Functional anatomy of GO/NO-GO discrimination and response selection – a PET study in man

Kawashima, Ryuta; Satoh, Kazunori; Itoh, Hiroshi; Ono, Sachiko; Furumoto, Shozo; Gotoh, Raira; Koyama, Masamichi; Yoshioka, Seiro; Takahashi, Tsuneo; Takahashi, Kunihisa; Yanagisawa, Toru; Fukuda, Hiroshi

doi:10.1016/s0006-8993(96)00389-7

Cited by 111 publications

(66 citation statements)

References 48 publications

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“…, 2000). Similar findings have also been observed with other tasks that involve response incompatibilities like the flanker task (Bugg, 2008), Simon task (Kerns, 2006) and go/no‐go paradigms (Kawashima et al. , 1996; Tsujimoto et al.…”

Section: Role Of the Dorsomedial Prefrontal Cortex In Cognitive Controlsupporting

confidence: 85%

Strategic control in decision‐making under uncertainty

Venkatraman

Huettel

2012

Eur J of Neuroscience

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Complex economic decisions – whether investing money for retirement or purchasing some new electronic gadget – often involve uncertainty about the likely consequences of our choices. Critical for resolving that uncertainty are strategic meta-decision processes, which allow people to simplify complex decision problems, to evaluate outcomes against a variety of contexts, and to flexibly match behavior to changes in the environment. In recent years, substantial research implicates the dorsomedial prefrontal cortex (dmPFC) in the flexible control of behavior. However, nearly all such evidence comes from paradigms involving executive function or response selection, not complex decision making. Here, we review evidence that demonstrates that the dmPFC contributes to strategic control in complex decision making. This region contains a functional topography such that the posterior dmPFC supports response-related control while the anterior dmPFC supports strategic control. Activation in the anterior dmPFC signals changes in how a decision problem is represented, which in turn can shape computational processes elsewhere in the brain. Based on these findings, we argue both for generalized contributions of the dmPFC to cognitive control, and for specific computational roles for its subregions depending upon the task demands and context. We also contend that these strategic considerations are also likely to be critical for decision making in other domains, including interpersonal interactions in social settings.

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Section: Role Of the Dorsomedial Prefrontal Cortex In Cognitive Controlsupporting

confidence: 85%

Strategic control in decision‐making under uncertainty

Venkatraman

Huettel

2012

Eur J of Neuroscience

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“…However, in the neuroimaging paradigms used to study SA, where the urge to act conflicts with the instruction to withhold any overt behavior, there must be control mechanisms at least as powerful as the motivational processes. Activation in the caudal ACC was found in a study of a GO/NO-GO task (Kawashima et al, 1996). More generally, it is activated when there is conflict between possible responses (Carter and van Veen, 2007).…”

Section: The Relation Between the Freudian Theory Of Drives And The Nmentioning

confidence: 92%

Reading the Freudian theory of sexual drives from a functional neuroimaging perspective

Stoléru

2014

Front. Hum. Neurosci.

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One of the essential tasks of neuropsychoanalysis is to investigate the neural correlates of sexual drives. Here, we consider the four defining characteristics of sexual drives as delineated by Freud: their pressure, aim, object, and source. We systematically examine the relations between these characteristics and the four-component neurophenomenological model that we have proposed based on functional neuroimaging studies, which comprises a cognitive, a motivational, an emotional and an autonomic/neuroendocrine component. Functional neuroimaging studies of sexual arousal (SA) have thrown a new light on the four fundamental characteristics of sexual drives by identifying their potential neural correlates. While these studies are essentially consistent with the Freudian model of drives, the main difference emerging between the functional neuroimaging perspective on sexual drives and the Freudian theory relates to the source of drives. From a functional neuroimaging perspective, sources of sexual drives, conceived by psychoanalysis as processes of excitation occurring in a peripheral organ, do not seem, at least in adult subjects, to be an essential part of the determinants of SA. It is rather the central processing of visual or genital stimuli that gives to these stimuli their sexually arousing and sexually pleasurable character. Finally, based on functional neuroimaging results, some possible improvements to the psychoanalytic theory of sexual drives are suggested.

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“…Whether it involves stopping at a red light or not spending beyond one's means, inhibition is an important function for daily life. Several studies with healthy volunteers have identified critical neural substrates of inhibition during go no‐go performance, which include the inferior and middle frontal cortices [58,90–96], inferior parietal lobe [90–92,95,97,98], anterior cingulate [99,100], precuneus [91,92,95,98], insula [59,91,97,101] and superior temporal gyrus [91,95].…”

Section: Summary Of Findings Organized By Cognitive/affective Processesmentioning

confidence: 99%

Location, location: using functional magnetic resonance imaging to pinpoint brain differences relevant to stimulant use

Aron¹,

Paulus

2007

Addiction

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AimsThe purpose of this review is to summarize the neural substrate dysfunctions and disrupted cognitive, affective and experiential processes observed in methamphetamine and cocaine-dependent individuals. Methods We reviewed all publications in PubMed that conducted comparison studies between healthy volunteers and cocaine-, amphetamine-or methamphetamine-dependent individuals using functional magnetic resonance imaging. Results Stimulant dependence is characterized by a distributed alteration of functional activation to a number of experimental paradigms. Attenuated anterior and posterior cingulate activation, reduced inferior frontal and dorsolateral prefrontal cortex activation and altered posterior parietal activation point towards an inadequate demand-specific processing of information. Processes reported most consistently to be deficient in these functional neuroimaging studies include inhibitory control, executive functioning and decision-making. Conclusion One emerging theme is that stimulantdependent individuals show specific, rather than generic, brain activation differences, i.e. instead of showing more or less brain activation regardless of task, they exhibit process-related brain activation differences that are consistent with a shift from context-specific, effortful processing to more stereotyped, habitual response generation.

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Functional anatomy of GO/NO-GO discrimination and response selection – a PET study in man

Cited by 111 publications

References 48 publications

Strategic control in decision‐making under uncertainty

Strategic control in decision‐making under uncertainty

Reading the Freudian theory of sexual drives from a functional neuroimaging perspective

Location, location: using functional magnetic resonance imaging to pinpoint brain differences relevant to stimulant use

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