Functional biotransformation of phytoestrogens by gut microbiota with impact on cancer treatment

Farhat, Esma Karahmet; Sher, Emina Karahmet; Džidić-Krivić, Amina; Banjari, Ines; Sher, Farooq

doi:10.1016/j.jnutbio.2023.109368

Cited by 22 publications

(9 citation statements)

References 111 publications

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“…It is widely accepted that gut microbes play a vital part in maintaining intestinal balance [49] and are closely related to human health or disease pathogenesis [50]. It had been reported that IBD was frequently linked with a reduction of bacterial diversity, an alteration of the gut microbiota, a drop in Firmicutes [51], and a rise in Proteobacteria [52].…”

Section: Discussionmentioning

confidence: 99%

Effect of Extracelluar Vesicles Derived from Akkermansia muciniphila on Intestinal Barrier in Colitis Mice

Zheng,

Hao,

Liu

et al. 2023

Nutrients

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Inflammatory bowel disease (IBD) is a chronic and recurrent disease. It has been observed that the incidence and prevalence of IBD are increasing, which consequently raises the risk of developing colon cancer. Recently, the regulation of the intestinal barrier by probiotics has become an effective treatment for colitis. Akkermansia muciniphila-derived extracellular vesicles (Akk EVs) are nano-vesicles that contain multiple bioactive macromolecules with the potential to modulate the intestinal barrier. In this study, we used ultrafiltration in conjunction with high-speed centrifugation to extract Akk EVs. A lipopolysaccharide (LPS)-induced RAW264.7 cell model was established to assess the anti-inflammatory effects of Akk EVs. It was found that Akk EVs were able to be absorbed by RAW264.7 cells and significantly reduce the expression of nitric oxide (NO), TNF-α, and IL-1β (p < 0.05). We explored the preventative effects on colitis and the regulating effects on the intestinal barrier using a mouse colitis model caused by dextran sulfate sodium (DSS). The findings demonstrated that Akk EVs effectively prevented colitis symptoms and reduced colonic tissue injury. Additionally, Akk EVs significantly enhanced the effectiveness of the intestinal barrier by elevating the expression of MUC2 (0.53 ± 0.07), improving mucus integrity, and reducing intestinal permeability (p < 0.05). Moreover, Akk EVs increased the proportion of the beneficial bacteria Firmicutes (33.01 ± 0.09%) and downregulated the proportion of the harmful bacteria Proteobacteria (0.32 ± 0.27%). These findings suggest that Akk EVs possess the ability to regulate immune responses, protect intestinal barriers, and modulate the gut microbiota. The research presents a potential intervention approach for Akk EVs to prevent colitis.

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Section: Discussionmentioning

confidence: 99%

Effect of Extracelluar Vesicles Derived from Akkermansia muciniphila on Intestinal Barrier in Colitis Mice

Zheng,

Hao,

Liu

et al. 2023

Nutrients

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“… 40 DPN involves autonomic neuropathy to a certain extent and a review 41 summarized that autonomic nerve dysfunction was correlated with gut microbiome, involving byproducts of bacterial fermentation including butyrate, which has been proved with huge benefits to body. 42 Formate was first found decreased in DPN involving the significant role of intestinal flora, contributing to the research of more function of formate. Creatine can be metabolized to methylamine by the gut microbiome ( Figure 5 ), which is a potential exogenous source of formate.…”

Section: Discussionmentioning

confidence: 99%

Formate Might Be a Novel Potential Serum Metabolic Biomarker for Type 2 Diabetic Peripheral Neuropathy

Xu,

Xue,

Zhou

et al. 2023

DMSO

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Background As one of the most frequent complications of type 2 diabetes mellitus (T2DM), diabetic peripheral neuropathy (DPN) shows a profound impact on 50% of patients with symptoms of neuropathic pain, numbness and other paresthesia. No valid serum biomarkers for the prediction of DPN have been identified in the clinic so far. This study is to investigate the potential serum biomarkers for DPN firstly based on 1 H-Nuclear Magnetic Resonance ( 1 H-NMR)-based metabolomics technique. Methods Thirty-six patients enrolled in this study were divided into two groups: 18 T2DM patients without DPN (T2DM group) and 18 T2DM patients with DPN (DPN group). Serum metabolites were measured via 1 H-NMR spectroscopy. Bioinformatic approaches including principal component analysis (PCA), orthogonal partial least squares-discriminant analysis (OPLS-DA), independent sample t -test, Fisher’s test, Pearson and Spearman correlation analysis, Stepwise multiple linear regression analysis and receiver operating characteristic (ROC) curve analysis were used to identify the potential altered serum biomarkers. Results A total of 20 metabolites were obtained and further analyzed. Formate was identified as the only potential biomarker that decreased in the DPN group with statistical significance after multiple comparisons (p<0.05). Formate also displayed a negative relationship with some elevated clinical markers in DPN. ROC curve analysis showed a good discriminative ability for formate in DPN with an area under the curve (AUC) value of 0.981. Conclusion Formate could be considered a potential serum metabolic biomarker for DPN. The reduced level of formate in DPN may be associated with mitochondrial dysfunction and gut microbiota alteration. Monitoring the level of serum formate would be an important strategy for the early diagnosis of DPN and a supplement of formate may be a promising treatment for DPN in the future.

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“…However, these benefits are observed primarily in women who possess the ability to convert lignans into the active form of END and ENL. 108 4.2. Lignans and Menopausal Symptoms.…”

Section: Lignans and Breast Cancermentioning

confidence: 99%

“… Recent studies have provided new insights into phytoestrogens having a protective effect in the development of hormone-dependent breast cancer among menopausal women. However, these benefits are observed primarily in women who possess the ability to convert lignans into the active form of END and ENL …”

Section: Health Benefits Of Lignansmentioning

confidence: 99%

The What and Who of Dietary Lignans in Human Health: Special Attention to Estrogen Effects and Safety Evaluation

Li,

Ma,

Luo

et al. 2023

J. Agric. Food Chem.

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Lignans are a group of phenolic compounds found in plant-based diets. The human body can obtain lignans through diet, which are then metabolized into enterolignans. The enterolignans have been linked to several health benefits, including anticancer, anti-inflammatory, antioxidant effects, and estrogen effects. This review explores the relationship between the estrogenic effects of lignans and health. This review not only considers the estrogen-like activity of lignans but also discusses the safe dosage of lignans at different life stages. In addition, this review also identified other types of bioactive compounds that can act synergistically with lignans to promote health. Studies have shown that lignan administration during pregnancy and lactation reduces the risk of breast cancer in offspring. Further studies are needed to investigate the estrogenic safety effects of lignan on pregnant women and children. Whether lignans combine with other nutrients in complex food substrates to produce synergistic effects remains to be investigated. This review provides a basis for future studies on the safe dose of lignan and recommended dietary intake of lignan. We believe that the acquired as discussed here has implications for developing dietary therapies that can promote host nutrition and modulate estrogenic diseases.

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Functional biotransformation of phytoestrogens by gut microbiota with impact on cancer treatment

Cited by 22 publications

References 111 publications

Effect of Extracelluar Vesicles Derived from Akkermansia muciniphila on Intestinal Barrier in Colitis Mice

Effect of Extracelluar Vesicles Derived from Akkermansia muciniphila on Intestinal Barrier in Colitis Mice

Formate Might Be a Novel Potential Serum Metabolic Biomarker for Type 2 Diabetic Peripheral Neuropathy

The What and Who of Dietary Lignans in Human Health: Special Attention to Estrogen Effects and Safety Evaluation

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