Functional-Anatomical Studies of Neural Control of Heart Rate in Goldfish

Hornby, Pamela J.; Demski, Leo S.

doi:10.1159/000116585

Cited by 17 publications

(11 citation statements)

References 37 publications

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“…This would be a similar situation to that in certain mammals where CA-containing neurons in the caudal ventrolateral medulla are known to project to the (visceral afferent) nucleus tractus solitarius [Blessing et a!., 1981]. A role in control of autonomic function by catecholaminergic neurons in the medullary tegmentum of teleosts is indicated by studies where electrical stimulation of this region evokes profound changes in heart rate [Hornby and Demski, 1988]. This is interesting be cause of the role of the ventrolateral medulla, includ ing the A1 area, in control of cardiovascular function in mammals [Blessing and Reis, 1982].…”

Section: Th-and Dbh-ir Cell Bodiesmentioning

confidence: 72%

Distribution of Catecholamine-Synthesizing Enzymes in Goldfish Brains: Presumptive Dopamine and Norepinephrine Neuronal Organization

Hornby

Piekut²

1990

Brain Behav Evol

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The organization of presumptive dopamine- and norepinephrine-synthesizing neurons in the brains of goldfish is described by using antibodies to tyrosine hydroxylase (TH) and dopamine β-hydroxylase (DBH) with avidin-biotin immunocytochemical techniques. In the hindbrain, TH-immunoreactive (IR) and DBH-IR cell bodies are located together in the following three regions: (1) dorsomedial medulla in the post-obecular region, (2) medullary tegmentum from the level of the greatest expansion of the vagal lobes to the medullospinal transition, and (3) isthmal tegmentum dorsolateral to the medial longitudinal fasciculus. Elsewhere in the brain, TH-IR neurons were visualized in eight distinct forebrain neuronal groups; DBH-IR cell bodies were not observed. Fibers and terminals IR for TH and DBH were most dense in forebrain periventricular regions, i.e. adjacent to the third ventricle, and specifically around the lateral and preoptic recesses. In the telencephalon, a dense innervation of TH- and DBH-IR fibers was noted within the area dorsalis, pars lateralis and pars dorsalis. Within the area dorsalis, pars centralis TH-IR fibers were dense; DBH-IR fibers were not visualized in this region. The presence of both dopamine- and norepinephrine-synthesizing neurons in the isthmal and medullary tegmentum and in the dorsomedial medulla provides evidence indicating that these regions are homologous to the locus ceruleus, medullary reticular nucleus and area postrema, respectively, in tetrapod brains. In addition, the remarkably dense innervation of TH-IR and DBH-IR fibers and terminals in periventricular regions of the hypothalamus and within the telencephalon suggests that there are potential similarities in the catecholaminergic innervation of forebrain regions of teleost and mammalian brains.

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Section: Th-and Dbh-ir Cell Bodiesmentioning

confidence: 72%

Distribution of Catecholamine-Synthesizing Enzymes in Goldfish Brains: Presumptive Dopamine and Norepinephrine Neuronal Organization

Hornby

Piekut²

1990

Brain Behav Evol

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“…This aspect of the experimental design was motivated by previous literature [31], [32], which suggests that the direction (increase versus decrease) of HR responses (see below) to fear conditioning can depend on whether the animal perceives that it has some control on the outcome of CS+ during training. Any vocalizations emitted by the animal, which crossed a set threshold, were acquired by a high frequency microphone (model 9569, ACO Pacific Inc. USA) and filtered between 1 and 100 kHz.…”

Section: Methodsmentioning

confidence: 99%

Fear Conditioned Discrimination of Frequency Modulated Sweeps within Species-Specific Calls of Mustached Bats

Naumann

2010

PLoS ONE

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Social and echolocation vocalizations of bats contain different patterns of frequency modulations. An adult bat's ability to discriminate between various FM parameters, however, is not well established. Using changes in heart rate (HR) as a quantitative measure of associative learning, we demonstrate that mustached bats (Pteronotus parnellii) can be fear conditioned to linear frequency modulated (FM) sweeps typically centered at their acoustic fovea (∼60 kHz). We also show that HR is sensitive to a change in the direction of the conditional frequency modulation keeping all other parameters constant. In addition, a change in either depth or duration co-varied with FM rate is reflected in the change in HR. Finally, HR increases linearly with FM rate incremented by 0.1 kHz/ms from a pure tone to a target rate of 1.0 kHz/ms of the conditional stimulus. Learning is relatively rapid, occurring after a single training session. We also observed that fear conditioning enhances local field potential activity within the basolateral amygdala. Neural response enhancement coinciding with rapid learning and a fine scale cortical representation of FM sweeps shown earlier make FMs prime candidates for discriminating between different call types and possibly communicating socially relevant information within species-specific sounds.

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“…Exogenous GRP within the third ventricle may stimulate GRP neurons or other neurons that project their axons to the cardioventilatory centers within the brainstem (Le Mével et al, 2012). In the goldfish, functional-anatomical studies have demonstrated the existence of a neural pathway from the preoptic area to the dorsal motor nucleus of the vagus controlling concomitantly ventilation and ƒH (Hornby and Demski, 1988). The neurochemicals involved in this pathway were not determined.…”

Section: Discussionmentioning

confidence: 99%

Central ventilatory and cardiovascular actions of trout gastrin-releasing peptide (GRP) in the unanesthetized trout

et al. 2013

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SummaryGastrin-releasing peptide (GRP), a neuropeptide initially isolated from porcine stomach, shares sequence similarity with bombesin. GRP and its receptors are present in the brains and peripheral tissues of several species of teleost fish, but little is known about the ventilatory and cardiovascular effects of this peptide in these vertebrates. The goal of this study was to compare the central and peripheral actions of picomolar doses of trout GRP on ventilatory and cardiovascular variables in the unanesthetized rainbow trout. Compared to vehicle, intracerebroventricular (ICV) injection of GRP (1–50 pmol) significantly elevated the ventilation rate (ƒV) and the ventilation amplitude (VAMP), and consequently the total ventilation (VTOT). The maximum hyperventilatory effect of GRP (VTOT: +225%), observed at a dose of 50 pmol, was mostly due to its stimulatory action on VAMP (+170%) rather than ƒV (+20%). In addition, ICV GRP (50 pmol) produced a significant increase in mean dorsal aortic blood pressure (PDA) (+35%) and in heart rate (ƒH) (+25%). Intra-arterial injections of GRP (5–100 pmol) were without sustained effect on the ventilatory variables but produced sporadic and transient increases in ventilatory movement at doses of 50 and 100 pmol. At these doses, GRP elevated PDA by +20% but only the 50 pmol dose significantly increased HR (+15%). In conclusion, our study suggests that endogenous GRP within the brain of the trout may act as a potent neurotransmitter and/or neuromodulator in the regulation of cardio-ventilatory functions. In the periphery, endogenous GRP may act as locally-acting and/or circulating neurohormone with an involvement in vasoregulatory mechanisms.

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Functional-Anatomical Studies of Neural Control of Heart Rate in Goldfish

Cited by 17 publications

References 37 publications

Distribution of Catecholamine-Synthesizing Enzymes in Goldfish Brains: Presumptive Dopamine and Norepinephrine Neuronal Organization

Distribution of Catecholamine-Synthesizing Enzymes in Goldfish Brains: Presumptive Dopamine and Norepinephrine Neuronal Organization

Fear Conditioned Discrimination of Frequency Modulated Sweeps within Species-Specific Calls of Mustached Bats

Central ventilatory and cardiovascular actions of trout gastrin-releasing peptide (GRP) in the unanesthetized trout

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