Functional anatomy of lymph nodes. II. Peripheral lymph‐borne mononuclear cells

Kelly, Robert L.; Balfour, Brigid M.; Armstrong, John A.; Griffith, Shannon

doi:10.1002/ar.1091900103

Cited by 147 publications

(52 citation statements)

References 26 publications

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“…William Bowers [41,42] and Don Mason and Gordon MacPherson [25,43] found active nonadherent accessory cells in thoracic duct lymph of rats, while Brigid Balfour, Hemmo Drexhage and Stella Knight [44][45][46] described similar veiled cells in the afferent lymph of rabbits and guinea pigs. These early observations on distinct cells in different tissues and species were brought together in a review in 1982, where ideas of a DC system were considered [47].…”

Section: Dendritic Cells As Antigen-presenting Cells For Autologous Tmentioning

confidence: 99%

Dendritic cells: Understanding immunogenicity

2007

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The impetus for the discovery of dendritic cells in 1972 was to understand immunogenicity, the capacity of an antigenic substance to provoke immunity. During experiments to characterize "accessory" cells that enhanced immunity, we spotted unusual stellate cells in mouse spleen. They had a distinct capacity to form and retract processes or dendrites and were named dendritic cells (DC). DC proved to be different from other cell types and to be peculiarly immunogenic when loaded with antigens. When Langerhans cells were studied, immunogenicity was found to involve two steps: antigen presentation by immature DC and maturation to elicit immunity. Antigenbearing DC were also immunogenic in vivo and were therefore termed "nature's adjuvants". Several labs then learned to generate large numbers of DC from progenitors, which accelerated DC research. Tolerogenicity via DC, including the control of foxp3 + suppressor T cells, was recently discovered. Two areas of current research that I find intriguing are to identify mechanisms for antigen uptake and processing, and for the control of different types of immunity and tolerance. These subjects should be studied in vivo with clinically relevant antigens, so that the activities of DC can be better integrated into the prevention and treatment of disease in patients.

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Section: Dendritic Cells As Antigen-presenting Cells For Autologous Tmentioning

confidence: 99%

Dendritic cells: Understanding immunogenicity

2007

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“…le;Veerman, 1974;Kaiserling & Lennert, 1974;Heusermann et al, 1974;Lampert et al, 1980). These IDR cells are related to skin Langerhans cells and circulating "veiled" cells (Kelly et al, 1978) which are also strongly Ia+ (Stingl et al, 1978;Spry et al, 1980) and may play a role in the presentation of antigens to T cells in immunogenic form (Silberberg-Sinakin et al, 1976). Another cell type which expresses Ia-like antigens is the endothelium (Hirschberg et ai., 1979).…”

mentioning

confidence: 99%

Immuno-histological diagnosis of lymphoproliferative diseases by selected combinations of antisera and monoclonal antibodies

Jánossy¹,

Thomas²,

Pizzolo³

et al. 1980

Br J Cancer

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“…The current accepted concept is that DC comprise three distinct subpopulations, including two within the myeloid lineage (LC and interstitial DC) and one within the lymphoid lineage [107]. DC can be classified on the basis of their tissue location as: interdigitating reticulum cells in the dome and inter follicular areas (IFA) of lymphoid organs [59,168]; Veiled cells (non lymphoid DC) in afferent lymph [61,138]; Blood DC when in circulation [136,166]; Langerhans cells in the epidermis [150]; dermal DC when found in the dermis of the skin [142,146]; follicular DC, in B cell areas (follicles) of the spleen, lymph nodes and Peyer's patches [128]; and interstitial DC, in the interstitial connective tissues of non-lymphoid organs [45]. Tissues from which DC have been isolated are summarized in Table 1.…”

Section: Dendritic Cell Classificationmentioning

confidence: 99%

Dendritic Cells: A Specialized Complex System of Antigen Presenting Cells.

Makala

Nagasawa

2002

The Journal of Veterinary Medical Science

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ABSTRACT. The dendritic cell (DC) network is a specialized system for presenting antigen to naive or quiescent T cells, and consequently plays a central role in the induction of T cell and B cell immunity in vivo. Despite considerable achievements in the last ten years, in our understanding of how DC induce and regulate immune responses, much remains to be learned about this complex system of cells. The history and current status of DC termed "directors of the immune system orchestra" is reviewed. The present understanding of DC cell biology, function and use, taking into account their complexity is discussed.KEY WORDS: classification, dendritic cell, feature, ontogeny.J. Vet. Med. Sci. 64(3): 181-193, 2002 Members of the dendritic cell (DC) lineage have potent immunostimulatory properties and are widely distributed throughout the body. Although the principal function of DC appear to be activation of T cells [6, 37], their diverse anatomic locations indicate that they have distinct strategies for differentiation and regulation of function [20, 48,110,122,123,173,178]. This represents a control point for the onset of immunity. Distributed as sentinels throughout the body, DC are poised to capture antigen, migrate to draining lymphoid organs and after a process of maturation, select antigen specific lymphocytes to which they present the processed antigen, thus initiating clonal immunity. Circulating precursor DC enter peripheral tissues as immature DC where they capture microbial or viral antigens. Following antigen capture the immature DC leave the tissues and migrate to lymphoid organs, where after maturation, they display antigen-derived peptides on their MHC molecules, which in turn select out rare circulating antigen-specific T cells [Reviewed in 107]. These reactive T cells become activated and further induce terminal DC maturation, which support lymphocyte expansion and differentiation [141]. Activated T cells migrate back to the injured tissue, because they can selectively transverse inflamed epithelium. Helper T cells secrete lymphokines and cytotoxic T cells eventually lyse the infected cells [6]. As DC change in phenotype during their life span and thus do not carry stable surface markers, it is difficult to pinpoint individual phenotypes clearly within the huge family of DC, or even to use certain markers for ontogenic deductions. First identified in the epidermis in 1868, and then termed Langerhans cells (LC), DC presence in other tissues was identified 28 years ago, a century later [142]. These cells are present in low numbers in several tissues and studies have been hampered by low yield following purification [86,87,130,171]. The question of whether DC originate from a separate lineage or belong to the monocyte/ macrophage family is still unresolved hitherto-in other words, the DC family tree has not yet been drawn. DENDRITIC CELL ONTOGENYAbundant evidence from studies, both in vivo and in vitro, indicates that DC in mouse spleen [149], rat lymph [111] and mouse epidermis [42,60] originate from ...

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Functional anatomy of lymph nodes. II. Peripheral lymph‐borne mononuclear cells

Cited by 147 publications

References 26 publications

Dendritic cells: Understanding immunogenicity

Dendritic cells: Understanding immunogenicity

Immuno-histological diagnosis of lymphoproliferative diseases by selected combinations of antisera and monoclonal antibodies

Dendritic Cells: A Specialized Complex System of Antigen Presenting Cells.

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