Functional and structural properties of human patellar articular cartilage in osteoarthritis

Nissinen, Mikko T.; Hänninen, Nina; Prakash, Mithilesh; Mäkelä, Janne; Nissi, Mikko J.; Töyräs, Juha; Nieminen, Miika T.; Korhonen, Rami K.; Tanska, Petri

doi:10.1016/j.jbiomech.2021.110634

Cited by 10 publications

(7 citation statements)

References 41 publications

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“…We also compared the femoral condyle cartilage FRPE parameters to other locations in the knee 9,39 and hip 36 joints (Figure 3). In normal femoral condyle cartilage, the initial permeability and permeability strain-dependency coefficient were 5.64 (95% CI 2.72, 8.53) 9 10 215 m 4 N 21 s 21 and 7.71 (95% CI 3.39, 12.01) greater compared to those in the tibial plateau cartilage respectively, while the strain-dependent fibril network modulus of femoral condyle cartilage was 11.64 (95% CI 3.61, 19.67) MPa smaller compared to those in the tibial plateau cartilage (Supplementary Material Table S3).…”

Section: Constituent-specific Fibril-reinforced Poroelasticmentioning

confidence: 99%

“…We also acknowledge that the samples that are harvested from different donors with different gender, age and OA subtypes might affect the validity of the comparison of mechanical properties between human femoral cartilage (this study) and other cartilage sites, 9,39 and thus, the conclusion made based on these comparisons may not be necessarily generalized.…”

Section: Limitationsmentioning

confidence: 99%

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Elastic, Dynamic Viscoelastic and Model-Derived Fibril-Reinforced Poroelastic Mechanical Properties of Normal and Osteoarthritic Human Femoral Condyle Cartilage

et al. 2021

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Osteoarthritis (OA) degrades articular cartilage and weakens its function. Modern fibril-reinforced poroelastic (FRPE) computational models can distinguish the mechanical properties of main cartilage constituents, namely collagen, proteoglycans, and fluid, thus, they can precisely characterize the complex mechanical behavior of the tissue. However, these properties are not known for human femoral condyle cartilage. Therefore, we aimed to characterize them from human subjects undergoing knee replacement and from deceased donors without known OA. Multi-step stress-relaxation measurements coupled with sample-specific finite element analyses were conducted to obtain the FRPE material properties. Samples were graded using OARSI scoring to determine the severity of histopathological cartilage degradation. The results suggest that alterations in the FRPE properties are not evident in the moderate stages of cartilage degradation (OARSI 2-3) as compared with normal tissue (OARSI 0-1). Drastic deterioration of the FRPE properties was observed in severely degraded cartilage (OARSI 4). We also found that the FRPE properties of femoral condyle cartilage related to the collagen network (initial fibril-network modulus) and proteoglycan matrix (non-fibrillar matrix modulus) were greater compared to tibial and patellar cartilage in OA. These findings may inform cartilage tissue-engineering efforts and help to improve the accuracy of cartilage representations in computational knee joint models.

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Section: Constituent-specific Fibril-reinforced Poroelasticmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Elastic, Dynamic Viscoelastic and Model-Derived Fibril-Reinforced Poroelastic Mechanical Properties of Normal and Osteoarthritic Human Femoral Condyle Cartilage

et al. 2021

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“…This could be related to their differences in terms of cartilage thickness, composition, compressive properties, and permeability. In particular, the thickness of patellar cartilage could determine the fragility of this chondral site with the consequent limited cartilage regeneration after scaffold implantations, plausibly explaining the lower clinical outcomes observed [9, 16]. Based on these results, when evaluating the outcome of cartilage treatments in the patello‐femoral joint, the patellar and trochlear defects should be considered as separate entity, and a specific focus should be put on patellar results, which proved to be particularly challenging.…”

Section: Discussionmentioning

confidence: 99%

Chitosan based scaffold applied in patellar cartilage lesions showed positive clinical and MRI results at minimum 2 years of follow up

