Functional brain networks in the schizophrenia spectrum and bipolar disorder with psychosis

Dellen, Edwin van; Börner, Corinna; Schutte, Maya; Montfort, Simone van; Boks, Marco P.; Cahn, Wiepke; Haren, Neeltje E.M. van; Mandl, René C.W.; Stam, Cornelis J.; Sommer, Iris

doi:10.1038/s41537-020-00111-6

Cited by 21 publications

(27 citation statements)

References 62 publications

(120 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The connection intensity of SCH patients was lower than that among BD patients and HCs, but there was no difference in network topology between groups. In contrast, BD patients in another study had a less complete network topology, while the connection intensity was not disturbed (78). Recent studies have found that the connectivity of the whole brain network was increased in SCH patients but not in BD patients.…”

Section: Discussionmentioning

confidence: 79%

Electroencephalographic Microstates in Schizophrenia and Bipolar Disorder

2021

View full text Add to dashboard Cite

Schizophrenia (SCH) and bipolar disorder (BD) are characterized by many types of symptoms, damaged cognitive function, and abnormal brain connections. The microstates are considered to be the cornerstones of the mental states shown in EEG data. In our study, we investigated the use of microstates as biomarkers to distinguish patients with bipolar disorder from those with schizophrenia by analyzing EEG data measured in an eyes-closed resting state. The purpose of this article is to provide an electron directional physiological explanation for the observed brain dysfunction of schizophrenia and bipolar disorder patients.Methods: We used microstate resting EEG data to explore group differences in the duration, coverage, occurrence, and transition probability of 4 microstate maps among 20 SCH patients, 26 BD patients, and 35 healthy controls (HCs).Results: Microstate analysis revealed 4 microstates (A–D) in global clustering across SCH patients, BD patients, and HCs. The samples were chosen to be matched. We found the greater presence of microstate B in BD patients, and the less presence of microstate class A and B, the greater presence of microstate class C, and less presence of D in SCH patients. Besides, a greater frequent switching between microstates A and B and between microstates B and A in BD patients than in SCH patients and HCs and less frequent switching between microstates C and D and between microstates D and C in BD patients compared with SCH patients.Conclusion: We found abnormal features of microstate A, B in BD patients and abnormal features of microstate A, B, C, and D in SCH patients. These features may indicate the potential abnormalities of SCH patients and BD patients in distributing neural resources and influencing opportune transitions between different states of activity.

show abstract

Section: Discussionmentioning

confidence: 79%

Electroencephalographic Microstates in Schizophrenia and Bipolar Disorder

2021

View full text Add to dashboard Cite

show abstract

“…The results of our ROC analyses suggest that the right hippocampal volume is a potential marker for differentiation between SZ and BD. To this end, multimodal functional neuroimaging studies [26,[51][52][53][54][55][56][57][58][59][60][61] that combine structural MRI [3,16,[18][19][20][21]23,[26][27][28][42][43][44]51,[61][62][63], functional MRI [26,[53][54][55][56][57][58][59][60][61]64,65], magnetic resonance spectroscopy [66][67][68][69], positron emission tomography [69][70][71][72], elec...…”

Section: Discussionmentioning

confidence: 99%

“…The results of our ROC analyses suggest that the right hippocampal volume is a potential marker for differentiation between SZ and BD. To this end, multimodal functional neuroimaging studies [ 26 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ] that combine structural MRI [ 3 , 16 , 18 , 19 , 20 , 21 , 23 , 26 , 27 , 28 , 42 , 43 , 44 , 51 , 61 , 62 , 63 ], functional MRI [ 26 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 64 , 65 ], magnetic resonance spectroscopy [ 66 , 67 , 68 , 69 ], positron emission tomography [ 69 , 70 , 71 , 72 ], electroencephalography, and magnetoencephalography [ 4 , 5 , 6 , 7 , 8 , 9 , 59 , ...…”

Section: Discussionmentioning

confidence: 99%

Lower Hippocampal Volume in Patients with Schizophrenia and Bipolar Disorder: A Quantitative MRI Study

