Functional Assembly of a Microbial Consortium with Autofluorescent and Mineralizing Activity for the Biodegradation of Organophosphates

Yang, Chao; Li, Chaokun; Li, Lin; Zhao, Qiao; Qiao, Chuanling

doi:10.1021/jf801684g

Cited by 20 publications

(10 citation statements)

References 48 publications

(67 reference statements)

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“…Synthetic microbial consortia have been used as an alternative to naturally occurring communities to improve and accelerate the biodegradation of pollutants 98; 99; 100; 101; 102 . For example, a co-culture of a genetically engineered Escherichia coli and a wild-type Ochrobactrum sp.…”

Section: Applications Of Synthetic Ecology In Biomedicine Metabolic mentioning

confidence: 99%

Synthetic Ecology of Microbes: Mathematical Models and Applications

Zomorrodi

Segrè

2016

Journal of Molecular Biology

195

165

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As the indispensable role of natural microbial communities in many aspects of life on Earth is uncovered, the bottom-up engineering of synthetic microbial consortia with novel functions is becoming an attractive alternative to engineering single-species systems. Here, we summarize recent work on synthetic microbial communities with a particular emphasis on open challenges and opportunities in environmental sustainability and human health. We next provide a critical overview of mathematical approaches, ranging from phenomenological to mechanistic, which can be used to decipher the principles that govern the function, dynamics and evolution of microbial ecosystems. Finally, we present our outlook on key aspects of microbial ecosystems and synthetic ecology that require further developments, including the need for more efficient algorithms and a better integration of empirical methods and model-driven analysis, the importance of improving gene function annotation, and the value of a standardized library of well-characterized organisms to be used as building blocks of synthetic communities.

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Section: Applications Of Synthetic Ecology In Biomedicine Metabolic mentioning

confidence: 99%

Synthetic Ecology of Microbes: Mathematical Models and Applications

Zomorrodi

Segrè

2016

Journal of Molecular Biology

195

165

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“…The data confirm that the mineralization process of MP is initiated by hydrolysis leading to the generation of PNP and dimethylthiophosphoric acid, and PNP degradation, then, proceeds through the formation of hydroquinone. The accumulation of PNP in suspended culture was prevented [44]. A bacterial consortium of seven (out of 64) Enterobacteriaceae isolates including Citrobacter, Enterobacter and Proteus vulgaris capable of degrading methyl parathion.…”

Section: Gene and Genetic Engineeringmentioning

confidence: 99%

Review on Bioremediation of Methyl Parathion Contaminated Agricultural Soil by Microorganisms

2017

IJAPSA

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Organophosphate pesticides are widely used for crop protection against pests and also to increase crop productivity. Methyl parathion (O, O-dimethyl O-p-nitrophenyl phosphorothioate, MP) is one such organophosphate pesticide. The extensive use of it has led to bioaccumulation in the environment. Thus causing harmful health hazards like inhibition of acetylcholinesterase (an important enzyme in nervous system) activity. Bioremediation, a technique can be applied to overcome bioaccumulation caused by pesticide. The present review is focused on the bioremediation of methyl parathion by degradation through potential soil bacteria and culturing them by immobilization. Also the new perspectives for the bioremediation would enhance in effective degradation of methyl parathion.

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“…The most studied enzyme capable of hydrolyzing organophosphates pesticides is OPH, which is encoded by the opd (organophosphate-degrading) gene of Flavobacterium sp. ATCC 27551 and Pseudomonas diminuta MG (Zhang et al 2008;Malghani et al 2009;Schofield and DiNovo 2010 or Mn 2+ without loss of catalytic activity (Benning et al 2000;Scott et al 2008). The proposed catalytic mechanism of this enzyme is shown in Fig.…”

Section: Bacterial Degradation Of Organophosphate Pesticidesmentioning

confidence: 99%