Functional and Morphological Brain Alterations in Dysthyroid Optic Neuropathy: A Combined Resting‐State <scp>fMRI</scp> and Voxel‐Based Morphometry Study

Wu, Hongyu; Luo, Ban; Wang, Qiuxia; Zhao, Yali; Yuan, Gang; Liu, Ping; Zhai, Linhan; Lv, Wenzhi; Zhang, Jing

doi:10.1002/jmri.28534

Cited by 5 publications

(6 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Resting-state functional MRI is a prevalent tool in neuroimaging research, facilitating a better comprehension of cognitive impairment in individuals with TAO. Recently, there has been a growing body of research utilizing resting-state MRI techniques to explore the spontaneous brain activity in patients with TAO [8,9]. Regional homogeneity (ReHo) is a method used to assess the level of regional synchronization in time series data between a specific voxel and its nearest neighboring voxels [10].…”

Section: Introductionmentioning

confidence: 99%

Alterations in dynamic regional homogeneity within default mode network in patients with thyroid-associated ophthalmopathy

Lai,

Hu,

Huang

2024

NeuroReport

View full text Add to dashboard Cite

Thyroid-associated ophthalmopathy (TAO) is a significant autoimmune eye disease known for causing exophthalmos and substantial optic nerve damage. Prior investigations have solely focused on static functional MRI (fMRI) scans of the brain in TAO patients, neglecting the assessment of temporal variations in local brain activity. This study aimed to characterize alterations in dynamic regional homogeneity (dReHo) in TAO patients and differentiate between TAO patients and healthy controls using support vector machine (SVM) classification. Thirty-two patients with TAO and 32 healthy controls underwent resting-state fMRI scans. We calculated dReHo using sliding-window methods to evaluate changes in regional brain activity and compared these findings between the two groups. Subsequently, we employed SVM, a machine learning algorithm, to investigate the potential use of dReHo maps as diagnostic markers for TAO. Compared to healthy controls, individuals with active TAO demonstrated significantly higher dReHo values in the right angular gyrus, left precuneus, right inferior parietal as well as the left superior parietal gyrus. The SVM model demonstrated an accuracy ranging from 65.62 to 68.75% in distinguishing between TAO patients and healthy controls based on dReHo variability in these identified brain regions, with an area under the curve of 0.70 to 0.76. TAO patients showed increased dReHo in default mode network-related brain regions. The accuracy of classifying TAO patients and healthy controls based on dReHo was notably high. These results offer new insights for investigating the pathogenesis and clinical diagnostic classification of individuals with TAO.

show abstract

Section: Introductionmentioning

confidence: 99%

Alterations in dynamic regional homogeneity within default mode network in patients with thyroid-associated ophthalmopathy

Lai,

Hu,

Huang

2024

NeuroReport

View full text Add to dashboard Cite

show abstract

“…The diplopia of TED is related to inflammation or fibrosis of the orbital contents, especially the extraocular muscle [5]. TED threatens vision, especially in dysthyroid optic neuropathy and exposure keratopathy [6]. TED imposes psychological and economic burdens on patients and affects their quality of life [7].…”

