Functional Assessment of Canine Kidneys After Acute Vascular Occlusion on Gd-DTPA–Enhanced Dynamic Echo-Planar MR Imaging

Suga, Kazuyoshi; Ogasawara, Nagahisa; Okazaki, H; Sasai, Kazuhiko; Matsunaga, Naofumi

doi:10.1097/00004424-200111000-00006

Cited by 10 publications

(6 citation statements)

References 23 publications

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“…As a result, SI on T2/T2*WI of each layer of the left kidney in all groups markedly decreased, except TSE images of the IM layer. After arterial occlusion, SI on EPI of the left kidney significantly decreased, which was in agreement with a previous study (27). During reperfusion, SI in the cortex of the left kidney was almost restored to pre‐ligation levels similar to that of the right kidney.…”

Section: Discussionsupporting

confidence: 93%

“…Frank et al (33) defined three phases during the passage of the contrast agent through the kidney; specifically, vascular, tubular, and ductal phases, representing the outer cortex, outer medulla, and inner medulla, respectively. In this study, SI‐T curves of the control kidney also comprised three phases in each layer, consistent with previously reported data (27). We suggest that this may be a result of the higher temporal resolution employed in our investigation (frame/1.16 seconds).…”

Section: Discussionsupporting

confidence: 92%

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Functional evaluation of normothermic ischemia and reperfusion injury in dog kidney by combining MR diffusion‐weighted imaging and Gd‐DTPA enhanced first‐pass perfusion

Liu¹,

Xie²

2003

Magnetic Resonance Imaging

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Purpose:To evaluate functional alterations of renal ischemia and reperfusion injury using MR diffusion-weighted imaging and dynamic perfusion imaging. Materials and Methods:Twelve dogs were randomly divided into four groups. Animal renal ischemia was respectively induced for 30 (group 1), 60 (group 2), 90 (group 3), and 120 (group 4) minutes by left renal artery ligation under anesthesia. Using a 1.5 T MR system, true-FISP, TSE, EPI, and DWI sequences were acquired in five different periods; specifically, pre-ischemia, onset-ischemia, late ischemia, onset-reperfusion, and post-reperfusion. Moreover, a turbo-FLASH sequence (TR/TE/TI/FA ϭ 5.8/3.2/ 400 msec/10°) with a temporal resolution of 1.16 seconds was acquired. Signal intensity (SI) was measured in the cortex, outer medulla, and inner medulla of kidney. Apparent diffusion coefficient (ADC) values were calculated, and SI was plotted as a function of time. Results:In all animals, significant SI changes of the left kidney on T2/T2*WI were detected following ischemia-reperfusion insult compared to corresponding values of the right kidney. Following ligation, the ADC values decreased in all layers of the left kidney. Immediately after the release of ligation, ADC values in both outer and inner medulla of the left kidney remained lower than those of the right kidney in those animals which were induced with renal ischemia for 60, 90, and 120 minutes. In all groups, a uniphasic enhancement pattern was observed in the outer and inner medulla of the left kidney, accompanied by a decrease of the area under the curve. Conclusion:Our results suggest that MR diffusionweighted imaging and dynamic perfusion imaging are useful in identifying renal dysfunction following normothermic ischemia and reperfusion injury.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Functional evaluation of normothermic ischemia and reperfusion injury in dog kidney by combining MR diffusion‐weighted imaging and Gd‐DTPA enhanced first‐pass perfusion

Liu¹,

Xie²

2003

Magnetic Resonance Imaging

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“…40 Although the exact reason for the double echogenicity of the renal cortex in some patients is still unknown, considering the structure of the renal cortex, it is thought to be due to the difference in the degree of vascular distribution between the cortical cortex and the juxtamedullary cortex. 40,41 One textbook of pediatric US described that the renal cortex was subdivided into two zones and juxtamedullary cortex was hyperechoic to the rest of the cortex with acute rejection after kidney transplant. 42 Since there may be histological differences between humans and dogs, 40 it may be difficult to apply this finding equally, but it is a finding worth consideration.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic quantitative evaluation of acute and chronic renal disease using the renal cortical thickness to aorta ratio in dogs

Choo¹,

Kim²,

Kwon

et al. 2022

Vet Radiology Ultrasound

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The renal cortical thickness (RCT) has been correlated with renal function. Previous studies have also reported that the RCT:Abdominal aorta(Ao) ratio is constant in normal dogs with various physical factors. This multi‐center, retrospective, analytical study aimed to determine if there are differences between actual RCT and predicted value of RCT considering physical factors in dogs with acute or chronic renal disease. We also aimed to demonstrate whether the RCT and Ao ratio index would be useful for evaluating renal pathology. A total of 54 dogs with acute or chronic renal disease and 30 normal healthy dogs were included in this study. The RCT was measured at the center of the renal pyramid as the shortest distance perpendicular to the renal capsule from the base of the renal medullary pyramid at three points. The diameter of the Ao was measured just caudal to the branch of the left renal artery in the sagittal plane in systole. The RCT:Ao ratio of chronic kidney disease (CKD) patients was 0.50 ± 0.11 (mean ± standard deviation). The RCT:Ao ratio in normal dogs was 0.67 ± 0.07. The RCT:Ao ratio in patients with acute kidney injury (AKI) was 0.83 ± 0.05. There was a statistically significant difference between normal dogs and dogs with CKD (P < 0.001) and between normal dogs and dogs with AKI (P < 0.001). In conclusion, findings from the current study supported using the RCT:Ao ratio as a non‐invasive quantitative method for characterizing kidney pathology in dogs with acute or chronic renal disease.

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“…Higher spatial and temporal resolution of new MRI sequences permit a regional analysis of the kidney function by a separate investigation of the cortical and medullary perfusion. Several studies examined the potential of dynamic perfusion MRI to assess normal kidney perfusion [30], the effect of renal obstruction [31], of renal artery stenosis [32], kidney transplant rejection [33] and renal failure [34]. …”

Section: Technical Aspectsmentioning

confidence: 99%

Magnetic Resonance Imaging of Renal Disease: Recent Developments and Future Applications

Fenchel

Nael²,

Herget–Rosenthal

et al. 2006

Nephron Clin Pract

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Magnetic resonance imaging (MRI) offers the ability to non-invasively assess parenchymal and vascular renal disease. Indications for renal MRI include the evaluation of renal masses, urinary obstruction and infection, renal vasculature, and the health of transplant kidneys. The potential of MR angiography to replace invasive conventional x-ray angiography has been recognized for many years. Recent developments in MRI resulting from fast MR systems with faster gradients, new surface coil designs and the latest sequence developments coupled with innovative contrast agent administration strategies have prompted substantial progress of MRI in the diagnosis of renal disease. The goal of this article is to present the current state of MRI in diagnosing renal disease, with an emphasis on the latest developments in the evaluation of renal vascular disease.

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Functional Assessment of Canine Kidneys After Acute Vascular Occlusion on Gd-DTPA–Enhanced Dynamic Echo-Planar MR Imaging

Cited by 10 publications

References 23 publications

Functional evaluation of normothermic ischemia and reperfusion injury in dog kidney by combining MR diffusion‐weighted imaging and Gd‐DTPA enhanced first‐pass perfusion

Functional evaluation of normothermic ischemia and reperfusion injury in dog kidney by combining MR diffusion‐weighted imaging and Gd‐DTPA enhanced first‐pass perfusion

Ultrasonographic quantitative evaluation of acute and chronic renal disease using the renal cortical thickness to aorta ratio in dogs

Magnetic Resonance Imaging of Renal Disease: Recent Developments and Future Applications

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