Functional aspects of mast cells, mediator contents and mediator effects

Jc, Foreman

doi:10.3109/00016488409122888

Acta Oto-Laryngologica

1984

DOI: 10.3109/00016488409122888

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Functional aspects of mast cells, mediator contents and mediator effects

Foreman Jc

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1993

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Cited by 3 publications

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“…Despite the noteworthy studies on the association between male fertility and mast cells, the actual role of mast cells in male infertility has not been clearly understood [1]. Yet, mast cells play a role in a number of physio-pathological events [4].…”

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confidence: 99%

The Mast Cells in Semen: Their Effects on Sperm Motility

Cıncık

Sezen

2003

Archives of Andrology

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This study was conducted to evaluate any possible association between mast cells and sperm concentration, morphology, and motility. The study comprised 400 patients who had applied for semen analysis. To evaluate mast cells, 6 smear slides were prepared for each subject and stained with 1% toluidin blue-pyronine (pH 4). The slides revealing any mast cells were labeled as mast+. Concentration and motility was evaluated through a Makler chamber. Kruger's strict criteria were used in morphometric analysis. The mean age of 86 mast+ cases (21% of total patients) was 31+/-6.7; progressive sperm motility rate was 33+/-21.2. The mean concentration was 32+/-30.2 x 10(6)/mL, and normal sperm percentage was 11.8+/-6.5. Progressive sperm motility rate in the mast- cases were 53+/-25. The mean age of mast cell+ patients was higher than that of mast cell- patients (t=3.57, p<.001), while they had lower sperm concentration (p>.05) and lower normal morphologic sperm rate (t=2.26, p<.024), compared to mast cell- patients. The relation between mast cell+ and mast cell- cases and sperm progressive motility was statistically significant (t=6.44, p<.001). It was concluded that sperm parameters were negatively affected by mast cells.

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confidence: 99%

The Mast Cells in Semen: Their Effects on Sperm Motility

Cıncık

Sezen

2003

Archives of Andrology

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Les polynucléaires basophiles et les mastocytes

Ponvert

Paupe²

1993

Revue Française d'Allergologie et d'Immunologie Clinique

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Effect of Salbutamol, Fenoterol, and Sodium Cromoglycate on the Release of Heparin from Sensitized Human Lung Fragments Challenged with Dermatophagoides pteronyssinus Allergen

Green

Konnaris²,

Woolcock³

1993

Am J Respir Cell Mol Biol

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Heparin from degranulating mast cells influences a wide range of cellular and humoral reactions associated with allergic inflammation and asthma. Agents that inhibit mast cell degranulation may therefore compromise the moderating effects of heparin in the tissues and result in worsening inflammation and other associated pathology. This study measures heparin release from allergen-challenged human lung tissue and compares the effect of the mast cell stabilizing beta 2-agonists, salbutamol and fenoterol, and a non-beta 2-agonist, sodium cromoglycate, on the release of heparin. Pieces of lung tissue 2 to 3 mm3 were sensitized with high titer Dermatoaphagoides pteronyssinus-specific IgE serum and challenged with D. pteronyssinus allergen, with and without prior addition of salbutamol, fenoterol, or sodium cromoglycate. Dextran sulfate was added to the mixture to prevent the binding of heparin to tissue proteins. Heparin was released together with histamine after challenge. The mean and 95% confidence interval of prechallenge and postchallenge heparin concentrations in the lung tissue filtrates were 0.10 IU/ml (0.07, 0.12) and 0.24 IU/ml (0.17, 0.30), respectively (P < 0.001). Addition of the beta 2-agonists produced a mean inhibition of released heparin of 71% (50, 92), and 73% (55, 91), respectively. Sodium cromoglycate gave a 35% (20, 51) inhibition that was significantly less than that produced by the beta 2-agonists (P < 0.01). The beta 2-agonists salbutamol and fenoterol strongly inhibited heparin release from mast cells. The therapeutic use of mast cell stabilizing agents may therefore be potentially detrimental to the control of allergic inflammation and other associated pathologies.

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Functional aspects of mast cells, mediator contents and mediator effects

Cited by 3 publications

References 40 publications

The Mast Cells in Semen: Their Effects on Sperm Motility

The Mast Cells in Semen: Their Effects on Sperm Motility

Les polynucléaires basophiles et les mastocytes

Effect of Salbutamol, Fenoterol, and Sodium Cromoglycate on the Release of Heparin from Sensitized Human Lung Fragments Challenged with Dermatophagoides pteronyssinus Allergen

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