Sato

Hirano

Hirakawa

et al. 2021

JPM

View full text Add to dashboard Cite

Since patients with schizophrenia (SZ) and bipolar disorder (BD) share many biological features, detecting biomarkers that differentiate SZ and BD patients is crucial for optimized treatments. High-resolution magnetic resonance imaging (MRI) is suitable for detecting subtle brain structural differences in patients with psychiatric disorders. In the present study, we adopted a neuroanatomically defined and manually delineated region of interest (ROI) method to evaluate the amygdalae, hippocampi, Heschl’s gyrus (HG), and planum temporale (PT), because these regions are crucial in the development of SZ and BD. ROI volumes were measured using high resolution MRI in 31 healthy subjects (HS), 23 SZ patients, and 21 BD patients. Right hippocampal volumes differed significantly among groups (HS > BD > SZ), whereas left hippocampal volumes were lower in SZ patients than in HS and BD patients (HS = BD > SZ). Volumes of the amygdalae, HG, and PT did not differ among the three groups. For clinical correlations, there were no significant associations between ROI volumes and demographics/clinical symptoms. Our study revealed significant lower hippocampal volume in patients with SZ and BD, and we suggest that the right hippocampal volume is a potential biomarker for differentiation between SZ and BD.

show abstract

“…Several studies have found evidence of that lowered connectivity at baseline is either normalised or partly normalised after antipsychotic treatment 11,18 (although see also 50,51 ).…”

Section: Connectivity Changes In Antipsychotic-treated Patientsmentioning

confidence: 99%

Longitudinal Changes in Functional Connectivity in Antipsychotic-treated and Antipsychotic-naive Patients with First Episode Psychosis

Chopra

Francey

O’Donoghue

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Altered functional connectivity (FC) is a common finding in resting-state functional Magnetic Resonance Imaging (rs-fMRI) studies of people with psychosis, yet how FC disturbances evolve in the early stages of illness, and how antipsychotics may influence the temporal evolution of these disturbances, remains unclear. Here, we scanned first episode psychosis (FEP) patients who were and were not exposed to antipsychotic medication during the first six months of illness at baseline, three months, and 12 months, to characterize how FC changes over time and in relation to medication use. Methods: Sixty-two antipsychotic-naive patients with FEP received either an atypical antipsychotic or a placebo pill over a treatment period of 6 months. Both FEP groups received intensive psychosocial therapy. A healthy control group (n=27) was also recruited. A total of 202 rs-fMRI scans were obtained across three timepoints: baseline, 3-months and 12-months. Our primary aim was to differentiate patterns of FC in antipsychotic-treated and antipsychotic-naive patients within the first 3 months of treatment, and to examine associations with clinical and functional outcomes. A secondary aim was to investigate long-term effects at the 12-month timepoint. Results: At baseline, FEP patients showed widespread functional dysconnectivity in comparison to controls, with reductions predominantly affecting interactions between the default mode network (DMN), limbic systems, and the rest of the brain. From baseline to 3 months, patients receiving placebo showed increased FC principally within the same systems, and some of these changes correlated with improved clinical outcomes. Antipsychotic exposure was associated with increased FC primarily between the thalamus and the rest of the brain. At the 12-month follow-up, antipsychotic treatment was associated with a prolonged increase of FC primarily in the DMN and limbic systems. Conclusions and Relevance: Antipsychotic-naive FEP patients show widespread functional dysconnectivity at baseline, followed by an early normalization of DMN and paralimbic dysfunction in patients receiving a psychosocial intervention only. Antipsychotic exposure is associated with distinct FC changes, principally concentrated on thalamo-cortical and limbic networks.

show abstract

Functional brain networks in the schizophrenia spectrum and bipolar disorder with psychosis

Cited by 21 publications

References 62 publications

Electroencephalographic Microstates in Schizophrenia and Bipolar Disorder

Electroencephalographic Microstates in Schizophrenia and Bipolar Disorder

Lower Hippocampal Volume in Patients with Schizophrenia and Bipolar Disorder: A Quantitative MRI Study

Longitudinal Changes in Functional Connectivity in Antipsychotic-treated and Antipsychotic-naive Patients with First Episode Psychosis

Contact Info

Product

Resources

About