Functional annotation of colon cancer risk SNPs

Yao, Lijing; Tak, Yu Gyoung; Berman, Benjamin P.; Farnham, Peggy J.

doi:10.1038/ncomms6114

Cited by 104 publications

(97 citation statements)

References 60 publications

(82 reference statements)

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“…ITO and AZO are conductive oxides which are commonly used as transparent electrodes in optoelectronic devices, and which have more recently been proposed as conductive additives for Li-S batteries. 7,16 Previous studies have found polar hosts, such as metal oxide, to bind more strongly to lithium sulfide than does non-polar carbon. Therefore, ITO and AZO would be expected to have lower energy barriers and smaller overpotentials for nucleation.…”

Section: Resultsmentioning

confidence: 99%

“…In many published studies, the electrolyte/sulfur (E/S) ratio can be 10 mL/g or more. [6][7][8] At such a ratio, the large excess of electrolyte results in pack-level specific energy and energy density of less than ∼100 Wh/kg and 100 Wh/L, lower than that of present lithium-ion batteries, negating the theoretical advantage of the lithium-sulfur chemistry. By comparison, reducing the E/S ratio to 1 mL/g would enable up to ∼400 Wh/kg and 400 Wh/L.…”

mentioning

confidence: 99%

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Electrodeposition Kinetics in Li-S Batteries: Effects of Low Electrolyte/Sulfur Ratios and Deposition Surface Composition

Fan

Chiang

2017

J. Electrochem. Soc.

158

127

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Lithium-sulfur batteries obtain most of their capacity from the electrodeposition of Li 2 S. This is often a slow process, limiting the rate capability of Li-S batteries. In this work, the kinetics of Li 2 S deposition from polysulfide solutions of 1-7 M S concentration onto carbon and two conductive oxides (indium tin oxide, ITO; and aluminum-doped zinc oxide, AZO) were characterized. Higher polysulfide concentrations were found to result in significantly slower electrodeposition, with island nucleation and growth rates up to 75% less than at low concentrations. Since Li-S batteries with low electrolyte/sulfur (E/S) ratios necessarily reach higher polysulfide concentrations during use, the present results explain why high polarization and low rate capability are observed under such conditions. Given that low E/S ratios are critical to reach high energy density, means to improve electrodeposition kinetics at high polysulfide concentrations are necessary. Towards this goal, coatings of ITO and AZO on carbon fiber current collectors were found to improve island growth rates at 5 M by up to ∼60%. Of the two oxides, AZO was found to be superior in reducing the electrodeposition overpotential. Its benefits were demonstrated for carbon fiber current collectors coated with AZO and for conductive suspensions incorporating carbon black and nanoparticle AZO. Lithium-sulfur batteries are a promising technology for low-cost, high-density electrochemical energy storage beyond lithium-ion because of sulfur's high abundance, low cost, and high specific capacity (1670 mAh/g). The latter can enable, with a lithium metal negative electrode, a theoretical (active materials only) energy density of ∼2199 Wh/L or 2567 Wh/kg, with projected pack-level values of around 200-450 Wh/kg, which is significantly higher than that of current Li-ion batteries.1-5 Energy density is highly dependent on the electrolyte content of the battery, however. In many published studies, the electrolyte/sulfur (E/S) ratio can be 10 mL/g or more.6-8 At such a ratio, the large excess of electrolyte results in pack-level specific energy and energy density of less than ∼100 Wh/kg and 100 Wh/L, lower than that of present lithium-ion batteries, negating the theoretical advantage of the lithium-sulfur chemistry. By comparison, reducing the E/S ratio to 1 mL/g would enable up to ∼400 Wh/kg and 400 Wh/L.2 Excess electrolyte also contributes additional cost to the battery. Unfortunately, several studies have also found that low electrolyte/sulfur ratio is correlated with poor rate capability and cycle life. 6,9 Many of the challenges facing Li-S batteries arise from a charge/discharge mechanism that is fundamentally different from the intercalation reactions of conventional lithium-ion batteries. Instead, upon lithiation, sulfur first dissolves to form soluble lithium polysulfides Li 2 S x , 4 ≤ x ≤ 8, which are then further reduced to insoluble Li 2 S, which precipitates where the electronic charge transfer necessary for reduction can occur, typically on an electron...

