Functional and effective connectivity of anterior insula in anorexia nervosa and bulimia nervosa

Abnormal functional global and local brain connectivity in female patients with anorexia nervosa

“…†Each node is listed with its name, location on left (L) or right (R) hemisphere and an ID number. and colleagues 16 found RSFC between the dorsal anterior cin gulate cortex and DLPFC in medicated adults with anorexia nervosa. However, the aforementioned studies also found in creases of RSFC in patients with anorexia nervosa, and an other study in patients recovered from anorexia nervosa re ported increased default mode network connectivity.…”

“…The existing studies, which are often limited by small sample sizes, typically used independent component analysis (ICA) or seed based connectivity analysis 13 to probe specific known networks, such as the default mode, somatosensory or salience networks. [14][15][16] See Appendix 1, Table S8 (available at jpn.ca), for an overview of all known RSFC studies in pa tients with anorexia nervosa.…”

Reduced salience and default mode network activity in women with anorexia nervosa

“…1 While the neurobiologic al mechanisms underlying anorexia nervosa are not well understood, neuroimaging studies have found altered brain activation in brain regions contributing to reward and anxiety processing in individuals with anorexia nervosa. [2][3][4][5][6][7][8][9][10][11] Such alterations could be involved in the pathologic drive to eat in these individuals. 6,8 To gain a clearer understanding of neurobiological mechan isms involved in anorexia nervosa, it is important to under stand the functionality of the brain networks that underlie illness behaviour.…”

“…Cowdrey and colleagues 39 did not study currently ill women, but they found that recovered women showed increased activity within the DMN compared with controls. Kim and colleagues 10 found distinct patterns of connectivity between the insula and frontal regions of the brain among participants with anorexia nervosa, bulimia nervosa and control participants across a visual food cue task. In addition, Amianto and colleagues 40 recently found alterations in connectivity patterns within the cerebellum in participants with anorexia nervosa and bulimia nervosa compared with controls.…”

Psychological risk factors, cognitive-contextual approaches and neural correlates in eating disorders: an integrative review

“…A study comparing AN, BN and controls revealed that effective connectivity patterns between the insula and frontal regions distinguished groups while performing a visual food cue task [24]. Furthermore, other studies, using effective connectivity analyses, revealed different networks between AN and healthy controls during visual processing of human bodies, suggesting alterations in the networks that perform body processing in women with AN [23].…”