Functional Application of the Single-Module NRPS-like d-Alanyltransferase in Maytansinol Biosynthesis
Zhongyue Li,
Zhonghang Zhu,
Guangsen Xu
et al.
Abstract:Single-module nonribosomal peptide synthetases (NRPSs) have nonclassical domain compositions and play versatile roles in the biosynthesis of natural products. AstC, a prototypical single-module NRPS-like D-alanyltransferase with the architecture of adenylation-thiolation-thioesterase (A-T-TE) tridomain, was identified as the catalyst in the D-alanylation process during the post-polyketide synthase (PKS) modifications of ansatrienin biosynthesis. In this study, the function of the TE domain of AstC was elucidat… Show more
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