Functional and morphological regeneration of olfactory tracts and subtracts in goldfish

Zippel, H. P.; Hofmann, Michaël; Meyer, Dietrich; Zeman, Sophie

doi:10.1007/bf00214718

Cited by 12 publications

(2 citation statements)

References 26 publications

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“…Lesions for the behavioural experiments were made bilaterally. Details of the standardized apparatus for shock-free training are described elsewhere (Zippel et al 1981(Zippel et al , 1993a. During the entire pre-and post-operative tests and training periods, gold¢sh were kept in groups of two in separate single aquaria (130 cm £ 30 cm £ 20 cm) under a 12 L:12 D cycle at ca.…”

Section: Methodsmentioning

confidence: 99%

In goldfish the discriminative ability for odours persists after reduction of the olfactory epithelium, and rapidly returns after olfactory nerve axotomy and crossing bulbs

Zippel

2000

Phil. Trans. R. Soc. Lond. B

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Gold¢sh are ideal vertebrates for the study of regeneration within the peripheral and the central olfactory system. The present behavioural investigations studied the e¡ects of bilateral lesions on the animals' ability to qualitatively discriminate two amino acids (10 7 6 M) and their performance in two more di¤cult tasks: (i) rewarded amino acid applied in a lower concentration, and (ii) rewarded stimulus contaminated. A 50 and 85% reduction of the olfactory epithelium resulted in no recordable behavioural de¢cit. After axotomy of olfactory nerves and lateral olfactory tractotomy, ¢shes were anosmic for seven to ten days. Following replacement of sensory cells in the epithelium, and after regeneration of olfactory tract ¢bres a full functional recovery, i.e. a highly speci¢c regeneration, was recorded. After three surgical modi¢cations of the olfactory bulbs' position, (i) crossing olfactory tracts and bulbs, (ii) crossing tracts and turning bulbs, and (iii) turning bulbs upside down, a full functional recovery was recorded for amino-acid discrimination in a similar concentration. A permanent, and similar slight de¢cit was, however, found during application of di¡erent concentrations, and of contaminated stimuli when medial lateral halves of the bulb were in`incorrect' position (i) and (iii), or olfactory bulbs were positioned in the vicinity of the contralateral epithelium (i) and (ii).

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Section: Methodsmentioning

confidence: 99%

In goldfish the discriminative ability for odours persists after reduction of the olfactory epithelium, and rapidly returns after olfactory nerve axotomy and crossing bulbs

Zippel

2000

Phil. Trans. R. Soc. Lond. B

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“…First, a reasonable upper limit for the time required for detectable plastic changes in the brain was established. We based this on the time required to regenerate an olfactory bulb damaged by lesioning, approximately 3 weeks in zebrafish (Danio rerio (Hamilton, 1822)), or complete removal, 4 weeks in goldfish (Carassius auratus (Linnaeus, 1758)) (Zippel et al 1993;Paskin et al 2011). Second, a lower limit was suggested by work in threespine sticklebacks (Gasterosteus aculeatus Linnaeus, 1758), which after 6 days of exposure to predator cues had significant transcriptomic changes in their brain tissue (Sanogo et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Rapid plastic changes in brain morphology in response to acute changes in predation pressure in juvenile Atlantic salmon (Salmo salar) and northern redbelly dace (Phoxinus eos)

Joyce

Brown

2020

Can. J. Zool.

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Teleosts exhibit inter- and intra-specific variation in the size and shape of their brains. Interpopulation differences in gross brain morphology among numerous teleost fish species have been observed and have been partially attributed to plastic changes in response to their environment, including predation. These differences manifest themselves macroscopically, potentially because teleosts retain the capacity for active neuroproliferation into adulthood. Building on previous work, showing chronic exposure to predation can affect brain morphology, we sought to determine whether these differences manifest themselves on a time scale shown to induce phenotypically plastic behavioural changes. In separate trials, we held northern redbelly dace (Phoxinus eos (Cope, 1861) = Chrosomus eos Cope, 1861) and juvenile Atlantic salmon (Salmo salar Linnaeus, 1758) in semi-natural conditions and exposed them to conspecific skin extract as a proxy for predation risk over 2 weeks. After exposure, their brains were excised, photographed, and analyzed for size (multivariate ANOVA) and shape (Procrustes ANOVA). Despite their brief exposure to simulated predation pressure, subjects from both species developed significantly different brain morphologies. Compared with controls, the Atlantic salmon exhibited a different brain shape and smaller optic tecta, whereas the northern redbelly dace had larger brains with more developed olfactory bulbs and optic tecta. Our results highlight the rapidity with which external environment can alter patterns of growth in the brain.

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Regeneration of the Olfactory Tract Following Neonatal Lesion in Rats

Munirathinam

Rao

Yende

et al. 1997

Experimental Neurology

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Functional and morphological regeneration of olfactory tracts and subtracts in goldfish

Cited by 12 publications

References 26 publications

In goldfish the discriminative ability for odours persists after reduction of the olfactory epithelium, and rapidly returns after olfactory nerve axotomy and crossing bulbs

In goldfish the discriminative ability for odours persists after reduction of the olfactory epithelium, and rapidly returns after olfactory nerve axotomy and crossing bulbs

Rapid plastic changes in brain morphology in response to acute changes in predation pressure in juvenile Atlantic salmon (Salmo salar) and northern redbelly dace (Phoxinus eos)

Regeneration of the Olfactory Tract Following Neonatal Lesion in Rats

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