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Electrodeposition Kinetics in Li-S Batteries: Effects of Low Electrolyte/Sulfur Ratios and Deposition Surface Composition

Fan

Chiang

2017

J. Electrochem. Soc.

158

127

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“…Finally, several SNPs associated with a high probability of colorectal cancer were recently identified in the promoters of genes that are highly expressed in tumor versus normal colon tissue (86). One such gene, RAD51AP1, which is involved in homologous DNA repair, was downregulated only by HNF4␣2, while another gene, TERC, which is involved in maintaining telomeres, is upregulated only by HNF4␣8 (Fig.…”

Section: Generation and Characterization Of Isoform-specific Hnf4␣-exmentioning

confidence: 99%

Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells

Vuong

Chellappa

Dhahbi

et al. 2015

Molecular and Cellular Biology

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The nuclear receptor hepatocyte nuclear factor 4␣ (HNF4␣) is tumor suppressive in the liver but amplified in colon cancer, suggesting that it also might be oncogenic. To investigate whether this discrepancy is due to different HNF4␣ isoforms derived from its two promoters (P1 and P2), we generated Tet-On-inducible human colon cancer ( Thus, the HNF4␣ isoforms play distinct roles in colon cancer, which could be due to differential interactions with the Wnt/␤-catenin/TCF4 and AP-1 pathways.

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“…Esta puntualización se hace necesaria considerando que, por ejemplo, el papel biomarcador del IMC puede ser dependiente del género (23,26). A esto se le suma el conocimiento creciente sobre el papel de determinados polimorfismos de un solo nucleótido (SNP de las siglas en inglés Single Nucleotide Polymorphism) sobre el riesgo de recurrencia o supervivencia al CCR (43)(44)(45)(46). Con todo esto, se necesitan estudios de gran cohorte que abarquen pacientes con CCR de diferentes estadios, con diferente genotipo de SNP, de ambos sexos, etc.…”

Section: Discussionunclassified

Biomarcadores de pronóstico modificables nutricionalmente en el paciente con cáncer colorrectal tras el diagnóstico de la enfermedad

Paniagua¹,

Aguilar²,

Keenoy

2017

Nutr Hosp

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Introduction: Colorectal cancer (CRC) is the second most common cancer in the Western world. About one million of new CRC cases are diagnosed per year. The survival rate of patients with CRC changes widely, even among patients with the same tumor histology. This is possibly due to the impact of environmental factors on tumor development. The diet is the most important among these factors. It is known that nutrition can modify the risk of CRC. However, the role that nutrition plays in the risk of recurrence or survival in patients with CRC is not known with accuracy. Objetive: The objective of this review was to try to clarify this fact. Material and methods: Collecting the data obtained as of today in the epidemiological studies of association among recurrence, survival or mortality risk of CRC; and vitamins and the body mass index (BMI), to develop a series of nutritional advices to patients. Conclusions: Thanks to the studies discussed in this work, we could conclude that: BMI, retinol and vitamin D, and in some cases folic acid, at the time of disease diagnosis, operate like recurrence and survival prognosis markers in CRC.

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Functional annotation of colon cancer risk SNPs

Cited by 104 publications

References 60 publications

Electrodeposition Kinetics in Li-S Batteries: Effects of Low Electrolyte/Sulfur Ratios and Deposition Surface Composition

Electrodeposition Kinetics in Li-S Batteries: Effects of Low Electrolyte/Sulfur Ratios and Deposition Surface Composition

Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells

Biomarcadores de pronóstico modificables nutricionalmente en el paciente con cáncer colorrectal tras el diagnóstico de la enfermedad

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