Functional and effective connectivity in EEG alpha and beta bands during intermittent flash stimulation in migraine with and without aura

Tommaso, Marina de; Stramaglia, Sebastiano; Marinazzo, Daniele; Trotta, Gabriele; Pellicoro, M.

doi:10.1177/0333102413477741

Cited by 56 publications

(68 citation statements)

References 44 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a preliminary study, individuals who had migraine without aura showed increased phase synchronization in the alpha band and reduced connectivity during intermittent flash stimula tion, whereas those who had migraine with aura dis played clear desynchro nization in the beta frequency range and increased connectivity during visual stimula tion ( Figure 1). 25 Given that brain activation is now described in terms of increased connectivity of different functional brain networks, visual stimulation seems to induce a more vigorous cortical activation and spread of information in migraine with aura than in migraine without aura (which is charac terized by weak interaction between cortical regions), possibly because of a prevalent resonance of rhythmic activity generated at subcortical and thalamic levels. 22 Evoked responses to non-noxious stimuli…”

Section: Increased Synchronizationmentioning

confidence: 99%

“…This phenomenon might be subtended by increased cortical activation in migraine with aura during visual stimulation. The figure is based on data from a study by de Tommaso et al 25 effect on habituation profiles. 66,67 Finally, spontaneous clinical worsening or improvement of attack frequency can influence the baseline level of thalamocortical activa tion 68,69 and, hence, the degree of habituation in patients with migraine.…”

Section: Impaired Habituationmentioning

confidence: 99%

“…The results have provided three main sets of observations, which were consistent across most studies. First, between attacks, a stimulus frequency dependent increase occurs in photic driving and synchronization of EEG alpha (8-13 Hz) and beta (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) rhythms. Second, the interictal migrain ous brain is characterized by a habituation (or adapta tion) deficit of cortical evoked responses to repetitive, non noxious sensory stimuli-this deficit normalizes during an attack.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Altered processing of sensory stimuli in patients with migraine

et al. 2014

Self Cite

View full text Add to dashboard Cite

| Migraine is a cyclic disorder, in which functional and morphological brain changes fluctuate over time, culminating periodically in an attack. In the migrainous brain, temporal processing of external stimuli and sequential recruitment of neuronal networks are often dysfunctional. These changes reflect complex CNS dysfunction patterns. Assessment of multimodal evoked potentials and nociceptive reflex responses can reveal altered patterns of the brain's electrophysiological activity, thereby aiding our understanding of the pathophysiology of migraine. In this Review, we summarize the most important findings on temporal processing of evoked and reflex responses in migraine. Considering these data, we propose that thalamocortical dysrhythmia may be responsible for the altered synchronicity in migraine. To test this hypothesis in future research, electrophysiological recordings should be combined with neuroimaging studies so that the temporal patterns of sensory processing in patients with migraine can be correlated with the accompanying anatomical and functional changes.

show abstract

Section: Increased Synchronizationmentioning

confidence: 99%

Section: Impaired Habituationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Altered processing of sensory stimuli in patients with migraine

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…In a recent study [14] we observed increased causal connections across 6 scalp derivations in beta band in MWA patients compared with both MWoA and controls under intermittent flash stimulation, suggesting a different pattern of visual stimuli processing and cortical activation modality in patients experiencing aura symptoms. A recent FMRI study confirmed a spread of cortical activation in MWA patients during a visual task [15].…”

Section: Introductionmentioning

confidence: 72%

Effective connectivity and cortical information flow under visual stimulation in migraine with aura

Trotta

Stramaglia

Pellicoro

et al. 2013

5th IEEE International Workshop on Advances in Sensors and Interfaces IWASI

Self Cite

View full text Add to dashboard Cite

The study aims to evaluate effective connectivity patterns in EEG rhythms under repetitive visual stimulation in migraine with aura patients, in terms of non linear Granger causality and Transfer Entropy. Fifteen migraine with aura (MWA) and 15 migraine without aura (MWoA) patients were evaluated interictally. All subjects were submitted to high density (65 channels) EEG during visual stimulation by black and white checkerboard gratings with two spatial frequencies (0.5 and 2.0 cpd) at 5 and 10Hz (10 and 20 reversal/s). The same visual stimulation was employed to evaluate BOLD signal changes in 6 MWA and 6 MWoA. MWA patients showed increased non linear Granger causality values in beta band under all types of visual stimulation, and increased information flow toward frontal regions, with respect to MWoA and controls. Our results outline important pathophysiological difference between migraine phenotypes. An increased capacity in cortical connections and transfer information may subtend the perception of aura symptoms, probably favoring the progression of cortical spreading depression. © 2013 IEEE

show abstract

“…Besides overt classification differences between migraine with (MA) and without aura (MO) (International Headache Society, 2004), few neurophysiological studies have compared these two entities (Coppola et al, 2007;de Tommaso et al, 2013). When considered both together, the most consistent finding was a defective habituation of pattern reversal-visual evoked potentials (PR-VEPs) (Schoenen, 2006).…”

Section: Introductionmentioning

confidence: 99%