Functional and molecular MRI of the bone marrow in multiple myeloma

Koutoulidis, Vassilis; Papanikolaou, Nikolaos; Moulopoulos, Lia A.

doi:10.1259/bjr.20170389

Cited by 30 publications

(25 citation statements)

References 83 publications

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“…ADC measurements can be affected by the choice of b-value as well as by technical factors, including the imaging parameters. There is currently no established b-value for the evaluation of BM characteristics, including for MM [ 22 ] . Newer diffusion methods such as the intravoxel incoherent motion-MRI, in comparison with the pathological findings, might play a role in quantifying marrow lesions.…”

Section: Discussionmentioning

confidence: 99%

Does chemical shift imaging offer a biomarker for the diagnosis and assessment of disease severity in multiple myeloma?

et al. 2021

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To investigate whether chemical shift imaging (CSI) is useful for differentiating myelomatous infiltration from hematopoietic bone marrow (BM) and for quantitatively assessing disease severity. In this retrospective study, spinal MRI, including a sagittal iterative decomposition of water and fat with echo asymmetry and least-squares estimation T2 fast spin-echo sequence, was performed on 76 myeloma patients (45 men, 67.0 ± 11.4 years; 31 women, 66.5 ± 11.0 years) and 30 control subjects (20 men, 67.0 ± 8.4 years; 10 women, 67.0 ± 9.2 years). The fat-signal fraction (FF) and mean signal dropout ratio (DR) were calculated from lumbar BM that contained no focal lesions. The BM plasma cell percentage (BMPC%) and serological data were obtained. As DR is highest when FF = 50%, the patients were divided into 2 groups: a water-dominant group (FF < 50%) and a fat-dominant group (FF > 50%). Serum monoclonal protein (M protein), β2-microglobulin, and BMPC% were significantly higher in the water-dominant group than in the fat-dominant group. In the water-dominant group, DR correlated significantly with BMPC% and M protein, whereas in the control group, DR showed a weak correlation with age but no correlation with other clinical factors. No significant differences in any clinical data were seen between high and low DR. CSI proved ineffective for differentiating myelomatous infiltration from hematopoietic BM. For myeloma patients with relatively high BM cellularity, a small signal drop on opposed-phase images indicated a higher tumor burden. For BM with relatively low cellularity, disease severity was not reflected by CSI.

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Section: Discussionmentioning

confidence: 99%

Does chemical shift imaging offer a biomarker for the diagnosis and assessment of disease severity in multiple myeloma?

et al. 2021

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“…Because the vertebral bone marrow is the main hematopoietic tissue that is usually involved in hematological diseases, changes in the tissue relaxation time of the bone marrow sometimes are more sensitive than the blood test. Such changes can be used for early diagnosis, evaluation of therapeutic efficacy, and follow-up observation after bone marrow transplantation (35,37). Another potential benefit of synthetic MRI is the ability to simultaneously generate additional types of morphologic images, such as double inversion recovery (DIR) and T1W phase-sensitive inversion recovery (PSIR) images, which have been suggested for detecting the lesions of the multiple sclerosis and related inflammatory diseases in the spine (38,39).…”

Section: Discussionmentioning

confidence: 99%

Synthetic MRI of the lumbar spine at 3.0 T: feasibility and image quality comparison with conventional MRI

Zhang

Zhu

et al. 2019

Acta Radiol

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Background Synthetic magnetic resonance imaging (MRI), which can generate multiple morphologic MR images as well as quantitative maps from a single sequence, is not widely used in the spine at 3.0 T. Purpose To investigate the feasibility of synthetic MRI of the lumbar spine in clinical practice at 3.0 T. Material and Methods Eighty-four patients with lumbar diseases underwent conventional T1-weighted images, T2-weighted images, short-tau inversion recovery (STIR) images, and synthetic MRI of the lumbar spine at 3.0 T. The quantitative and qualitative image quality and agreement for detection of spinal lesions between conventional and synthetic MRI were compared by two radiologists. Results The signal-to-noise ratios of synthetic MRI showed an inferior image quality in the vertebrae and disc, whereas were higher for spinal canal and fat on the synthetic T1-weighted, T2-weighted, and STIR images. The contrast-to-noise ratios of the synthetic MRI was superior to conventional sequences, except for the vertebrae–disc contrast-to-noise ratio on T1-weighted imaging ( P = 0.005). Image quality assessments showed that synthetic MRI had greater STIR fat suppression ( P < 0.001) and fluid brightness ( P = 0.014), as well as higher degree of artifacts ( P < 0.001) and worse spatial resolution ( P = 0.002). The inter-method agreements for detection of spinal lesions were substantial to perfect (kappa, 0.614–0.925). Conclusion Synthetic MRI is a feasible method for lumbar spine imaging in a clinical setting at 3.0-T MR. It provides morphologic sequences with acceptable image quality, good agreement with conventional MRI for detection of spinal lesions and quantitative image maps with a slightly shorter acquisition time compared with conventional MRI.

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“…WB-DWI reflects the cellularity of the tissue and is useful in monitoring treatment-induced changes in tumor cells. 24 Elevation in ADC values is noted in patients with good treatment response even early in the treatment period (Fig. 3), and evaluation of early treatment responses could be beneficial for patients that might require adjustments to their treatment plans.…”

Section: Multiple Myelomamentioning

confidence: 98%

“…23 Diffuse infiltration, in particular, has been shown to have an adverse prognosis compared to other patterns. 24 Currently, IMWG guidelines do not include the diffuse infiltration pattern as a diagnostic criterion for multiple myeloma because imaging interpretation thereof is difficult and a consensus has not yet been reached. WB-DWI can, however, provide an additional advantage in the detection of diffuse marrow infiltration, focal lesions, and extra-osseous disease.…”

Section: Multiple Myelomamentioning

confidence: 99%

Advances in whole body MRI for musculoskeletal imaging: Diffusion-weighted imaging

Lee

Park

Kim

et al. 2019

Journal of Clinical Orthopaedics and Trauma

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Recent advances in imaging technology have enabled the acquisition of anatomical and functional imaging from head to toe in a reasonably short scan time. Accordingly, whole body magnetic resonance imaging (WB-MRI) and diffusion-weighted imaging (WB-DWI) have gained recent attention for the management of musculoskeletal problems such as bone tumors and rheumatologic diseases. WB-MRI is especially useful in diagnosing systemic or widespread disease requiring whole body evaluation, such as bone metastases, multiple myeloma, lymphoma, neurofibromatosis, and spondyloarthropathies. Among WB-MRI sequences, the WB-DWI technique greatly increases the value of WB-MRI in the evaluation of disease extent and characterization as well as treatment monitoring. In support of the utilization of WB-MRI and WB-DWI in orthopedic clinics for various musculoskeletal diseases, we provide an overview of the technical aspects of WB-MRI and WB-DWI and their clinical applications in musculoskeletal tumors and rheumatic diseases.

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Functional and molecular MRI of the bone marrow in multiple myeloma

Cited by 30 publications

References 83 publications

Does chemical shift imaging offer a biomarker for the diagnosis and assessment of disease severity in multiple myeloma?

Does chemical shift imaging offer a biomarker for the diagnosis and assessment of disease severity in multiple myeloma?

Synthetic MRI of the lumbar spine at 3.0 T: feasibility and image quality comparison with conventional MRI

Advances in whole body MRI for musculoskeletal imaging: Diffusion-weighted imaging

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