Functional and Metabolic Effects of Total and Selective Vagotomy

Williams, Evan J.; Irvine, W. T.

doi:10.1016/s0140-6736(66)91006-3

Cited by 52 publications

(22 citation statements)

References 25 publications

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“…Although a few contrary opinions [22,35,36] exist, this study confirms the previous findings [3,[5][6][7]37] that the GB volume increases after vagotomy or gastrec tomy with [3,5] or without [6,7,37] an impaired GB motor function. The increased GB area we observed around 1 month after surgery persisted henceforth, whereas the impaired contractile response to caerulein returned to normality in 6 months or so.…”

Section: Discussionsupporting

confidence: 90%

Increased Risk of Gallstones following Curative Gastrectomy for Cancer

et al. 1989

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The incidence of gallstones in patients who had undergone radical gastrectomy for cure of gastric cancer was 4–8 times higher than in the general population. At least two factors seem to be involved in this high incidence: one is complete vagotomy which is inevitable in gastrectomy with lymph node dissection, and the other perioperative hepatic dysfunction. One fourth of these patients with gallstones required cholecystectomy with or without T-tube drainage. The high incidence of gallstones and a rather difficult cholecystectomy we experienced forced us to perform prophylactic cholecystectomy in these gastric cancer patients diagnosed with: cirrhosis or hepatitis; hemophilia or other hematologic disorders, and the cancer lesion involving the aborad part of the stomach.

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Section: Discussionsupporting

confidence: 90%

Increased Risk of Gallstones following Curative Gastrectomy for Cancer

et al. 1989

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“…In addition to our three patients who were incorrectly thought to have postvagotom y diarrhea, other in vestigators [20] have dem onstrated lactose m alabsorption in three out of eight patients having chronic diarrhea following vagotom y and a drainage procedure. …”

Section: Postvagotomy Diarrheamentioning

confidence: 63%

“…[20] 32 10 Drube el al. [2] 20 0 Gudmand-Heyer and Jarnum [9] 95 7 ■ One Negro with lactase deficiency excluded.…”

Section: Incidence Of Lactose Malabsorptionmentioning

confidence: 99%

Lactose Malabsorption after Gastric Surgery

Gudmand-Høyer¹

1969

Digestion

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“…However, normal contraction of the gall-bladder has also been reported following vagotomy (Clave and Caspar, 1969;Parkin et al, 1973) and function has also been considered to be normal (Williams and Irvine, 1966;Glanville and Duthie, 1964;Beneventano et al, 1969).…”

Section: Discussionmentioning

confidence: 99%

The Influence of Vagotomy on Bile Kinetics in the Rhesus Monkey

McMaster¹,

Medd²,

McLeish³

1979

Eur Surg Res

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An increased incidence of gallstones has been reported following truncal vagotomy and gastric drainage but never conclusively proven. In the Rhesus monkey, bile composition and flow is similar to man. A model of biliary drainage was established which permits continuous monitoring of bile kinetics. Following truncal vagotomy and pyloroplasty, a significant fall in bile acid concentration was observed, accompanied by a rise in cholesterol concentration. This resulted in an overall rise in cholesterol saturation. Similar changes in hepatic bile composition were, however, also seen following pyloroplasty alone, and suggests that the vagotomy itself may not be the important factor in producing bile changes.

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Functional and Metabolic Effects of Total and Selective Vagotomy

Cited by 52 publications

References 25 publications

Increased Risk of Gallstones following Curative Gastrectomy for Cancer

Increased Risk of Gallstones following Curative Gastrectomy for Cancer

Lactose Malabsorption after Gastric Surgery

The Influence of Vagotomy on Bile Kinetics in the Rhesus Monkey

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