Functional Anatomy and Histology of the Testis

Fietz, Daniela; Bergmann, Martin

doi:10.1007/978-3-319-29456-8_9-1

Cited by 12 publications

(1 citation statement)

References 63 publications

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“…SCs are responsible for supporting the regulation of the spermatogenesis process [3] and the supply of nutrients to germ cells [1]. LCs, on the other hand, are in charge of the synthesis and secretion of androgens, necessary for the masculinization of male fetuses, together with the initiation and maintenance of spermatogenesis [4,5]. In addition, LCs produce proteins with endogenous and xenotoxic metabolic functions, which also reduce oxidative stress, which thus protects the testicle from toxins [6,7].…”

Section: Introductionmentioning

confidence: 99%

The Fate of Leydig Cells in Men with Spermatogenic Failure

Adamczewska

Słowikowska-Hilczer

Walczak-Jędrzejowska

2022

Life

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The steroidogenic cells in the testicle, Leydig cells, located in the interstitial compartment, play a vital role in male reproductive tract development, maintenance of proper spermatogenesis, and overall male reproductive function. Therefore, their dysfunction can lead to all sorts of testicular pathologies. Spermatogenesis failure, manifested as azoospermia, is often associated with defective Leydig cell activity. Spermatogenic failure is the most severe form of male infertility, caused by disorders of the testicular parenchyma or testicular hormone imbalance. This review covers current progress in knowledge on Leydig cells origin, structure, and function, and focuses on recent advances in understanding how Leydig cells contribute to the impairment of spermatogenesis.

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