and subjected to reverse-phase HPLC.…”

Section: Extraction and Analysis Of Extracellular Aa Metabolitesmentioning

confidence: 99%

Reactive oxygen intermediates and eicosanoid production by Kupffer cells and infiltrated macrophages in acute and chronic liver injury induced in rats by CCl 4

Alric

Orfila

Carrère

et al. 2000

Inflammation Research

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“…Fluiter et al (1998) reported that estrogen treatment of rats is associated with increased levels of expression of SR-BI in Kupffer cells. Kupffer cells were identified using ED1, a Kupffer cell-specific antigen (Armbrust & Ramadori 1996) (Fig. 2E, F, I and J).…”

Section: High-dose Estrogen Treatment Results In Decreased Sr-bi Exprmentioning

confidence: 99%

“…Slides were blocked with universal blocking agent (Biogenex) and incubated with IgG-SRBI or with a mouse anti-rat ED1 antibody (Serotec, Raleigh, NC, USA) overnight. ED1 is an antigen expressed on Kupffer cells but not hepatocytes (Armbrust & Ramadori 1996). Sections were rinsed and incubated with biotinylated anti-rabbit or anti-mouse IgG (Jackson Immunochemical, West Grove, PA, USA) for 1 h, and rinsed again prior to addition of streptavidinconjugated horseradish peroxidase (Research Genetics, Huntsville, AL, USA).…”

Section: Immunocytochemistrymentioning

confidence: 99%

Effect of estrogen on scavenger receptor BI expression in the rat

Stangl

Graf²,

Yu³

et al. 2002

Journal of Endocrinology

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High-dose 17 -ethinyl estradiol treatment is associated with increased adrenal and decreased hepatic levels of scavenger receptor class B type 1 (SR-BI) in rats. In this paper we explored the mechanisms responsible for the differential regulation of SR-BI by estrogen in these two tissues. Previously it was shown that estrogen-treated rats are profoundly hypolipidemic due to increased hepatic low density lipoprotein receptor (LDLR) activity, and that this effect is not maintained with hypophysectomy. To determine if the reduction in hepatic SR-BI was a direct or indirect effect of estrogen, we treated hypophysectomized rats with high-dose estrogen; the levels of SR-BI expression did not change in the livers or adrenals of these animals. To determine if the absence of response to estrogen in the adrenals of hypophysectomized animals was due to the absence of adrenocorticotropic hormone (ACTH), we examined the effect of estrogen treatment on SR-BI expression in animals treated with dexamethasone, which inhibits endogenous ACTH production. The administration of dexamethasone completely inhibited the increase in SR-BI expression in the adrenals of estrogentreated rats. From these studies we conclude that estrogen does not have a direct effect on SR-BI expression in either the liver or the adrenals. In the liver, the decrease in SR-BI is dependent on the estrogen-induced increase in LDLR activity, and in the adrenal glands, ACTH is required for the estrogen-associated increase in expression of SR-BI.

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“…However, the highest levels of ApoE mRNA are found in the liver parenchymal cells and the second highest are found in the astrocytes in the brain. Furthermore, ApoE is also produced by macrophages from the liver, lungs, and spleen (12,26). In the absence of lipids, ApoE self-associates to form tetramers over a wide concentration range (580).…”

Section: Apolipoprotein Ementioning

confidence: 99%

Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock

2003

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Bacterial sepsis and septic shock result from the overproduction of inflammatory mediators as a consequence of the interaction of the immune system with bacteria and bacterial wall constituents in the body. Bacterial cell wall constituents such as lipopolysaccharide, peptidoglycans, and lipoteichoic acid are particularly responsible for the deleterious effects of bacteria. These constituents interact in the body with a large number of proteins and receptors, and this interaction determines the eventual inflammatory effect of the compounds. Within the circulation bacterial constituents interact with proteins such as plasma lipoproteins and lipopolysaccharide binding protein. The interaction of the bacterial constituents with receptors on the surface of mononuclear cells is mainly responsible for the induction of proinflammatory mediators by the bacterial constituents. The role of individual receptors such as the toll-like receptors and CD14 in the induction of proinflammatory cytokines and adhesion molecules is discussed in detail. In addition, the roles of a number of other receptors that bind bacterial compounds such as scavenger receptors and their modulating role in inflammation are described. Finally, the therapies for the treatment of bacterial sepsis and septic shock are discussed in relation to the action of the aforementioned receptors and proteins

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Functional characterization of two different Kupffer cell populations of normal rat liver

Cited by 67 publications

References 24 publications

Reactive oxygen intermediates and eicosanoid production by Kupffer cells and infiltrated macrophages in acute and chronic liver injury induced in rats by CCl 4

Reactive oxygen intermediates and eicosanoid production by Kupffer cells and infiltrated macrophages in acute and chronic liver injury induced in rats by CCl 4

Effect of estrogen on scavenger receptor BI expression in the rat

Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock

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