Functional characteristics of the midbrain periaqueductal gray

Behbehani, Michael M.

doi:10.1016/0301-0082(95)00009-k

Cited by 785 publications

(579 citation statements)

References 251 publications

Supporting

Mentioning

529

Contrasting

Unclassified

Order By: Relevance

“…Morphine-induced reward, locomotion, thermal antinociceptive tolerance and physical dependence are each virtually ablated in homozygous receptor knockout mice and are thus strikingly receptor dependent. Even such strikingly receptor dependent effects, however, are likely to involve distinct brain circuits (Behbehani 1995). These circuits contain distinct neuronal populations that express differing densities of receptors (Moriwaki et al 1996), the Gi and Go class guanine nucleotide binding proteins activated by agonist-occupied receptors (Reisine et al 1996), opiate-modulated second messenger systems (Childers 1993), opiate-modulated potassium (Kovoor et al 1995) and calcium channels (North 1993), and other effector systems.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

μ Opiate Receptor Gene Dose Effects on Different Morphine Actions Evidence for Differential in vivo μ Receptor Reserve

Sora¹,

Elmer

Funada

et al. 2001

Neuropsychopharmacology

133

118

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Neurons expressing receptors are found at many different levels of the neuraxis (Moriwaki et al 1996). Many of these localizations can be correlated with some of the multiple actions of opiate drugs (Behbehani 1995).…”

mentioning

confidence: 99%

μ Opiate Receptor Gene Dose Effects on Different Morphine Actions Evidence for Differential in vivo μ Receptor Reserve

Sora¹,

Elmer

Funada

et al. 2001

Neuropsychopharmacology

133

118

View full text Add to dashboard Cite

show abstract

“…Those regions of the PAG further send descending neuronal projections to the medulla (Hudson and Lumb, 1996;Odeh and Antal, 2001) in regulating pain and autonomic activity (McGaraughty et al, 2003;Tjen-A-Looi et al, 2006;Verberne and Guyenet, 1992). For example, activation of the dl-PAG contributes to an increase in arterial blood pressure and antinociception (Bandler et al, 1991;Behbehani, 1995).…”

Section: Introductionmentioning

confidence: 99%

Prostaglandin E2 (PGE2) inhibits glutamatergic synaptic transmission in dorsolateral periaqueductal gray (dl-PAG)

Xing

2007

Brain Research

View full text Add to dashboard Cite

The purpose of this study was to determine the role of prostaglandin E 2 (PGE 2 ) in modulating neuronal activity of the dorsolateral periaqueductal gray (dl-PAG) through excitatory and inhibitory synaptic inputs. First, whole cell voltage-clamp recording was performed to obtain excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) of the dl-PAG neurons. Our results show that PGE 2 significantly decreased the frequency of miniature EPSCs and amplitude of evoked EPSCs. The effects were mimicked by sulprostone, an agonist to PGE 2 EP 3 receptors. In contrast, PGE 2 had no distinct effect on IPSCs. In addition, spontaneous action potential of the dl-PAG neurons was recorded using whole cell current-clamp methods. PGE 2 significantly attenuated the discharge rate of the dl-PAG neurons. The decreased firing activity was abolished in the presence of glutamate NMDA and non-NMDA receptors antagonists. The results from the current study provide the first evidence indicating that PGE 2 inhibits the neuronal activity of the dl-PAG via selective attenuation of glutamatergic synaptic inputs, likely due to activation of presynaptic EP 3 receptors.

show abstract

“…Its autonomic effects have been well studied in animals [92,[114][115][116][117] and changes noted with DBS [101]. We have demonstrated a positive correlation between the degree of analgesia in patients receiving PAG DBS and the magnitude of blood pressure reduction [118], and have shown that whereas dorsal PAG stimulation can acutely elevate blood pressure, ventral stimulation reduces it [119,120].…”

Section: Physiologymentioning

confidence: 69%

“…A wealth of electrophysiological, anatomical, and radiological evidence in humans and animals, reviewed elsewhere, establishes both PAG and VP as structures important to pain perception and the pathophysiology of chronic pain syndromes [86][87][88][89][90][91][92][93][94]. The subtleties of hierarchical position and the behavioral function of individual brain structures, whether sensory-discriminative, attentional, motivational-affective, or hedonic, are much debated.…”

Section: Physiologymentioning

confidence: 99%

Neuropathic Pain and Deep Brain Stimulation

Pereira

Aziz

2014

Neurotherapeutics

View full text Add to dashboard Cite

Deep brain stimulation (DBS) is a neurosurgical intervention the efficacy, safety, and utility of which are established in the treatment of Parkinson's disease. For the treatment of chronic, neuropathic pain refractory to medical therapies, many prospective case series have been reported, but few have published findings from patients treated with current standards of neuroimaging and stimulator technology over the last decade . We summarize the history, science, selection, assessment, surgery, programming, and personal clinical experience of DBS of the ventral posterior thalamus, periventricular/periaqueductal gray matter, and latterly rostral anterior cingulate cortex (Cg24) in 113 patients treated at 2 centers (John Radcliffe, Oxford, UK, and Hospital de São João, Porto, Portugal) over 13 years. Several experienced centers continue DBS for chronic pain, with success in selected patients, in particular those with pain after amputation, brachial plexus injury, stroke, and cephalalgias including anesthesia dolorosa. Other successes include pain after multiple sclerosis and spine injury. Somatotopic coverage during awake surgery is important in our technique, with cingulate DBS under general anesthesia considered for whole or hemibody pain, or after unsuccessful DBS of other targets. Findings discussed from neuroimaging modalities, invasive neurophysiological insights from local field potential recording, and autonomic assessments may translate into improved patient selection and enhanced efficacy, encouraging larger clinical trials.

show abstract

Functional characteristics of the midbrain periaqueductal gray

Cited by 785 publications

References 251 publications

μ Opiate Receptor Gene Dose Effects on Different Morphine Actions Evidence for Differential in vivo μ Receptor Reserve

μ Opiate Receptor Gene Dose Effects on Different Morphine Actions Evidence for Differential in vivo μ Receptor Reserve

Prostaglandin E2 (PGE2) inhibits glutamatergic synaptic transmission in dorsolateral periaqueductal gray (dl-PAG)

Neuropathic Pain and Deep Brain Stimulation

Contact Info

Product

Resources

About