Functional and histopathological correlations after microembolism of the peripheral labyrinthine artery in the dog.

Igarashi, Makoto; Alford, Bobby R.; Konishi, S.; Shaver, Edward F.; Guilford, Frederick R.

doi:10.1288/00005537-196904000-00005

Cited by 47 publications

(16 citation statements)

References 12 publications

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“…Total obstruction of the arterial blood supply to the coch lea causes destruction of the membranous labyrinth fol lowed by fibrous tissue proliferation and ossification [16,17], In several animal experiments microembolization of cochlear arteries was followed by fibrosis and ossification of cochlear structures [18,19], However, no fibrous or osseous proliferation was demonstrated in the temporal bones of 12 ISSHL cases [15].…”

Section: Discussionmentioning

confidence: 99%

Three-Dimensional Magnetic Resonance Imaging of the Inner Ear in Idiopathic Sudden Sensorineural Hearing Loss

Albers¹,

Demuynck

1994

ORL

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Five patients with idiopathic sudden sensorineural hearing loss (ISSHL) were examined by a combination of high-resolution computed tomography and special magnetic resonance imaging techniques. By three-dimensional constructive interference in steady state magnetic resonance imaging excellent visualization of the membranous labyrinth was obtained. No fibrous or osseous obliteration of the intralabyrinthine fluid spaces was observed in all investigated temporal bones. The results provide further evidence for a viral pathogenesis of ISSHL.

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Section: Discussionmentioning

confidence: 99%

Three-Dimensional Magnetic Resonance Imaging of the Inner Ear in Idiopathic Sudden Sensorineural Hearing Loss

Albers¹,

Demuynck

1994

ORL

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“…Blood is supplied by the labyrinthic artery, a branch of anterior inferior cerebellar artery, which thus provides oxygenation to the cochlea and the vestibular system [Igarashi et al, 1969;Alford et al, 1965;Perlman and Kumura, 1957;Gussen, 1976;Jaffe, 1975]. It is an end-functional system.…”

mentioning

confidence: 99%

Is There an Overlap between Sudden Neurosensorial Hearing Loss and Cardiovascular Risk Factors?

et al. 2008

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Introduction: Sudden sensorineural hearing loss (SSHL) has been proposed as a symptom of underlying vascular problems. The purpose of this work is to evaluate the genetic and acquired risk factors. Methods: Ninety-nine patients were tested for the presence of common polymorphisms related to thrombophilia (prothrombin and factor V Leiden) in order to assess genetic risk factors, and several parameters classically associated with vascular disorders (cardiovascular events, brain stroke and antiphospholipid syndrome) were evaluated. Additional assessments of personal and familial history risk factors for vascular disorders were performed in each patient. Results: Thrombophilia studies did not demonstrate statistically relevant differences between the patients and control group. However, lipidemia profile and directed personal and familial histories showed positive trends for SSHL. Conclusion: The lack of clear relationships between SSHL and other vascular risk factors suggests multicausality as a predominant disease profile. Although preliminary results point at a vascular involvement in SSHL, a long-term prospective study is necessary to demonstrate that SSHL represents an early vascular symptom.

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“…For example, Schucknecht and Donovan [59] did not find any disruption of the windows or histological changes in Reissner's membrane or in the basilar membrane of the cochlear duct in sudden deafness patients. Fibrosis and ossification of the cochlea have been reported to be typical temporal bone findings in experimental animals with sudden deafness due to a vascular etiology [65,66]. However, similar changes have not been found in humans, neither in histopathological nor in radiological studies [59,61,67].…”

Section: Sudden Deafness and Viral Infectionsmentioning

confidence: 94%

Sudden Deafness and Viral Infections

Pitkäranta

Vasama

Julkunen

1999

Otorhinolaryngol Nova

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Sudden deafness is a dramatic and relatively common otological problem. The etiology in most cases remains unresolved although virus involvement has strong support. Sudden deafness has been associated with mumps, rubella, the respiratory and herpes groups of viruses as well as other more rare ones like hantavirus and Lassa virus. Perhaps the bestknown example of virus-induced sudden deafness is acute unilateral hearing loss associated with mumps virus infection. Mumps virus has also been isolated from the inner ear suggesting a direct virus-induced cytolytic mechanism for deafness. Herpesviruses are neurotropic and they have a tendency to become chronic. Therefore they have been strong candidates for viruses being responsible for acute hearing loss. Although serological associations have been found in certain studies, convincing evidence for the involvement of herpes and varicella-zoster viruses as agents causing direct cochlear damage and hearing loss in humans is missing. A number of case reports have associated sudden deafness to rubella, adeno- and hantavirus infections. Multiple studies showing no association of viruses with sudden deafness may reflect seasonal, geographical or epidemiological differences in this disease. This may also bring up the possibility of other etiological factors such as general inflammatory or autoimmune mechanisms for the disease. Histopathological changes in the affected ears are characterized by abnormal cellular architecture in the inner ear with loss of apical and spiral ganglion cells and destruction of the organ of Corti. Similar histopathological changes have been found in experimental animal models infected with mumps, rubella or herpesviruses. Histopathological observations could favor the theory of viral etiology in idiopathic sudden deafness but do not rule out the possibility of immunological disturbances, which would lead to similar histopathological changes.

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Functional and histopathological correlations after microembolism of the peripheral labyrinthine artery in the dog.

Cited by 47 publications

References 12 publications

Three-Dimensional Magnetic Resonance Imaging of the Inner Ear in Idiopathic Sudden Sensorineural Hearing Loss

Three-Dimensional Magnetic Resonance Imaging of the Inner Ear in Idiopathic Sudden Sensorineural Hearing Loss

Is There an Overlap between Sudden Neurosensorial Hearing Loss and Cardiovascular Risk Factors?

Sudden Deafness and Viral Infections

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