Functional cardiac Na+ channels are expressed in human melanoma cells

Xie, An; Gallant, Benjamin; Guo, Han; González, Alfredo; Clark, Matthew; Madigan, Audrey; Feng, Feng; Chen, Hong Duo; Cui, Yali; Dudley, Samuel C.; Wan, Yinsheng

doi:10.3892/ol.2018.8865

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…Furthermore, the authors suggest that UVA radiation modification of NaV1.5 provides valuable clues for ischemia/reperfusion injury in the heart and the central nervous system. In addition, NaV1.5 has been found to be expressed in human melanoma cells and has been associated with cancer invasiveness and metastasis [ 56 , 57 ].…”

Section: Various Biomarkers Tied To Uva Exposure and To Melanomamentioning

confidence: 99%

A Proposed New Model to Explain the Role of Low Dose Non-DNA Targeted Radiation Exposure in Chronic Fatigue and Immune Dysfunction Syndrome

Cocchetto

Seymour

Mothersill

2023

IJMS

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Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS) is considered to be a multidimensional illness whose etiology is unknown. However, reports from Chernobyl, as well as those from the United States, have revealed an association between radiation exposure and the development of CFIDS. As such, we present an expanded model using a systems biology approach to explain the etiology of CFIDS as it relates to this cohort of patients. This paper proposes an integrated model with ionizing radiation as a suggested trigger for CFIDS mediated through UVA induction and biophoton generation inside the body resulting from radiation-induced bystander effects (RIBE). Evidence in support of this approach has been organized into a systems view linking CFIDS illness markers with the initiating events, in this case, low-dose radiation exposure. This results in the formation of reactive oxygen species (ROS) as well as important immunologic and other downstream effects. Furthermore, the model implicates melanoma and subsequent hematopoietic dysregulation in this underlying process. Through the identification of this association with melanoma, clinical medicine, including dermatology, hematology, and oncology, can now begin to apply its expansive knowledge base to provide new treatment options for an illness that has had few effective treatments.

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Section: Various Biomarkers Tied To Uva Exposure and To Melanomamentioning

confidence: 99%

A Proposed New Model to Explain the Role of Low Dose Non-DNA Targeted Radiation Exposure in Chronic Fatigue and Immune Dysfunction Syndrome

Cocchetto

Seymour

Mothersill

2023

IJMS

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Membrane Transporters and Channels in Melanoma

Böhme

Schönherr

Eberle

et al. 2020

Reviews of Physiology, Biochemistry and Pharmacology

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In Vivo Evidence for Voltage-Gated Sodium Channel Expression in Carcinomas and Potentiation of Metastasis

Djamgoz

Fraser

Brackenbury

2019

Cancers

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A wide body of evidence suggests that voltage-gated sodium channels (VGSCs) are expressed de novo in several human carcinomas where channel activity promotes a variety of cellular behaviours integral to the metastatic cascade. These include directional motility (including galvanotaxis), pH balance, extracellular proteolysis, and invasion. Contrary to the substantial in vitro data, however, evidence for VGSC involvement in the cancer process in vivo is limited. Here, we critically assess, for the first time, the available in vivo evidence, hierarchically from mRNA level to emerging clinical aspects, including protein-level studies, electrolyte content, animal tests, and clinical imaging. The evidence strongly suggests that different VGSC subtypes (mainly Nav1.5 and Nav1.7) are expressed de novo in human carcinoma tissues and generally parallel the situation in vitro. Consistent with this, tissue electrolyte (sodium) levels, quantified by clinical imaging, are significantly higher in cancer vs. matched non-cancer tissues. These are early events in the acquisition of metastatic potential by the cancer cells. Taken together, the multi-faceted evidence suggests that the VGSC expression has clinical (diagnostic and therapeutic) potential as a prognostic marker, as well as an anti-metastatic target. The distinct advantages offered by the VGSC include especially (1) its embryonic nature, demonstrated most clearly for the predominant neonatal Nav1.5 expression in breast and colon cancer, and (2) the specifically druggable persistent current that VGSCs develop under hypoxic conditions, as in growing tumours, which promotes invasiveness and metastasis.

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Functional cardiac Na+ channels are expressed in human melanoma cells

Cited by 3 publications

References 23 publications

A Proposed New Model to Explain the Role of Low Dose Non-DNA Targeted Radiation Exposure in Chronic Fatigue and Immune Dysfunction Syndrome

A Proposed New Model to Explain the Role of Low Dose Non-DNA Targeted Radiation Exposure in Chronic Fatigue and Immune Dysfunction Syndrome

Membrane Transporters and Channels in Melanoma

In Vivo Evidence for Voltage-Gated Sodium Channel Expression in Carcinomas and Potentiation of Metastasis

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