Section: Introductionmentioning

confidence: 99%

Ocular Surface Changes in Treatment-Naive Thyroid Eye Disease

Liao

Lai

Aljufairi

et al. 2023

JCM

View full text Add to dashboard Cite

Objective: To investigate the association of meibomian gland dysfunction (MGD) and ocular surface exposure with tear film instability in untreated thyroid eye disease (TED) patients. Methods: A cross-sectional study of TED patients from September 2020 to September 2022 was conducted. Ocular surface parameters included ocular surface disease index (OSDI), tear meniscus height (TMH), non-invasive tear break-up time (NITBUT), partial blinking rate, lipid layer thickness (LLT), meibomian gland dropout (meiboscore), Schirmer’s test, and corneal punctate epithelial erosions (PEE). Ocular surface exposure was assessed by the margin reflex distances of the upper and lower eyelid (MRD1 and MRD2), the amount of exophthalmos, lateral flare, and lagophthalmos. Results: In total, 152 eyes from 76 TED patients (64 females and 12 males, age 42.99 ± 12.28 years) and 93 eyes from 61 healthy controls (51 females and 10 males, age 43.52 ± 17.93 years) were examined. Compared with control eyes, TED eyes had higher OSDI, TMH, LLT, and PEE; shorter NITBUT; and worse meiboscore (all p < 0.05). They also had larger amounts of exophthalmos, longer MRD1, more lateral flare, and lagophthalmos. Multivariate analysis identified an association of the tear film instability with lagophthalmos (β = −1.13, 95%CI: −2.08, −0.18) and severe MGD in the lower eyelid (β = −5.01, 95%CI = −7.59, −2.43). Conclusions: Dry eye in TED is mainly manifested as evaporative dry eye disease. Severe lower eyelid MGD and worse lagophthalmos were significantly associated with tear film instability in treatment-naive TED patients.

show abstract

“…In this issue of JMRI, Zhang et al further examined the morphological and functional brain alterations in DON using resting‐state functional MRI (rs‐fMRI) 7 . This method is widely used in neuroimaging studies to assess brain alterations in healthy and clinical populations 8–10 .…”

mentioning

confidence: 99%

“…Thus, the authors recommend future research to combine structural covariance network and functional brain network analysis to provide a deeper understanding of structural and functional brain alterations in DON. Despite these caveats, the publication by Zhang et al advances our knowledge about brain alterations in DON patients 7 …”

mentioning

confidence: 99%

See 1 more Smart Citation

Editorial for “Functional and Morphological Brain Alterations in Dysthyroid Optic Neuropathy: A Combined Resting‐State fMRI and Voxel‐Based Morphometry Study”

Othman

2022

Magnetic Resonance Imaging

View full text Add to dashboard Cite

T hyroid eye disease (TED) is an inflammation of the orbit due to the loss of immune tolerance in the thyroid gland. 1 One of the complications of TED is dysthyroid optic neuropathy (DON)-a serious impairment of optic nerve function. 2 The most prominent clinical features of DON include profound loss in visual acuity, color vision deficiency, relative afferent pupillary defect, and fluid buildup in the optic disc. 3 A person with the disease may also complain of irritated eyes and pain with eye movements. If the disease is not treated timely, patients may experience progressive vision loss that may eventually lead to permanent blindness. Consideration of the pathological mechanism of DON has important implications for the treatment of the disease. Controversy still exists regarding the pathogenesis of DON as it appears to be multifactorial. 4 Recent neuroimaging studies reported alterations of the brain structure and function in regions associated with vision in DON patients. 5,6 Therefore, current evidence suggests that patients with DON may demonstrate neural alterations in the visual pathway of DON. However, the exact structural and functional brain network alterations in DON remain elusive.In this issue of JMRI, Zhang et al further examined the morphological and functional brain alterations in DON using resting-state functional MRI (rs-fMRI). 7 This method is widely used in neuroimaging studies to assess brain alterations in healthy and clinical populations. [8][9][10] To investigate the distinct brain alterations associated with DON, the authors acquired and compared functional volumes of 30 patients with DON, 40 patients with thyroid-associated ophthalmopathy (TAO) but without DON, and 21 healthy controls. It was hypothesized that 1) the DON patients would demonstrate structural and functional alterations in brain regions associated with vision, and 2) these alterations would correlate positively with the severity of the

show abstract

Functional and Morphological Brain Alterations in Dysthyroid Optic Neuropathy: A Combined Resting‐State fMRI and Voxel‐Based Morphometry Study

Cited by 5 publications

References 40 publications

Alterations in dynamic regional homogeneity within default mode network in patients with thyroid-associated ophthalmopathy

Alterations in dynamic regional homogeneity within default mode network in patients with thyroid-associated ophthalmopathy

Ocular Surface Changes in Treatment-Naive Thyroid Eye Disease

Editorial for “Functional and Morphological Brain Alterations in Dysthyroid Optic Neuropathy: A Combined Resting‐State fMRI and Voxel‐Based Morphometry Study”

Contact Info

Product

Resources

About