“…As such, given BG involvement in voluntary movement and high-order aspects of motor control ( Groenewegen, 2003 ), structural and functional changes in BG were often associated with greater disease severity ( Sharma et al, 2013 ; Menke et al, 2018 ; Abidi et al, 2020 ; Bharti et al, 2022 ; Li et al, 2022 ), worsening of clinical symptoms, including greater disability and motor decline ( Sharma et al, 2013 ; Bharti et al, 2022 ), as well as faster disease progression ( Basaia et al, 2020 ; Tae et al, 2020 ), and shorter survival ( Westeneng et al, 2015 ; Zhang J. Q. et al, 2017 ).…”