Functional bioactive compounds in ginger, turmeric, and garlic

Ajanaku, C. O.; Ademosun, Olabisi Theresa; Atohengbe, Prudence Osahenomanse; Ajayi, Samuel O.; Obafemi, Yemisi Dorcas; Owolabi, Olayinka Ayotunde; Akinduti, P. A.; Ajanaku, K. O.

doi:10.3389/fnut.2022.1012023

Cited by 22 publications

(13 citation statements)

References 87 publications

(84 reference statements)

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“…Ginger notably exhibited a significantly higher (p < 0.05) quantity of flavonoids compared to garlic. These findings align consistently with previous studies [ 22 , 25 , 27 ]. Methanolic extracts derived from ginger have shown a higher concentration of flavonoids in comparison to aqueous extracts obtained from garlic [ 22 ].…”

Section: Phenolic and Flavonoid Contents In Extractssupporting

confidence: 94%

“…Medicinally significant plants and spices are routinely utilized in healthcare and veterinary applications across Asia. The compounds present in ginger and garlic, such as gingerol, shogaol, and allicin, are known for their broad-spectrum antibacterial activity [ 25 ]. Additionally, the metal content in garlic and ginger, including zinc, copper, iron, and manganese, may also play a role in their antibacterial activity [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant, antibacterial and antiviral effect of the combination of ginger and garlic extracts

Rajendrasozhan

2024

Bioinformation

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Garlic and ginger are well known as safe alternatives to traditional therapies. Limited information exists regarding antioxidant, antibacterial and antiviral capabilities of the combination of ginger and garlic. Standard methodologies were employed to determine the phytochemical compositions. Antioxidant activities were evaluated through DPPH and FRAP assays. Notably, in DPPH assay, combination of ginger and garlic extracts displayed significantly higher (85.44%, p < 0.005) antioxidant activity even at lower concentrations (6 mg/ml) compared to ginger and garlic extracts alone. Similar findings were observed for FRAP assay. At low concentration of extracts (25 μg/ml), combination of ginger and garlic exhibited significant (p < 0.005) increase in reducing activity (51%) compared to ginger or garlic extracts alone. Significant antibacterial and antiviral activities were exhibited by the combination of both ginger and garlic extracts as compared to ginger and garlic extracts alone. The combined effect of garlic and ginger exhibited a synergistic effect in bacterial and viral growth inhibition. These findings suggest that the diverse phytochemical compositions of the ginger and garlic varieties contribute to their strong antioxidant properties, potentially positioning them as valuable therapeutics for bacterial and viral infections. Further analysis will be required for their widespread utilization and pharmaceutical applications.

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Section: Phenolic and Flavonoid Contents In Extractssupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Antioxidant, antibacterial and antiviral effect of the combination of ginger and garlic extracts

Rajendrasozhan

2024

Bioinformation

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“…15,16 Their work also revealed low LDL concentrations in regions of low shear stress. 13,17 Plaque stenosis has been reported to present higher anterograde motion in patients with stenosed carotid arteries. This anterograde motion was found to be directly proportional to plaque severity, and blood flow patterns in stenosed carotid arteries notably gave better estimates of motion compared to nonstenosed arteries.…”

Section: Discussionmentioning

confidence: 99%

Computational simulation of the effects of blood flow velocity on atherosclerosis progression in a human carotid artery

