Abstract:The hypothesis that increased heart muscle contractility leads to HCM and reduced contractility leads to DCM is based mainly on studies on myosin motor proteins. This hypothesis predicts that a change in cardiac actin (ACTC) may impact muscle contractility. To test this prediction, we determined the interactions between myosin and 8 of 16 ACTC mutant proteins that are known to cause hypertrophic or dilated cardiomyopathy. R312H showed a decreased actin-activated S1 ATPase rate (13.150.63 mM/min) compared to WT… Show more
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