Functional and morphological characterization of neuropathy induced with 5-Lipoxygenase inhibitor CGS 21595

Classen, W.; Gunson, Diane E.; Iverson, William O.; Traina, Vincent M.; Vonau, Marianne; Krinke, G.

doi:10.1016/s0940-2993(11)80038-2

Cited by 9 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unlike axonal degeneration, which occurs earlier and more severely in distal portions of nerve fibers, segmental demyelination tends to impact proximal nerves (especially spinal nerve roots) since the quantity of myelin to be sustained is greatest in this region. 40…”

Section: Resultsmentioning

confidence: 99%

The Science and Art of Nerve Fiber Teasing for Myelinated Nerves: Methodology and Interpretation

Bolon

Pardo

Krinke³

2019

Toxicol Pathol

View full text Add to dashboard Cite

Nerve fiber teasing is a sensitive technique utilized in diagnostic neuropathology practice, laboratory research, and animal toxicity studies for characterizing changes in single myelinated nerve fibers over extended distances. In animal toxicity studies, a nerve portion (approximately 10 mm in length) is stained with Sudan black for 24 to 48 hours and then transferred into a drop of viscous medium (eg, glycerin) mounted on an adhesive-coated glass slide, positioning it such that the proximodistal orientation is known. Individual fibers are removed using fine forceps while the sample is viewed under a stereomicroscope. In general, lesions can be identified during teasing, but more detailed characterization and photodocumentation is undertaken once nerve fibers have been dried and coverslipped. Nerve fiber teasing is particularly useful for distinguishing early stages of axonal degeneration (which presents as ovoid fiber fragments in the midinternodal region) from segmental demyelination (which presents as loss of original myelin segments and their replacement by thinner, shorter segments in the absence of axonal damage). The slow, laborious nature of nerve fiber teasing dictates that the technique will be employed on a few samples as an auxiliary method to better define the pathogenesis of nerve lesions first identified by conventional histopathologic assessment.

show abstract

Section: Resultsmentioning

confidence: 99%

The Science and Art of Nerve Fiber Teasing for Myelinated Nerves: Methodology and Interpretation

Bolon

Pardo

Krinke³

2019

Toxicol Pathol

View full text Add to dashboard Cite

show abstract

“…Second, a lipoxygenase inhibitor AA861 inhibits neurite outgrowth in neural cells in vitro via inhibition of F-actin function [ 12 ]. Third, Classen et al showed that a lipoxygenase inhibitor CGS21595 causes axonal degeneration and reduction of grip strength in rats [ 13 ], which are remarkably similar to the peripheral nerve damages in CSS [ 2 ]. However, the potential role of leukotrienes on neural repair has hitherto received little attention.…”

Section: Discussionmentioning

confidence: 99%

A Case of Montelukast-Induced Churg-Strauss Syndrome Associated with Liver Dysfunction

Matsumoto

Nishijima

2011

Case Reports in Hepatology

View full text Add to dashboard Cite

A 64-year-old woman was admitted to hospital due to protracted diarrhea and liver dysfunction. The patient was diagnosed as Churg-Strauss syndrome (CSS) due to asthma, paranasal sinusitis, hypereosinophilia, and polyneuropathy. There was a history of taking montelukast, a leukotriene receptor antagonist (LTRA), which is thought to have some relationship with CSS. The liver biopsy specimen showed eosinophilic infiltration and centrolobular fatty change. In this paper, we review the relationship between LTRA and CSS. Several lines of evidence suggest that leukotriene plays an important role in maintaining neural tissues. We also review the potential relationship between centrolobular fatty change and pivoxil-containing antibiotics, which was prescribed for sinusitis before admission. Carnitine deficiency induced by pivoxil-containing agents may cause impaired fatty acid oxidation in mitochondria.

show abstract

“…Grip strength can accurately demonstrate sensorimotor peripheral neuropathy [ 50 ]. It is a reliable indicator of touch and proprioceptive sensation as a function of motor efferent fibers and muscle use [ 51 ].…”

Section: Methodsmentioning

confidence: 99%

Antioxidant and Neuroprotective Effect of a Grape Pomace Extract on Oxaliplatin-Induced Peripheral Neuropathy in Rats: Biochemical, Behavioral and Histopathological Evaluation

et al. 2022

View full text Add to dashboard Cite

Oxaliplatin is a widely used chemotherapeutic agent. Despite its many beneficial aspects in fighting many malignancies, it shares an aversive effect of neuropathy. Many substances have been used to limit this oxaliplatin-driven neuropathy in patients. This study evaluates the neuroprotective role of a grape pomace extract (GPE) into an oxaliplatin induced neuropathy in rats. For this reason, following the delivery of the substance into the animals prior to or simultaneously with oxaliplatin, their performance was evaluated by behavioral tests. Blood tests were also performed for the antioxidant activity of the extract, along with a histological and pathological evaluation of dorsal root ganglion (DRG) cells as the major components of the neuropathy. All behavioral tests were corrected following the use of the grape pomace. Oxidative stressors were also limited with the use of the extract. Additionally, the morphometrical analysis of the DRG cells and their immunohistochemical phenotype revealed the fidelity of the animal model and the changes into the parvalbumin and GFAP concentration indicative of the neuroprotective role of the pomace. In conclusion, the grape pomace extract with its antioxidant properties alleviates the harmful effects of the oxaliplatin induced chronic neuropathy in rats.

show abstract

Functional and morphological characterization of neuropathy induced with 5-Lipoxygenase inhibitor CGS 21595

Cited by 9 publications

References 12 publications

The Science and Art of Nerve Fiber Teasing for Myelinated Nerves: Methodology and Interpretation

The Science and Art of Nerve Fiber Teasing for Myelinated Nerves: Methodology and Interpretation

A Case of Montelukast-Induced Churg-Strauss Syndrome Associated with Liver Dysfunction

Antioxidant and Neuroprotective Effect of a Grape Pomace Extract on Oxaliplatin-Induced Peripheral Neuropathy in Rats: Biochemical, Behavioral and Histopathological Evaluation

Contact Info

Product

Resources

About