Functional characterization of the translationally controlled tumor protein (TCTP) gene associated with growth and defense response in cabbage

Cao, Bihao; Lu, Yu; Chen, Guoju; Liu, Jing

doi:10.1007/s11240-010-9769-6

Cited by 40 publications

(28 citation statements)

References 35 publications

(41 reference statements)

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“…This is consistent with the observation that overexpression of TCTP in Arabidopsis resulted in increased drought tolerance of the plants (Kim et al 2012a). Moreover, in the cabbage (Brassica oleracea), TCTP was found to be involved in maintaining tolerance to heat, cold and to salt stresses (Cao et al 2010). A study on TCTP from cassava (Manihot esculenta Crantz) reported that the promoter region of the TCTP gene harbours regulatory elements responsive to sodium chloride and to pathogen infection, and that expression of this gene in bacteria conferred a protective effect against salt stress (Santa Brigida et al 2014).…”

Section: Involvement In Cellular Stress Responsessupporting

confidence: 89%

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

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The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in many fundamental cell biological and disease processes. It was first discovered about 35 years ago, and it took an extended period of time for its multiple functions to be revealed, and even today we do not yet fully understand all the details. Having witnessed most of this history, in this chapter, I give a brief overview and review the current knowledge on the structure, biological functions, disease involvements and cellular regulation of this protein. TCTP is able to interact with a large number of other proteins and is therefore involved in many core cell biological processes, predominantly in the response to cellular stresses, such as oxidative stress, heat shock, genotoxic stress, imbalance of ion metabolism as well as other conditions. Mechanistically, TCTP acts as an anti-apoptotic protein, and it is involved in DNA-damage repair and in cellular autophagy. Thus, broadly speaking, TCTP can be considered a cytoprotective protein. In addition, TCTP facilitates cell division through stabilising the mitotic spindle and cell growth through modulating growth signalling pathways and through its interaction with the proteosynthetic machinery of the cell. Due to its activities, both as an anti-apoptotic protein and in promoting cell growth and division, TCTP is also essential in the early development of both animals and plants. Apart from its involvement in various biological processes at the cellular level, TCTP can also act as an extracellular protein and as such has been involved in modulating whole-body defence processes, namely in the mammalian immune system. Extracellular TCTP, typically in its dimerised form, is able to induce the release of cytokines and other signalling molecules from various types of immune cells. There are also several examples, where TCTP was shown to be involved in antiviral/antibacterial defence in lower animals. In plants, the protein appears to have a protective effect against phytotoxic stresses, such as flooding, draught, too high or low temperature, salt stress or exposure to heavy metals. The finding for the latter stress condition is corroborated by earlier reports that TCTP levels are considerably up-regulated upon exposure of earthworms to high levels of heavy metals. Given the involvement of TCTP in many biological processes aimed at maintaining cellular or whole-body homeostasis, it is not surprising that dysregulation of TCTP levels may promote a range of disease processes, foremost cancer. Indeed a large body of evidence now supports a role of TCTP in at least the most predominant types of human cancers. Typically, this can be ascribed to both the anti-apoptotic activity of the protein and to its function in promoting cell growth and division. However, TCTP also appears to be involved in the later stages of cancer progression, such ...

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Section: Involvement In Cellular Stress Responsessupporting

confidence: 89%

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

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“…It has a prevalent role in growth and development of both plants [48,50] and animals [15–17]. It is interesting to note that the TCTP protein sequence of E .…”

Section: Discussionmentioning

confidence: 99%

Function of translationally controlled tumor protein (TCTP) in Eudrilus eugeniae regeneration

et al. 2017

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TCTP (Translationally Controlled Tumour Protein) is a multifunctional protein that plays a role in the development, immune system, tumour reversion, and maintenance of stem cells. The mRNA of the Tpt1 gene is over-expressed during liver regeneration. But, the function of the protein in regeneration is not known. To study the role of the protein in regeneration, the earthworm Eudrilus eugeniae was chosen. First, the full length cDNA of the Tpt1 gene was sequenced. The size of the cDNA is 504 bp and the protein has 167 amino acids. The highest level of TCTP expression was documented in the worm after three days of regeneration. The protein was found to be expressed specifically in the epithelial layer of the skin. During regeneration, the protein expression was found to be the highest at the tip of blastema. The pharmacological suppression of TCTP using nutlin-3 and TCTP RNAi experiments resulted in the failure of the regeneration process. The suppression of TCTP caused the arrest of proliferation in posterior amputated worms. The severe cell death was documented in the amputated region of nutlin-3 injected worm. The silencing of TCTP has blocked the modification of clitellar segments. The experiments confirm that TCTP has major functions in the upstream signalling of cell proliferation in the early regeneration process in E. eugeniae.

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“…Induction of TCTP synthesis under heat stress conditions was originally noted in parasitic organisms, such as Trichinella [94,95] and Schistosoma [41]. A recent study investigated the importance of TCTP for stress tolerance of the cabbage, Brassica oleracea, and found that silencing of the TCTP gene by RNAi led to reduced vegetative growth rate and decreased tolerance of cold, high temperature and salt stresses by the cabbage plants [96].…”

Section: Cell Physiological Conditions Resulting In Regulation Of Tctmentioning

confidence: 99%

Cellular Function and Regulation of the Translationally Controlled Tumour Protein TCTP

Bommer¹

2012

TOALLJ

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Abstract:The 'translationally controlled tumour protein' TCTP was originally discovered 30 years ago by researchers interested in proteins regulated at the translational level. Cloning and sequencing confirmed the conservation of this protein among all eukaryotic kingdoms, but did not reveal any functional clue, and TCTP was listed in the databases as a 'family' of its own. The functional characterisation of this protein extended over more than a decade, leading to a plethora of individual functions and interactions that have been ascribed to this protein. A major addition to the functional characterisation of TCTP was the identification in 1995 of its histamine releasing factor (HRF) activity in allergic conditions, which for the first time described an extracellular activity for TCTP in human disease. This triggered a host of additional publications aimed at characterising this HRF activity, which are discussed in other articles of this issue. Another milestone in the elucidation of TCTP's function was the demonstration of its anti-apoptotic activity in 2001. Evidence is also accumulating for a role of TCTP in the cell cycle and in early development. This article provides an overview of the main cellular activities of TCTP. The second part will summarise our current knowledge on the mechanisms involved in regulating intracellular TCTP levels.

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Functional characterization of the translationally controlled tumor protein (TCTP) gene associated with growth and defense response in cabbage

Cited by 40 publications

References 35 publications

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Function of translationally controlled tumor protein (TCTP) in Eudrilus eugeniae regeneration

Cellular Function and Regulation of the Translationally Controlled Tumour Protein TCTP

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