Functional bioactive compounds in ginger, turmeric, and garlic

Ajanaku, C. O.; Ademosun, Olabisi Theresa; Atohengbe, Prudence Osahenomanse; Ajayi, Samuel O.; Obafemi, Yemisi Dorcas; Owolabi, Olayinka Ayotunde; Akinduti, P. A.; Ajanaku, K. O.

doi:10.3389/fnut.2022.1012023

Cited by 16 publications

(3 citation statements)

References 87 publications

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“…15,16 Their work also revealed low LDL concentrations in regions of low shear stress. 13,17 Plaque stenosis has been reported to present higher anterograde motion in patients with stenosed carotid arteries. This anterograde motion was found to be directly proportional to plaque severity, and blood flow patterns in stenosed carotid arteries notably gave better estimates of motion compared to nonstenosed arteries.…”

Section: Discussionmentioning

confidence: 99%

Computational simulation of the effects of blood flow velocity on atherosclerosis progression in a human carotid artery

Alagbe,

Amoo,

Oriaifo

et al. 2024

F1000Res

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Background Atherosclerosis is a build-up of low-density lipoproteins (LDL) in the channels of blood vessels. This occludes the vessels and, occurring in the carotid arteries, portends conditions that favour stroke. This work is an attempt to mathematically represent the physiological process of atherosclerosis caused by plaques on the walls of the human arteries. Aim Provide insight into the effect of blood flow velocity on wall shear stress and its implications on atherosclerosis progression in a human carotid artery via computational simulation. Methods The effect of blood velocity on plaque growth and progression is simulated using COMSOL multi-physics. The human carotid was modeled in 2-D with Stokes law for model flow. The simulation began with a plaque-free vessel with velocities of 30 m/s – 125 m/s. Results Results showed that the rate of plaque initiation dropped as the blood velocity increased from 30 m/s to 125 m/s; higher inlet velocities gave lower plaque growth; the highest degree of 30% stenosis was recorded at a blood velocity of 30 m/s. Plaque height significantly affects the Plaque wall Stress, PWS, and its distribution around the plaque and arterial wall; higher plaque heights experience higher velocity distribution around the plaque, causing a higher force associated with blood flow around the plaque, resulting in higher compression stress. More compressional stresses are localized around the root, which would encourage growth as well as possible rupture at higher velocities. These ruptured plaques potentially narrow or block the arteries and prevent blood flow. This is atherosclerosis and can lead to a heart attack. Conclusion Results from this study can find significant use in the understanding, management, and treatment of atherosclerosis since the regulation of blood velocity and pressure plays a major role in the progress of atherosclerosis in the carotid artery which raises the risk of stroke.

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Section: Discussionmentioning

confidence: 99%

Computational simulation of the effects of blood flow velocity on atherosclerosis progression in a human carotid artery

Alagbe,

Amoo,

Oriaifo

et al. 2024

F1000Res

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“…Garlic ( Allium sativum ) contains many bioactive compounds ( Poojary et al, 2017 ), and organic sulfide compounds ( Ajanaku et al, 2022 ). Garlic is rich in saponin, tannin, alkaloid, and flavonoids as phytochemicals.…”

Section: Background Informationmentioning

confidence: 99%

Role of oral phytogenic supplementation to protect cardiac, hepatic, nephrotic, and splenic oxidative stress in broiler chickens

Abubakar,

Uchechi,

Olayinka Abosede

et al. 2023

Translational Animal Science

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This study investigated the effects of adding essential oils of garlic, ginger, turmeric and cinnamon to drinking water on cardiac, hepatic, nephrotic, splenic oxidative status of broiler chickens. A batch of 200 one-day old Arbo acre broiler chicks was administered with Control (Water: no additive), 30ml/L of cinnamon, ginger, turmeric or garlic essential oils in drinking water for 42 days. At day 43, 3 broiler chickens/replicates were sampled randomly, sacrificed and eviscerated. The hearts, spleens, kidneys and livers were excised and assayed for glutathione peroxidase, total antioxidant activity, catalase, superoxide dismutase and lipid peroxidation using standard protocols. In spleen broiler chickens, all additive essential oils increased (p<0.05) total antioxidant activity. Catalase, superoxide dismutase and glutathione peroxidase significantly increased (p<0.05) in garlic, ginger and turmeric essential oils except cinnamon. In kidney broiler chickens, lipid peroxidation was significantly reduced (p<0.05) in all the additive essential oils. Garlic, cinnamon and ginger essential oils increased (p<0.05) catalase, superoxide dismutase and glutathione peroxidase in kidney broiler chickens. In liver broiler chickens, lipid peroxidation and glutathione peroxidase were higher (p<0.05) in cinnamon essential oil than other additive essential oils. Superoxide dismutase and catalase were higher (p<0.05) in turmeric essential oils. In heart broiler chickens, all the additive essential oils significantly decreased (p<0.05) lipid peroxidation and increased (p<0.05) total antioxidant activity. In conclusion, oral garlic, turmeric and ginger essential oils supplementation did not reduce lipid peroxidation in spleen whereas cinnamon essential oil caused lipid peroxidation in liver of broiler chickens.

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“…Turmeric powder, a yellow-brown spice which is the primary source of economic value for the plant, is produced via the pulverization of the plant’s rough, segmented rhizome [ 1 ]. In recent years, the demand for and consumption of turmeric and ginger have increased, and the US has become a top importer of these products from China and India [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Physical, Chemical, and Sensory Properties of a Turmeric-Fortified Pineapple Juice Beverage

Follett

Wall

Duff

et al. 2023

Foods

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Beverage mixtures based on pineapple (Ananas comosus) and turmeric (Curcuma longa) juice as a ready-to-drink product were developed, and their physicochemical, nutritional, and sensory properties were evaluated. Four different concentrations of turmeric juice (5%, 10%, 15%, and 20% (v/v)) were added to pineapple juice to make turmeric-fortified pineapple (TFP) juice samples. Pineapple juice without turmeric was the control. The L*, a*, b*, titratable acidity (TA), total antioxidant capacity, and %DPPH scavenging values, as well as the concentrations of the phenolic compounds curcumin and demethoxycurcumin, were significantly increased with increasing turmeric concentration. Thirty volatile compounds were detected in the mixed juice samples with turmeric. Most of the turmeric-specific compounds, including monoterpenes, sesquiterpenes and turmerones, were detected in the TFP juice samples. While the antioxidant activity of the juice samples increased with increasing turmeric concentration, the pineapple juice fortified with 10% turmeric (10%T) had the best overall quality as determined by panelists. Greater concentrations of turmeric were associated with decreased palatability due to reduced mouthfeel and sweetness and increased aftertaste and sourness. These results suggest that the 10%T juice could be developed into a commercial functional beverage with increased overall flavor and nutritional quality.

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Functional bioactive compounds in ginger, turmeric, and garlic

Cited by 16 publications

References 87 publications

Computational simulation of the effects of blood flow velocity on atherosclerosis progression in a human carotid artery

Computational simulation of the effects of blood flow velocity on atherosclerosis progression in a human carotid artery

Role of oral phytogenic supplementation to protect cardiac, hepatic, nephrotic, and splenic oxidative stress in broiler chickens

Physical, Chemical, and Sensory Properties of a Turmeric-Fortified Pineapple Juice Beverage

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