Functional and Dysfunctional Synaptic Plasticity in Prefrontal Cortex: Roles in Psychiatric Disorders

Goto, Yukiori; Yang, Charles R.; Otani, Satoru

doi:10.1016/j.biopsych.2009.08.026

Cited by 269 publications

(199 citation statements)

References 90 publications

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“…The frontal lobe, especially the prefrontal cortex (PFC) plays an essential role in various high‐level cognitive functions, such as executive functions (Mansouri, Tanaka, & Buckley, 2009; Miller, 2000; Miller & Cohen, 2001), reasoning and planning (Wood & Grafman, 2003), decision making (Wallis, 2007), social cognition, and moral judgment (Forbes & Grafman, 2010). Meanwhile, the deficits in PFC functions are involved in the pathophysiology of several psychiatric and neurological disorders such as schizophrenia, drug addiction, mood disorders, and Alzheimer's disease (Fuster, 2001; Goto, Yang, & Otani, 2010). Therefore, inspecting the PFC's organizing patterns is not only crucial for us to elucidate the complex neural mechanism of high‐level cognitive functions or brain disorders, but also absolutely necessary to pave a way for new treatments.…”

Section: Introductionmentioning

confidence: 99%

Neuroticism and conscientiousness respectively positively and negatively correlated with the network characteristic path length in dorsal lateral prefrontal cortex: A resting‐state fNIRS study

Wang

Zhang

et al. 2018

Brain and Behavior

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BackgroundAccumulating evidence shows that the dorsal lateral prefrontal cortex (dlPFC) is implicated in personality traits. In this study, resting‐state functional near infrared spectroscopy (fNIRS) combined with small‐world analysis was utilized to examine the relationship between the network properties of dlPFC and personality traits.MethodsThirty college students (aged between 20 and 29) were recruited from the University of Macau campus, whose personality scores were accessed with the NEO‐FFT questionnaire. Graph theory combined with resting‐state fNIRS data was used to quantify the network properties of dlPFC, whereas Pearson correlation analysis was performed to generate the relationship between the small‐world indicators and personality scores.ResultsCompared to matched random networks, the resting‐state brain networks exhibited a larger clustering coefficient (C p, 0.1–0.66), shorter characteristic path length (L p, 0.1–0.66), and higher global (E g, 0.1–0.66) and local efficiency (E loc, 0.1–0.65). In particular, conscientiousness (r = −0.63) and neuroticism (r = 0.40) respectively showed negative and positive correlation with the L p.ConclusionsThe resting‐state functional brain networks in dlPFC exhibited the small‐world properties. In addition, participants with higher conscientiousness scores showed a shorter L p.

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Section: Introductionmentioning

confidence: 99%

Neuroticism and conscientiousness respectively positively and negatively correlated with the network characteristic path length in dorsal lateral prefrontal cortex: A resting‐state fNIRS study

Wang

Zhang

et al. 2018

Brain and Behavior

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show abstract

“…The prefrontal cortex is a compartment of the human brain involved in highly diverse processes, ranging from cognition, motivation, emotion, and complex motor activity to social interactions [1][2][3][4][5][6] . Disturbances of prefrontal functions are involved in a multitude of neuropsychiatric diseases, including depression, schizophrenia, addiction, dementia, and Parkinson´s disease [7][8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Exploring prefrontal cortex functions in healthy humans by transcranial electrical stimulation

Kuo

Nitsche²

2015

Neurosci. Bull.

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The prefrontal cortex is involved in a multitude of cognitive, emotional, motivational, and social processes, so exploring its specifi c functions is crucial for understanding human experience and behavior. Functional imaging approaches have largely contributed to the enhancement of our understanding, but might have limitations in establishing causal relationships between physiology and the related psychological and behavioral processes. Non-invasive electrical stimulation with direct or alternating currents can help to enhance our understanding with regard to specific processes, and might provide future protocols able to improve them in case of malfunctions. We review the current state of the fi eld, and provide an outlook for future developments.

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“…Repeated exposure to severe stress in critical developmental stages, especially during the early childhood, may disrupt PFC development and impair working memory later in life (Evans and Schamberg, 2009;Hanson et al, 2012). Accumulating evidence demonstrates that early-life stress is one of the major risk factors for psychiatric disorders, including schizophrenia, depression, and anxiety disorders (Bradley et al, 2008;Cutajar et al, 2010;Nugent et al, 2011) that are associated with prefrontal dysfunction (Goto et al, 2010) and structural abnormalities (Black et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Stress during a Critical Postnatal Period Induces Region-Specific Structural Abnormalities and Dysfunction of the Prefrontal Cortex via CRF1

Yang

Liao

Uribe-Mariño

et al. 2014

Neuropsychopharmacol

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During the early postnatal period, environmental influences play a pivotal role in shaping the development of the neocortex, including the prefrontal cortex (PFC) that is crucial for working memory and goal-directed actions. Exposure to stressful experiences during this critical period may disrupt the development of PFC pyramidal neurons and impair the wiring and function of related neural circuits. However, the molecular mechanisms of the impact of early-life stress on PFC development and function are not well understood. In this study, we found that repeated stress exposure during the first postnatal week hampered dendritic development in layers II/III and V pyramidal neurons in the dorsal agranular cingulate cortex (ACd) and prelimbic cortex (PL) of neonatal mice. The deleterious effects of early postnatal stress on structural plasticity persisted to adulthood only in ACd layer V pyramidal neurons. Most importantly, concurrent blockade of corticotropin-releasing factor receptor 1 (CRF 1 ) by systemic antalarmin administration (20 mg/g of body weight) during early-life stress exposure prevented stress-induced apical dendritic retraction and spine loss in ACd layer V neurons and impairments in PFC-dependent cognitive tasks. Moreover, the magnitude of dendritic regression, especially the shrinkage of apical branches, of ACd layer V neurons predicted the degree of cognitive deficits in stressed mice. Our data highlight the region-specific effects of early postnatal stress on the structural plasticity of prefrontal pyramidal neurons, and suggest a critical role of CRF 1 in modulating early-life stress-induced prefrontal abnormalities.

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Functional and Dysfunctional Synaptic Plasticity in Prefrontal Cortex: Roles in Psychiatric Disorders

Cited by 269 publications

References 90 publications

Neuroticism and conscientiousness respectively positively and negatively correlated with the network characteristic path length in dorsal lateral prefrontal cortex: A resting‐state fNIRS study

Neuroticism and conscientiousness respectively positively and negatively correlated with the network characteristic path length in dorsal lateral prefrontal cortex: A resting‐state fNIRS study

Exploring prefrontal cortex functions in healthy humans by transcranial electrical stimulation

Stress during a Critical Postnatal Period Induces Region-Specific Structural Abnormalities and Dysfunction of the Prefrontal Cortex via CRF1

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