Functional associations of evolutionarily recent human genes exhibit sensitivity to the 3D genome landscape and disease
Katherine Fleck,
Victor Luria,
Nitanta Garag
et al.
Abstract:Genome organization is intricately tied to regulating genes and associated cell fate decisions. In this study, we examine the positioning and functional significance of human genes, grouped by their evolutionary age, within the 3D organization of the genome. We reveal that genes of different evolutionary origin have distinct positioning relationships with both domains and loop anchors, and remarkably consistent relationships with boundaries across cell types. While the functional associations of each group of … Show more
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