Functional characterization of the evolutionarily preserved mitochondrial antiviral signaling protein (MAVS) from rock bream, Oplegnathus fasciatus

Kasthuri, Saranya Revathy; Wan, Qiang; Whang, Ilson; Lim, Bong-Soo; Yeo, Sang-Yeob; Choi, Cheol Young; Lee, Jehee

doi:10.1016/j.fsi.2014.07.034

Cited by 23 publications

(16 citation statements)

References 43 publications

(54 reference statements)

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“…EsIPS-1 transcripts were detected in all examined tissues, which suggests its possible role in innate immunity. Similar findings were reported in grass carp , Japanese flounder (Simora et al, 2010) and rock bream (Kasthuri et al, 2014). However, E. suratensis showed the highest basal expression in gill tissue whereas the spleen showed the highest expression in grass carp and Japanese flounder (Simora et al, 2010;Su et al, 2011).…”

Section: Discussionsupporting

confidence: 86%

“…However, E. suratensis showed the highest basal expression in gill tissue whereas the spleen showed the highest expression in grass carp and Japanese flounder (Simora et al, 2010;Su et al, 2011). In rock bream, the highest expression level was detected in the blood (Kasthuri et al, 2014).…”

Section: Discussionmentioning

confidence: 93%

“…However, although in Japanese flounder, kidney leukocytes stimulated in vitro and in vivo with VHSV and poly I:C showed no significant up-regulation of IPS (Simora et al, 2010), in zebrafish, it has been reported that IPS-1 specifically gets up-regulated in response to poly I:C at 42 hpi (Fan et al, 2008). Further in poly I:Cchallenged rock seabream, the temporal expression of mitochondrial antiviral signalling protein (MAVS) was significantly up-regulated in the immune related tissues and lymphoid organs (Kasthuri et al, 2014). These reports elucidate that IPS plays a vital role in antiviral immunity in conjunction with MDA5.…”

Section: Discussionmentioning

confidence: 95%

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Molecular cloning, characterisation and expression analysis of melanoma differentiation associated gene 5 (MDA5) of green chromide, Etroplus suratensis

Bhat

Paria

Deepika

et al. 2015

Gene

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 95%

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Molecular cloning, characterisation and expression analysis of melanoma differentiation associated gene 5 (MDA5) of green chromide, Etroplus suratensis

Bhat

Paria

Deepika

et al. 2015

Gene

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“…NLRs pathway is also involved in the RIPK2 and MAVS response to viral pathogens (Zou et al., ). MAVS orthologues have been identified and cloned in several teleost species (Biacchesi et al., ; Chen et al., ; Kasthuri et al., ; Lauksund, Svingerud, Bergan, & Robertsen, ; Lu, Li, Lu, & Zhang, ; Shen et al., ; Xiang et al., ; Zhang et al., ), including zebrafish and crucian carp. Teleost MAVS plays a small, but indispensable role in the NLR‐ or RLR‐mediated signalling pathway; like its mammalian orthologues, teleost MAVS contains a C‐terminal CARD domain and a transmembrane region at the N‐terminus.…”

Section: Teleost Nlr Signalling Pathwaysmentioning

confidence: 99%

Nucleotide‐binding and oligomerization domain (NOD)‐like receptors in teleost fish: Current knowledge and future perspectives

Zhang

Gao

et al. 2018

Journal of Fish Diseases

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Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are a group of intracellular pathogen recognition receptors (PRRs) that play key roles in pathogen recognition and subsequent activation of innate immune signalling pathways. Expressions of several NLR subfamily members, including NOD1, NOD2, NLR-C3, NLR-C5 and NLR-X1 have been reported in many different teleost fish species. These receptors are activated by a variety of ligands, including lipopolysaccharides (LPS), peptidoglycans (PGN) and polyinosinic-polycytidylic acid [Poly(I:C)]. Synthetic dsRNA and bacterial or viral infections are known to stimulate these receptors both in vitro and in vivo. In this review, we focus on the identification, expression and function of teleost NLRs in response to bacterial or viral pathogens. Additionally, NLR ligand specificity and signalling pathways involved in the recognition of bacterial or viral stimuli are also summarized. This review focuses on current knowledge in this area and provides future perspectives regarding topics in need of additional investigation. Understanding the response of innate immune system to bacterial or viral infections in diverse species could inform the development of more effective therapies and vaccines.

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“…Finally, the production of type I interferon (INF‐I) and proinflammatory factor would clear HCV . Therefore, we speculated that DEAD (Asp‐Glu‐Ala‐Asp) box protein 58 (DDX58) and interferon‐induced helicase C domain‐containing protein 1 (IFIH1), as important members of RLRs, play an important role in influencing the susceptibility and clinical outcome of HCV infection …”

Section: Introductionmentioning

confidence: 99%

Genetic variants in IFIH1 and DDX58 influence hepatitis C virus clearance in Chinese Han population

Zhu¹,

Zhuo

Yue

et al. 2019

Journal of Medical Virology

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Aims To investigate the association between two RIG‐I‐like receptor gene polymorphisms and hepatitis C virus (HCV) infection in Chinese Han population. Methods The current study genotyped two selected SNPs (IFIH1 rs3747517 and DDX58 rs9695310) using TaqMan allelic discrimination assay to assess their association with the susceptibility and clinical outcome of HCV infection among 3065 participants (1545 non‐HCV infection individuals, 568 spontaneous HCV clearance cases, and 952 persistent infection patients). Results IFIH1 rs3747517 (dominant model: Adjusted odds ratio [OR] = 1.34, 95% confidence interval [CI] = 1.07‐1.68; P = 0.009) and DDX58 rs9695310 (dominant model: Adjusted OR = 1.43, 95% CI = 1.15‐1.78; P = 0.001) were associated with chronic hepatitis C (CHC). And the risk of CHC increased when people were carrying more unfavorable rs3747517‐GA/AA and rs9695310‐GC/CC genotypes from zero to two with the chronic rates of 56.72%, 59.38%, and 69.01%, respectively (Ptrend < 0.001). Conclusion Genetic variations at IFIH1 rs3747517 and DDX58 rs9695310 were independent predictors of chronic hepatitis C in Chinese Han population.

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Functional characterization of the evolutionarily preserved mitochondrial antiviral signaling protein (MAVS) from rock bream, Oplegnathus fasciatus

Cited by 23 publications

References 43 publications

Molecular cloning, characterisation and expression analysis of melanoma differentiation associated gene 5 (MDA5) of green chromide, Etroplus suratensis

Molecular cloning, characterisation and expression analysis of melanoma differentiation associated gene 5 (MDA5) of green chromide, Etroplus suratensis

Nucleotide‐binding and oligomerization domain (NOD)‐like receptors in teleost fish: Current knowledge and future perspectives

Genetic variants in IFIH1 and DDX58 influence hepatitis C virus clearance in Chinese Han population

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