Functional and Morphological Changes in Diabetic Macular Oedema: Baseline Correlations, and Changes with Pharmacological Treatments

Abstract

This study aims to evaluate the ability of MAIA MP in detecting early changes in retinal function not only with the analysis of retinal sensitivity, but also with the analysis of fixation behaviour in eyes with diabetic macular oedema, and investigate their correlation with central macular thickness measured with OCT and visual acuity (LogMAR) at baseline and in 3 months from commencing treatment intravitreal anti-VEGF therapies. 23 consecutive patients with clinically significant diabetic macular oedema presenting to the practice of the University Hospital, Queen's Medical Centre, Nottingham, were recruited into this study. The morphological changes and VA data in our cohort confirm the clinical efficacy of treatments of DMO with intravitreal injections of ranibizumab. The morphological changes of macular thickness, intraretinal cysts or subretinal fluid (SRF) on OCT decreased in all internal subfields at 3 months with treatment compared to baseline values. The measurement of visual function with MP may be considered as an important tool to better diagnose retinal pathologies as part of multimodality imaging, responding to the need to combine morpho-functional information, and combining different images from different measurement technologies.