Functional Analysis of the Schizophrenia Associated Gene As3mt in Sh-Sy5y Neuroblastoma Cells

Washer, Sam; Burrage, Joe; Mill, Jonathan; Jeffries, Aaron R.; Dempster, Emma

doi:10.1016/j.euroneuro.2017.08.365

Cited by 1 publication

(1 citation statement)

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“…Similar research was conducted for important SZ candidate genes encoding arsenite methyltransferase (AS3MT). AS3MT is the most statistically significant locus outside the major histocompatibility complex (MHC) region associated with SZ [21]. A human-specific isoform (AS3MTd2d3) lacks AS3MT activity and is more abundant in SZ individuals than in controls [22].…”

Section: Neuroblastoma Modelmentioning

confidence: 99%

Cellular Models in Schizophrenia Research

Abashkin

Kurishev

Карпов

et al. 2021

IJMS

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Schizophrenia (SZ) is a prevalent functional psychosis characterized by clinical behavioural symptoms and underlying abnormalities in brain function. Genome-wide association studies (GWAS) of schizophrenia have revealed many loci that do not directly identify processes disturbed in the disease. For this reason, the development of cellular models containing SZ-associated variations has become a focus in the post-GWAS research era. The application of revolutionary clustered regularly interspaced palindromic repeats CRISPR/Cas9 gene-editing tools, along with recently developed technologies for cultivating brain organoids in vitro, have opened new perspectives for the construction of these models. In general, cellular models are intended to unravel particular biological phenomena. They can provide the missing link between schizophrenia-related phenotypic features (such as transcriptional dysregulation, oxidative stress and synaptic dysregulation) and data from pathomorphological, electrophysiological and behavioural studies. The objectives of this review are the systematization and classification of cellular models of schizophrenia, based on their complexity and validity for understanding schizophrenia-related phenotypes.

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Section: Neuroblastoma Modelmentioning

confidence: 99%