Functional and structural brain MRI changes associated with cognitive worsening in multiple sclerosis: a 3-year longitudinal study

Azzimonti, Matteo; Preziosa, Paolo; Pagani, Elisabetta; Valsasina, Paola; Tedone, Nicolò; Vizzino, Carmen; Rocca, Maria A.; Filippi, Massimo

doi:10.1007/s00415-023-11778-z

Cited by 8 publications

(4 citation statements)

References 79 publications

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“…For example, decreased functional connectivity between the left posterior cingulate cortex and right anterior cingulate cortex was found to be associated with longer completion time in Wisconsin Card Sorting Test in bipolar disorder patients [47]. It was also shown that multiple sclerosis patients with worsened cognition had more severe gray matter atrophy in right anterior cingulate cortex compared to cognitively stable multiple sclerosis patients [48]. Additionally, ReHo in right anterior cingulate cortex has been found to be negatively correlated with working memory in schizophrenia patients [45].…”

Section: Discussionmentioning

confidence: 99%

Structural network topology correlates with cognitive impairment in Parkinson’s disease

Chen,

Li,

Zhou

et al. 2023

Preprint

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In patients with Parkinson's disease (PD), cognitive impairment is common and substantially exacerbates disease severity. The objective of this study is to investigate whether cognitive decline affects disease severity and whether structural network disruption contributes to cognitive impairment in PD patients. PD patients (n = 146) receiving structural and functional magnetic resonance imaging from Parkinson's Progression Markers Initiative (PPMI) database were included. Based on the scores of Symbol Digit Modalities Test (SDMT), patients were classified into lower quartile group (SDMT score rank: 0%~25%), interquartile group (SDMT score rank: 26%~75%), and upper quartile group (SDMT score rank: 76%~100%) according to their SDMT score quartiles to assess how cognitive function shapes disease manifestations and brain network topology. Patients in the lower quartile group exhibited more severe motor symptoms, non-motor symptoms, and striatal dopamine depletion compared to interquartile group and upper quartile group. In addition, they also showed impaired structural network topology both at global and local levels compared to interquartile group and upper quartile group. Furthermore, different nodal network metrics in structural network contributed to cognitive and motor impairment of PD patients. Taken together, PD patients with worse cognitive function exhibited more severe motor and non-motor symptoms and aberrant structural network metrics were associated with both cognitive and motor decline of PD patients.

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Section: Discussionmentioning

confidence: 99%

Structural network topology correlates with cognitive impairment in Parkinson’s disease

Chen,

Li,

Zhou

et al. 2023

Preprint

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“… 67 Moreover, ToM performance was related to cortical thickness in the lingual gyrus, the cingulate, and the cuneus, as well as volume in the putamen, the pallidum, and the amygdala: as for facial emotion recognition, higher performers showed a significantly greater cortical thickness and volume in these regions compared to lower performers. Cingulate is one of the brain areas most related to social abilities, 35 , 65 , 66 in particular involved in ToM, 67 , 68 as well as other cognitive deficits in MS patients, 58 , 69 , 70 , 71 , 72 , 73 probably since it is one of the first regions becoming atrophic in relapsing–remitting MS patients. 64 In addition to the abovementioned amygdala, the pallidum appeared to be a subcortical structure influencing ToM performance, in agreement with a previous study evaluating MRI correlates of ToM abilities.…”

Section: Discussionmentioning

confidence: 99%

The neural substrates of social cognition deficits in newly diagnosed multiple sclerosis patients

Ziccardi,

Genova,

Colato

et al. 2024

Ann Clin Transl Neurol

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ObjectiveCognitive and affective symptoms in multiple sclerosis (MS) can be independently impaired and have different pathways of progression. Cognitive alterations have been described since the earliest MS stages; by contrast, the social cognition (SC) domain has never been investigated in the first year from MS diagnosis. We aimed to evaluate SC and unravel its neural bases in newly diagnosed MS patients.MethodsSeventy MS patients underwent at diagnosis a 3 T‐MRI and a neuropsychological/SC assessment (median time between diagnosis and MRI/cognitive evaluation = 0 months). We tested two matched reference samples: 31 relapsing–remitting MS patients with longer course (mean ± SD disease duration = 7.0 ± 4.5 years) and 38 healthy controls (HCs). Cortical thicknesses (CTh) and volumes of brain regions were calculated.ResultsNewly diagnosed MS patients performed significantly lower than HCs in facial emotion recognition (global: p < 0.001; happiness: p = 0.041, anger: p = 0.007; fear: p < 0.001; disgust: p = 0.004) and theory of mind (p = 0.005), while no difference was found between newly diagnosed and longer MS patients. Compared to lower performers, higher performers in facial emotion recognition showed greater volume of amygdala (p = 0.032) and caudate (p = 0.036); higher performers in theory of mind showed greater CTh in lingual gyrus (p = 0.006), cuneus (p = 0.024), isthmus cingulate (p = 0.038), greater volumes of putamen (p = 0.016), pallidum (p = 0.029), and amygdala (p = 0.032); patients with higher empathy showed lower cuneus CTh (p = 0.042) and putamen volume (p = 0.007).InterpretationsSC deficits are present in MS patients since the time of diagnosis and remain persistent along the disease course. Specific basal, limbic, and occipital areas play a significant role in the pathogenesis of these alterations.

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“…It has been shown that MS patients with cognitive decline exhibit more pronounced GM atrophy in the right anterior cingulate cortex and bilateral supplementary motor area. Additionally, they have reduced resting state functional connectivity in the right hippocampus of the right working memory network and in the right insula of the default mode network [ 41 , 42 ]. Several diffusion MRI studies suggest a decrease in topological efficiency (a measure of network integration) within the structural connectome of MS patients.…”

Section: Assessment and Disease Scoring Systemsmentioning

confidence: 99%

Impact of Cognitive Impairment on Quality of Life in Multiple Sclerosis Patients—A Comprehensive Review

Gómez-Melero,

Caballero-Villarraso,

Escribano

et al. 2024

JCM

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Multiple sclerosis (MS) is characterized by a variety of symptoms that have a major impact on quality of life (QoL) even in early stages. In addition to individual motor, sensory, visual disturbances, and brainstem and sphincter disorders, which are expressed through the widely used Expanded Disability Status Scale (EDSS), other manifestations of MS have a detrimental effect on overall functioning and quality of life, such as cognitive impairment, depression, anxiety, fatigue, and pain. However, when talking about QoL, categorical definitions cannot be used because although the concept is generally understood, it is highly nuanced. Suffering from MS can significantly reduce QoL. Numerous research studies have focused on trying to identify and assess which are the elements that most affect the loss of QoL in MS people. However, in addition to the fact that the measurement of QoL can be subjective, it is very difficult to consider these elements in isolation, as they are interrelated. One such limiting factor of QoL that has been investigated is cognitive impairment (CI). This has been shown to have an impact on the lives of MS people, although the different approaches that have been taken to assess CI have evident limitations.

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Functional and structural brain MRI changes associated with cognitive worsening in multiple sclerosis: a 3-year longitudinal study

Cited by 8 publications

References 79 publications

Structural network topology correlates with cognitive impairment in Parkinson’s disease

Structural network topology correlates with cognitive impairment in Parkinson’s disease

The neural substrates of social cognition deficits in newly diagnosed multiple sclerosis patients

Impact of Cognitive Impairment on Quality of Life in Multiple Sclerosis Patients—A Comprehensive Review

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