Alagbe,

Amoo,

Oriaifo

et al. 2024

F1000Res

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Background Atherosclerosis is a build-up of low-density lipoproteins (LDL) in the channels of blood vessels. This occludes the vessels and, occurring in the carotid arteries, portends conditions that favour stroke. This work is an attempt to mathematically represent the physiological process of atherosclerosis caused by plaques on the walls of the human arteries. Aim Provide insight into the effect of blood flow velocity on wall shear stress and its implications on atherosclerosis progression in a human carotid artery via computational simulation. Methods The effect of blood velocity on plaque growth and progression is simulated using COMSOL multi-physics. The human carotid was modeled in 2-D with Stokes law for model flow. The simulation began with a plaque-free vessel with velocities of 30 m/s – 125 m/s. Results Results showed that the rate of plaque initiation dropped as the blood velocity increased from 30 m/s to 125 m/s; higher inlet velocities gave lower plaque growth; the highest degree of 30% stenosis was recorded at a blood velocity of 30 m/s. Plaque height significantly affects the Plaque wall Stress, PWS, and its distribution around the plaque and arterial wall; higher plaque heights experience higher velocity distribution around the plaque, causing a higher force associated with blood flow around the plaque, resulting in higher compression stress. More compressional stresses are localized around the root, which would encourage growth as well as possible rupture at higher velocities. These ruptured plaques potentially narrow or block the arteries and prevent blood flow. This is atherosclerosis and can lead to a heart attack. Conclusion Results from this study can find significant use in the understanding, management, and treatment of atherosclerosis since the regulation of blood velocity and pressure plays a major role in the progress of atherosclerosis in the carotid artery which raises the risk of stroke.

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“…Garlic ( Allium sativum ) contains many bioactive compounds ( Poojary et al, 2017 ), and organic sulfide compounds ( Ajanaku et al, 2022 ). Garlic is rich in saponin, tannin, alkaloid, and flavonoids as phytochemicals.…”

Section: Background Informationmentioning

confidence: 99%

Role of oral phytogenic supplementation to protect cardiac, hepatic, nephrotic, and splenic oxidative stress in broiler chickens

Abubakar,

Uchechi,

Olayinka Abosede

et al. 2023

Translational Animal Science

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This study investigated the effects of adding essential oils of garlic, ginger, turmeric and cinnamon to drinking water on cardiac, hepatic, nephrotic, splenic oxidative status of broiler chickens. A batch of 200 one-day old Arbo acre broiler chicks was administered with Control (Water: no additive), 30ml/L of cinnamon, ginger, turmeric or garlic essential oils in drinking water for 42 days. At day 43, 3 broiler chickens/replicates were sampled randomly, sacrificed and eviscerated. The hearts, spleens, kidneys and livers were excised and assayed for glutathione peroxidase, total antioxidant activity, catalase, superoxide dismutase and lipid peroxidation using standard protocols. In spleen broiler chickens, all additive essential oils increased (p<0.05) total antioxidant activity. Catalase, superoxide dismutase and glutathione peroxidase significantly increased (p<0.05) in garlic, ginger and turmeric essential oils except cinnamon. In kidney broiler chickens, lipid peroxidation was significantly reduced (p<0.05) in all the additive essential oils. Garlic, cinnamon and ginger essential oils increased (p<0.05) catalase, superoxide dismutase and glutathione peroxidase in kidney broiler chickens. In liver broiler chickens, lipid peroxidation and glutathione peroxidase were higher (p<0.05) in cinnamon essential oil than other additive essential oils. Superoxide dismutase and catalase were higher (p<0.05) in turmeric essential oils. In heart broiler chickens, all the additive essential oils significantly decreased (p<0.05) lipid peroxidation and increased (p<0.05) total antioxidant activity. In conclusion, oral garlic, turmeric and ginger essential oils supplementation did not reduce lipid peroxidation in spleen whereas cinnamon essential oil caused lipid peroxidation in liver of broiler chickens.

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Functional bioactive compounds in ginger, turmeric, and garlic

Cited by 22 publications

References 87 publications

Antioxidant, antibacterial and antiviral effect of the combination of ginger and garlic extracts

Antioxidant, antibacterial and antiviral effect of the combination of ginger and garlic extracts

Computational simulation of the effects of blood flow velocity on atherosclerosis progression in a human carotid artery

Role of oral phytogenic supplementation to protect cardiac, hepatic, nephrotic, and splenic oxidative stress in broiler chickens

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