Functional and structural age‐related changes in the scalp skin of Caucasian women

Pouradier, Florence; Cornillon, C.; D'arras, Marie-Florence; Flament, Frédéric; Panhard, S.; Diridollou, S.; Loussouarn, G.

doi:10.1111/srt.12057

Cited by 25 publications

(14 citation statements)

References 32 publications

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“…Similarly, ageing process clearly affects sebum production, by an almost regular decline of SGs activity along the lifespan, at an even faster rate in Caucasian women . A previous study supports such findings .…”

Section: Discussionsupporting

confidence: 57%

The worldwide diversity of scalp seborrhoea, as daily experienced by seven human ethnic groups

Pouradier

Liu

Wares

et al. 2017

Intern J of Cosmetic Sci

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Section: Discussionsupporting

confidence: 57%

The worldwide diversity of scalp seborrhoea, as daily experienced by seven human ethnic groups

Pouradier

Liu

Wares

et al. 2017

Intern J of Cosmetic Sci

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“…The ratio Ur/Ue was used to represent skin elasticity as described previously 28 . Cheek images were acquired with an ultrasonic Echograph B-scan equipped with a high-frequency broadband transducer working at 25 MHz and providing axial resolution of 75 µm at −6 dB 53 , 54 . Skin thickness was measured and the ultrasound characterization of the dermis was quantified with in-house software.…”

Section: Methodsmentioning

confidence: 99%

Aging-related changes in the diversity of women’s skin microbiomes associated with oral bacteria

Shibagaki¹,

Suda

Clavaud

et al. 2017

Sci Rep

155

162

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Skin aging is associated with changes in cutaneous physiology including interactions with a skin microbial community. A striking alteration and diversification in the skin microbiome with aging was observed between two different age groups of 37 healthy Japanese women, i.e. younger adults of 21–37 years old and older adults of 60–76 years old, using bacterial 16S rRNA gene sequencing. The analyses revealed that the alpha diversity/species richness was significantly higher in the older than the younger group for the cheek and forehead microbiomes, while the beta diversity in the overall structure significantly differed particularly for the forearm and scalp microbiomes between the two age groups. Taxonomic profiling showed a striking reduction in the relative abundance of the majority skin genus Propionibacterium in the cheek, forearm and forehead microbiomes of the older adults, and identified 38 species including many oral bacteria that significantly differentiated the two age groups with a skin site dependency. Furthermore, we found chronological age-related and unrelated skin clinical parameters that correlate with the observed changes in the skin microbiome diversity. Thus, our data suggested that the diversification of skin microbiomes in adult women was largely affected by chronological and physiological skin aging in association with oral bacteria.

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“…In previous years our groups was able to establish an excellent correlation regarding the amount of hair follicles available, as well as the quantitative follicular uptake of nanoparticles between pig ear tissue in vitro and human forearm skin in vivo [29]. However, it is noteworthy that the amount of terminal hairs available for this type of therapy on the average human scalp is much higher than what is seen on porcine ear skin (124-200 hairs per cm 2 on human occipital scalp vs. 11-25 cm 2 on porcine ear skin) [43][44][45]. Therefore, an even higher follicular recovery and potential for a depot effect on the scalp is to be expected in vivo, only further corroborating the potential of this type of application for the above mentioned conditions.…”

Section: Potential Of Nanocarriers From a Clinical Perspectivementioning

confidence: 99%

Nanocarriers for optimizing the balance between interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverse effects

Mathes

Melero

Conrad

et al. 2016

Journal of Controlled Release

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The treatment of various hair disorders has become a central focus of good dermatologic patient care as it affects men and women all over the world. For many inflammatory-based scalp diseases, glucocorticoids are an essential part of treatment, even though they are known to cause systemic as well as local adverse effects when applied topically. Therefore, efficient targeting and avoidance of these side effects are of utmost importance. Optimizing the balance between drug release, interfollicular permeation, and follicular uptake may allow minimizing these adverse events and simultaneously improve drug delivery, given that one succeeds in targeting a sustained release formulation to the hair follicle. To test this hypothesis, three types of polymeric nanocarriers (nanospheres, nanocapsules, lipid-core nanocapsules) for the potent glucocorticoid Clobetasol propionate (CP) were prepared. They all exhibited a sustained release of drug, as was desired. The particles were formulated as a dispersion and hydrogel and (partially) labeled with Rhodamin B for quantification purposes. Follicular uptake was investigated using the Differential Stripping method and was found highest for nanocapsules in dispersion after application of massage. Moreover, the active ingredient (CP) as well as the nanocarrier (Rhodamin B labeled polymer) recovered in the hair follicle were measured simultaneously, revealing an equivalent uptake of both. In contrast, only negligible amounts of CP could be detected in the hair follicle when applied as free drug in solution or hydrogel, regardless of any massage. Skin permeation experiments using heat-separated human epidermis mounted in Franz Diffusion cells revealed equivalent reduced transdermal permeability for all nanocarriers in comparison to application of the free drug. Combining these results, nanocapsules formulated as an aqueous dispersion and applied by massage appeared to be a good candidate to maximize follicular targeting and minimize drug penetration into the interfollicular epidermis. We conclude that such nanotechnology-based formulations provide a viable strategy for more efficient -2-drug delivery to the hair follicle. Moreover, they present a way to minimize adverse effects of potent glucocorticoids by releasing the drug in a controlled manner and simultaneously decreasing interfollicular permeation, offering an advantage over conventional formulations for inflammatorybased skin/scalp diseases. Graphical Abstract AbbreviationsAA: Alopecia areata ANOVA: Analysis of variance CCT: capric/caprylic triglyceride CP: Clobetasol propionate

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Functional and structural age‐related changes in the scalp skin of Caucasian women

Abstract: With ageing, some few functional and structural changes are observed in the scalp of Caucasian women. Similarities or differences with those previously reported in other skin sites are discussed.

Cited by 25 publications

References 32 publications

The worldwide diversity of scalp seborrhoea, as daily experienced by seven human ethnic groups

The worldwide diversity of scalp seborrhoea, as daily experienced by seven human ethnic groups

Aging-related changes in the diversity of women’s skin microbiomes associated with oral bacteria

Nanocarriers for optimizing the balance between interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverse effects

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