Functional and Anatomic Recovery in the Monkey Brain following Excision of Fetal Encephalocele

Michejda, Maria; Bacher, John

doi:10.1159/000120226

Cited by 12 publications

(3 citation statements)

References 9 publications

(9 reference statements)

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“…According to Michejda [22,23], after resection of the occipital lobe of the fetal monkey brain in the surgical treatment of experimental encephalocele, covering the cranial defect with allogenic bone plate, and incubation of the fetus in utero for about 50 days followed by cesarean section, the neonatal brain showed a normal anatomical structure, and the monkey showed normal moving ability as well as preserved visual function. In the case of monkey brain resection at the neonatal stage, however, the monkey showed no anatomical recovery of the brain, and the animal became blind and lost normal moving ability.…”

Section: Possible Restoration Of Pve By Regrowth Function Of Fetal Brainmentioning

confidence: 99%

Neonatal Periventricular Leukomalacia Preceded by Fetal Periventricular Echodensity

Yamamoto¹,

Utsu²,

Serizawa³

et al. 2000

Fetal Diagn Ther

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Objective: The purpose of this prospective study is to verify whether fetal periventricular echodensity (PVE) precedes neonatal periventricular leukomalacia (PVL). Methods: Fetal brains were studied with transvaginal scan in 63 high-risk fetuses from 17 to 32 weeks of pregnancy, PVE echogenicity was quantified with ultrasonic histogram, and neonatal brains and clinical courses were studied after birth. Results: No fetal cystic PVL was found, instead, fetal PVE was detected in 42 fetuses. The quantified echogenicity value was higher in PVE than in normal brain. Four cases developed neonatal PVL among 28 preterm and 1 among 14 term births. Neonatal PVL developed in the 23 cases of persistent fetal PVE, whereas no neonatal PVL was found when fetal PVE was negative or disappeared. Cord compression signs were common in PVL cases. Conclusion: Neonatal PVL was preceded by antepartum persistent fetal PVE in the present study.

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Section: Possible Restoration Of Pve By Regrowth Function Of Fetal Brainmentioning

confidence: 99%

Neonatal Periventricular Leukomalacia Preceded by Fetal Periventricular Echodensity

Yamamoto¹,

Utsu²,

Serizawa³

et al. 2000

Fetal Diagn Ther

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“…However, during the last decade, there has been strong evi dence that the ability of the CNS for rapid growth and regeneration and cytoarchitectural reorganization is very high in fetal and neonatal periods [65][66][67][68][69]. These processes were evident in an experiment, which in volved in utero versus postnatal (4-8 weeks) amputation of a corticosteroid-induced oc cipital encephalocele associated with a crani um bifidum [70], A major portion of the brain (two thirds of the occipital lobes) which is totally occupied by the primary visual, or striate cortex was removed (Fig. 5).…”

Section: Regeneration and Regrowth Of Cns Fetal Tissuementioning

confidence: 99%

Antenatal Treatment of Central Nervous System Defects: Current and Future Developments in Experimental Therapies

Michejda¹

1989

Fetal Diagn Ther

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“…Sometimes species differences are also critical. A recent study by Michejda andBacher (1985-1986) illustrates the startling capacity of the CNS for functional recovery following extensive damage, provided conditions are appropriate. Herniation of the occipital lobes (encephalocele) of fetal monkeys was produced by administering a teratogen to the mother for three days during the first month of pregnancy.…”

Section: Precedents and Speculationmentioning

confidence: 99%

Spastic Cerebral Palsy: Possible Spinal Interneuronal Contributions

Harrison

1988

Develop Med Child Neuro

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Summary The author explores the possibility that abnormal and immature spinal interneuronal circuits play a rôle in spastic cerebral palsy. Interneuronal abnormalities could account for a number of characteristic signs: sensitivity to normally innocuous stimuli, hyperreflexia, abnormal and inappropriate co–ordination patterns, and limitations in acquiring, planning, executing and correcting skilful actions. The precise pattern of interneuronal anomalies present will depend on the original site of the lesion, age at onset, and on how central and segmental development were affected. Although the number of relevant studies is very small, there are indications that long–term training can produce changes in segmental response, both by altering descending inhibition and by producing lasting changes in spinal neuronal organisation and responsiveness. Modern recording techniques have introduced the prospect of tracing immature and abnormal segmental components and of establishing their impacts on movement control. RÉSUMÉ Infirmité motrice cérébrale spastique: possibilité d'une contribution médullaire interneurale Les auteurs envisagent la possibilité que des circuits médullaires interneuraux anormaux et immatures jouent un rôle dans la spasticité de l'IMC. Les anomalies interneurales pourraient rendre compte d'un certain nombre de signes caractéristiques: sensibilitéà des stimuli normalement inoffensifs, hyperreflexie, groupements de coordination anormaux et inappropriés, limitations dans l'acquisition, la prévision, l'execution et la correction d'actions efficaces. Le groupement précis de anomalies interneurales recontrées pourrait dépendre du site original de la lésion, de l'âge de début et de la façon dont aurait été affecté le développement central et segmentaire. Quoique le nombre d'études sur le sujet est très faible, il existe des éléments en faveur de l'efficience d'un apprentissage à long terme sur des modifications de la réponse segmentaire, à la fois en altérant les inhibitions descendantes et en produisant des changements durables de l'aptitude à répondre et de l'organisation au niveau neuronal médullaire. Les techniques d'enregistrement modernes doivent permettre de retrouver les composantes segmentaires anormales et immatures, d'établir leur impact sur le contrôle du mouvement. ZUSAMMENFASSUNG Spastische Cerebralparese: mögliche spinale interneuronale Beteiligung Der Autor untersucht die Frage, ob abnorme und unreife spinale interneuronale Verbindungen bei der spastischen Cerebralparese eine Rolle spielen. Interneuronale Anomalien könnten die Ursache für eine Reihe charakteristischer Befunde sein: Sensibilität für normalerweise harmlose Reize, Hyperreflexie, abnorme und unangepaßte Koordinationsmuster und die Einschränkungen beim Erlernen, Planen, Ausführen und Korrigieren von Geschicklichkeitsaufgaben. Das genaue Muster der vorliegenden interneuronalen Anomalien hangt ab von dem ursprünglichen Sitz der Läsion, vom Eintrittsalter und davon, wie die zentrale und segmentale Entwicklung betroffen war. Obwohl d...

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Functional and Anatomic Recovery in the Monkey Brain following Excision of Fetal Encephalocele

Cited by 12 publications

References 9 publications

Neonatal Periventricular Leukomalacia Preceded by Fetal Periventricular Echodensity

Neonatal Periventricular Leukomalacia Preceded by Fetal Periventricular Echodensity

Antenatal Treatment of Central Nervous System Defects: Current and Future Developments in Experimental Therapies

Spastic Cerebral Palsy: Possible Spinal Interneuronal Contributions

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