Functional Anatomical Evidence for Respiratory Rhythmogenic Function of Endogenous Bursters in Rat Medulla

Mellen, Nicholas; Mishra, Deepak

doi:10.1523/jneurosci.5510-09.2010

Cited by 22 publications

(19 citation statements)

References 50 publications

(74 reference statements)

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“…The finding that V T /T I was lower in female than in male mice suggests that females have lower respiratory drive at rest. Whether females have lower input from carotid body chemoafferents or lower activity of brainstem circuitry controlling timing between breaths (Mellen and Mishra, 2010) is not known.…”

Section: Discussionmentioning

confidence: 99%

Hypoxia-induced ventilatory responses in conscious mice: Gender differences in ventilatory roll-off and facilitation

Palmer¹,

May²,

deRonde³

et al. 2013

Respiratory Physiology & Neurobiology

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The aim of this study was to compare the ventilatory responses of C57BL6 female and male mice during a 15 min exposure to a hypoxic-hypercapnic (H-H) or a hypoxic (10% O2, 90% N2) challenge and subsequent return to room air. The ventilatory responses to H-H were similar in males and females whereas there were pronounced gender differences in the ventilatory responses during and following hypoxic challenge. In males, the hypoxic response included initial increases in minute volume via increases in tidal volume and frequency of breathing. These responses declined substantially (roll-off) during hypoxic exposure. Upon return to room-air, relatively sustained increases in these ventilatory parameters (short-term potentiation) were observed. In females, the initial responses to hypoxia were similar to those in males whereas roll-off was greater and post-hypoxia facilitation was smaller than in males. The marked differences in ventilatory roll-off and post-hypoxia facilitation between female and male C57BL6 mice provide evidence that gender is of vital importance to ventilatory control.

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Section: Discussionmentioning

confidence: 99%

Hypoxia-induced ventilatory responses in conscious mice: Gender differences in ventilatory roll-off and facilitation

Palmer¹,

May²,

deRonde³

et al. 2013

Respiratory Physiology & Neurobiology

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“…However, a rather complex picture has emerged regarding their intrinsic properties. PreBötC pacemakers have been found to show considerable variability in the range of interburst and intraburst frequencies, the amplitude of the plateau potential underlying bursting firing, and the voltage trajectory of this plateau [5,[80][81][82][83][84][85][86]. A biophysical and pharmacological characterization of their intrinsic properties have shown us that preBötC pacemakers can be grouped into two major groups: those that rely on the INap and those that rely on a Ca2+-activated non-specific cationic current [ICAN] [5,82,84,86].…”

Section: Role Of Pacemakers Can Be State-dependent: An Example Of Thementioning

confidence: 99%

Pacemaker Neurons and Neuronal Networks in Health and Disease

Peña‐Ortega¹

2012

Advances in Clinical Neurophysiology

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“…Although a similar effect is caused when embedded in the network, the same current injection evokes a much smaller membrane potential deflection (right panel). The injected hyperpolarizing pulse is schematically shown in blue below the trace (-DC) under a variety of conditions, not only in in vitro slice preparations [22][23][24][25][26] but also in the so-called in situ preparation [27]. The activity pattern of autonomously active neurons can range from autonomously spiking to weak, irregular spiking and to regular bursting.…”

Section: Cellular Mechanisms Of Bursting In the Respiratory Networkmentioning

confidence: 99%

The role of spiking and bursting pacemakers in the neuronal control of breathing

et al. 2011

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Breathing is controlled by a distributed network involving areas in the neocortex, cerebellum, pons, medulla, spinal cord, and various other subcortical regions. However, only one area seems to be essential and sufficient for generating the respiratory rhythm: the preBötzinger complex (preBötC). Lesioning this area abolishes breathing and following isolation in a brain slice the preBötC continues to generate different forms of respiratory activities. The use of slice preparations led to a thorough understanding of the cellular mechanisms that underlie the generation of inspiratory activity within this network. Two types of inward currents, the persistent sodium current (I NaP ) and the calcium-activated nonspecific cation current (I CAN ), play important roles in respiratory rhythm generation. These currents give rise to autonomous pacemaker activity within respiratory neurons, leading to the generation of intrinsic spiking and bursting activity. These membrane properties amplify as well as activate synaptic mechanisms that are critical for the initiation and maintenance of inspiratory activity. In this review, we describe the dynamic interplay between synaptic and intrinsic membrane properties in the generation of the respiratory rhythm and we relate these mechanisms to rhythm generating networks involved in other behaviors.

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Functional Anatomical Evidence for Respiratory Rhythmogenic Function of Endogenous Bursters in Rat Medulla

Abstract: Endogenous burster neurons (EBs

Cited by 22 publications

References 50 publications

Hypoxia-induced ventilatory responses in conscious mice: Gender differences in ventilatory roll-off and facilitation

Hypoxia-induced ventilatory responses in conscious mice: Gender differences in ventilatory roll-off and facilitation

Pacemaker Neurons and Neuronal Networks in Health and Disease

The role of spiking and bursting pacemakers in the neuronal control of breathing

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