Functional brain imaging of olfactory processing in monkeys

Boyett-Anderson, Jesse M.; Lyons, David M.; Reiss, Allan L.; Schatzberg, Alan F.; Menon, Vinod

doi:10.1016/s1053-8119(03)00288-x

Cited by 23 publications

(18 citation statements)

References 55 publications

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“…Although olfactory fMRI activations had been reported outside the OB in NHPs (Boyett-Anderson et al, 2003) and humans (Sobel et al, 2000;Yang et al, 1997), no such fMRI activations were observed in our study. To be certain that the lack of the activations in higher olfactory regions is not caused by the possible small signal changes (i.e., low contrast to noise ratio), the activation maps of the NHP No.…”

Section: Olfactory Fmri Activations In Anesthetized Nhpscontrasting

confidence: 94%

“…Using traditional blood oxygenation level dependent (BOLD) methods, fMRI activations due to odor stimulation have been reported in the olfactory bulb (OB) of rodents (Martin et al, 2007;Poplawsky and Kim, 2014;Schafer et al, 2005;Xu et al, 2000;Xu et al, 2005). However, in humans and non-human primates (NHP), no fMRI activations have been reported in the OB (Boyett-Anderson et al, 2003;Gottfried et al, 2002;Poellinger et al, 2001;Sobel et al, 1998;Sobel et al, 2000;Yang et al, 1997). The reason for this difference between rodents and humans is not clear.…”

Section: Introductionmentioning

confidence: 99%

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Functional imaging of olfaction by CBV fMRI in monkeys: Insight into the role of olfactory bulb in habituation

et al. 2015

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Section: Olfactory Fmri Activations In Anesthetized Nhpscontrasting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Functional imaging of olfaction by CBV fMRI in monkeys: Insight into the role of olfactory bulb in habituation

et al. 2015

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“…2A). Furthermore, in agreement with fMRI studies in humans and monkeys (Boyett-Anderson et al, 2003;Sobel et al, 1998), we found that odors stimulated the mouse cerebellum.…”

Section: Imaging Sensory-evoked Activity In the Mouse Hippocampussupporting

confidence: 91%

CA3 NMDA receptors are required for experience‐dependent shifts in hippocampal activity

et al. 2007

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The anatomical distribution of sensory-evoked activity recorded from the hippocampal long-axis can shift depending on prior experience. In accordance with Marr's computational model of hippocampal function, CA3 NMDA receptors have been hypothesized to mediate this experience-dependent shift in hippocampal activity. Here we tested this hypothesis by investigating genetically-modified mice in which CA3 NMDA receptors are selectively knocked-out (CA3-NR1 KO). First, we were required to develop an fMRI protocol that can record sensory-evoked activity from the mouse hippocampal long-axis. This goal was achieved in part by using a dedicated mouse scanner to image odor-evoked activity, and by using non-EPI (echo planer imaging) pulse sequences. As in humans, odors were found to evoke a ventral-predominant activation pattern in the mouse hippocampus. More importantly, odor-evoked activity shifted in an experience-dependent manner. Finally, we found that the experience-dependent shift in hippocampal long-axis activity is blocked in CA3-NR1 knock-out mice. These findings establish a cellular mechanism for the plasticity imaged in the hippocampal long-axis, suggesting how experience-dependent modifications of hippocampal activity can contribute to its mnemonic function.

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“…In the present protocol, we used two odours as CS. The vermis cerebellum has been found consistently activated during odour perception tasks [41][42][43][44]. It is known that an extended prefrontallimbic network sustains olfactory processing and memory [45] Moreover, cocaine may act locally in the cerebellum and trigger in situ aberrant plasticity [27].…”

Section: Discussionmentioning

confidence: 99%

Cerebellar hallmarks of conditioned preference for cocaine

Carbó-Gas

Vázquez-Sanromán

Gil‐Miravet

et al. 2014

Physiology & Behavior

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Pavlovian conditioning tunes the motivational drive of drug-associated stimuli, fostering the probability of those environmental stimuli to promote and trigger drug seeking and taking.Interestingly, different areas in the cerebellum are involved in the formation and longlasting storage of Pavlovian emotional memory. Very recently, we have shown that conditioned preference for an odour associated with cocaine was directly correlated with cFOS expression in cells at the dorsal region of the granule cell layer of the cerebellar vermis. The main goal of the current investigation was to further extend the description of cFOS-IR patterns in cerebellar circuitry after training mice in a cocaine-odour Pavlovian conditioning procedure, including now the major inputs (the inferior olive and pontine nuclei) and one of the output nuclei (the medial deep nucleus) of the cerebellum. The results showed that the cerebellar hallmark of preference towards an odour cue associated to cocaine is an increase in cFOS expression in the dorsal part of the granule cell layer. cFOS-IR levels expressed in the granule cell layer of mice that did not show cocaine conditioned preference did not differ from the basal levels. Remarkably, mice subjected to a random cocaine-odour pairing procedure (the unpaired group) exhibited higher cFOS-IR in the inferior olive, the pontine nuclei and in the deep medial nucleus. Therefore, our findings suggest that inputs and the output of cerebellar circuitry are enhanced when contingency between the CS+ and cocaine is lacking.

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Functional brain imaging of olfactory processing in monkeys

Cited by 23 publications

References 55 publications

Functional imaging of olfaction by CBV fMRI in monkeys: Insight into the role of olfactory bulb in habituation

Functional imaging of olfaction by CBV fMRI in monkeys: Insight into the role of olfactory bulb in habituation

CA3 NMDA receptors are required for experience‐dependent shifts in hippocampal activity

Cerebellar hallmarks of conditioned preference for cocaine

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