Poggi

Martino

Andriolo

et al. 2022

Knee Surg Sports Traumatol Arthrosc

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Purpose New scafold-based cartilage regeneration techniques have been developed to improve the results of microfractures also in complex locations like the patello-femoral joint. The aim of this study was to analyse the results obtained in patellar lesions treated with a bioscafold, a mixture composed by a chitosan solution, a bufer, and the patient's whole blood which forms a stable clot into the lesion. Methods Fifteen patients with ICRS grade 3-4 cartilage lesions of the patellar surface were treated with a chitosan bioscaffold. Fourteen patients were clinically and radiologically evaluated prospectively for a minimum follow-up of 2 years with IKDC, KOOS, Tegner score, and MRI. The mean age of patients at the time of surgery was 31.8 ± 11.9 and nine patients presented degenerative aetiology, four patients with previous trauma, and 1 patient with osteochondritis dissecans. ResultsThe IKDC subjective score improved from 46.2 ± 19.3 preoperatively to 69.5 ± 20.3 (p < 0.05) and 74.1 ± 23.2 (p < 0.05) at 12 and 24 months, respectively. Also KOOS Pain, KOOS Sport/Rec and KOOS QOL showed a signiicant improvement from baseline to 12 months and to the inal follow-up. MRI evaluation showed a complete illing of the cartilage defect at the inal follow-up in 70% of the lesions, obtaining a total MOCART 2.0 score of 71.5 ± 13.6 at 24 months after surgery. Conclusion Chondral patellar lesions represent a complex pathology, with lower results compared to other sites. This bioscafold represents a safe surgical treatment providing a signiicant clinical improvement at 24 months in the treatment of patellar cartilage lesions. Level of evidence IV.

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“…Regarding studies performed on human tissue, the structure-function relationships of healthy and diseased tissue have been studied only in tibial 15 , patellar 38 and hip joint 34 cartilage. Nevertheless, structure-function relationships of human femoral condyle cartilage are still not well explored.…”

Section: Introductionmentioning

confidence: 99%

Associations of human femoral condyle cartilage structure and composition with viscoelastic and constituent-specific material properties at different stages of osteoarthritis

Ebrahimi

Turkiewicz

Finnilä

et al. 2022

Preprint

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The relationships between structure and function in human knee femoral cartilage are not well-known at different stages of osteoarthritis. Thus, we characterized the depth-dependent composition and structure of normal and osteoarthritic human femoral condyle cartilage (n = 47) and related them to their viscoelastic and constituent-specific mechanical properties. We observed that, in superficial cartilage, the collagen network disorganization and proteoglycan loss were associated with the smaller initial fibril network modulus (collagen pretension). Furthermore, the proteoglycan loss was associated with the greater strain-dependent fibril network modulus (a measure of nonlinear mechanical behavior). The proteoglycan loss was also associated with greater cartilage viscosity at a low loading frequency (0.005 Hz), while the disorganization of the collagen network was associated with greater cartilage viscosity at a high loading frequency (1 Hz). Our results suggest that proteoglycan degradation and collagen disorganization reduce the pretension of the collagen network while proteoglycan degradation also increases the nonlinear mechanical response of the collagen network. Further, the results also highlight that proteoglycan degradation and collagen disorganization increase the viscosity of cartilage, but their contribution to increased viscosity occurs in completely different loading frequencies.

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Functional and structural properties of human patellar articular cartilage in osteoarthritis

Cited by 10 publications

References 41 publications

Elastic, Dynamic Viscoelastic and Model-Derived Fibril-Reinforced Poroelastic Mechanical Properties of Normal and Osteoarthritic Human Femoral Condyle Cartilage

Elastic, Dynamic Viscoelastic and Model-Derived Fibril-Reinforced Poroelastic Mechanical Properties of Normal and Osteoarthritic Human Femoral Condyle Cartilage

Chitosan based scaffold applied in patellar cartilage lesions showed positive clinical and MRI results at minimum 2 years of follow up

Associations of human femoral condyle cartilage structure and composition with viscoelastic and constituent-specific material properties at different stages of osteoarthritis

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