“…Based on the above results, we analyze that the antimicrobial activity of the avor derivatives may be caused by the following reasons. Since thioether is a type of important pharmacophore, 27,28 the 2-methyl-3-furyl sulde motif mainly contribute to the antimicrobial activity of compounds 3a, 3b, 3d, 3e, 3f, 3g, 3h, 3i, 3j, 3k, 3l, 3m, 5a, 5b, and 5f. As amides oen possess certain bioactivity, the amide unit in these compounds (3d, 3e, 3f, 3g, 3h, 3i) may also help to improve the antimicrobial activity.…”