Functional Biomaterials: Drug Delivery and Biomedical Applications Polymeric Micelle in Drug Delivery Applications

Khatun, Sajmina; Bonala, Sabeerabi; Pogu, Sunil Venkanna; Rengan, Aravind Kumar

doi:10.1007/978-981-16-7152-4_1

Cited by 2 publications

(2 citation statements)

References 164 publications

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“…Currently, the permanent and growing interest in the study and advanced development of biomaterials is focused on medical or healthcare applications due to the requirements in the domain of drug administration, tissue engineering, medical device industry, permanent or temporary implants. As the need for high-accuracy and individualized treatments continues to grow, research pursues both the improvement of biomaterials in classic applications and the obtaining of new effective bioactive materials for multiple advanced applications, regenerative medicine or other health dysfunctions, including theranostic biomaterials (diagnosis, monitoring capabilities and combined therapy) [1][2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Chelu,

Musuc

2023

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Biomaterials are mostly any natural and synthetic materials which are compatible from a biological point of view with the human body. Biomaterials are widely used to sustain, increase, reestablish or substitute the biological function of any injured tissue and organ from the human body. Additionally, biomaterials are uninterruptedly in contact with the human body, i.e., tissue, blood and biological fluids. For this reason, an essential feature of biomaterials is their biocompatibility. Consequently, this review summarizes the classification of different types of biomaterials based on their origin, as natural and synthetic ones. Moreover, the advanced applications in pharmaceutical and medical domains are highlighted based on the specific mechanical and physical properties of biomaterials, concerning their use. The high-priority challenges in the field of biomaterials are also discussed, especially those regarding the transfer and implementation of valuable scientific results in medical practice.

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Section: Introductionmentioning

confidence: 99%

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Chelu,

Musuc

2023

Processes

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“…Moreover, normal micelles are more prone to encapsulate hydrophobic drugs [ 19 ]. Despite their limitations, many examples are reported in the literature describing the use of normal micelles as nanocarriers for the transport of drugs, nucleic acids, proteins, and contrast agents [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Stabilized Reversed Polymeric Micelles as Nanovector for Hydrophilic Compounds

et al. 2023

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Small hydrophilic drugs are widely used for systemic administration, but they suffer from poor absorption and fast clearance. Their nanoencapsulation can improve biodistribution, targeted delivery, and pharmaceutical efficacy. Hydrophilics are effectively encapsulated in compartmented particles, such as liposomes or extracellular vesicles, which are biocompatible but poorly customizable. Polymeric vectors can form compartmental structures, also being functionalizable. Here, we report a system composed of polymeric stabilized reversed micelles for hydrophilic drugs encapsulation. We optimized the preparation procedure, and calculated the critical micellar concentration. Then, we developed a strategy for stabilization that improves micelle stability upon dilution. We tested the drug loading and delivery capabilities with creatine as a drug molecule. Prepared stabilized reversed micelles had a size of around 130 nm and a negative z-potential around −16 mV, making them functional as a drug carrier. The creatine cargo increased micelle size and depended on the loading conditions. The higher amount of loaded creatine was around 60 μg/mg of particles. Delivery tests indicated full release within three days in micelles with the lower cargo, while higher loadings can provide a sustained release for longer times. Obtained results are interesting and encouraging to test the same system with different drug cargoes.

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Functional Biomaterials: Drug Delivery and Biomedical Applications Polymeric Micelle in Drug Delivery Applications

Cited by 2 publications

References 164 publications

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Stabilized Reversed Polymeric Micelles as Nanovector for Hydrophilic Compounds

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