Functional alteration patterns of default mode networks: comparisons of normal aging, amnestic mild cognitive impairment and Alzheimer's disease

Cha, Jung-Ho; Jo, Hang Joon; Kim, Hee Jin; Seo, Sang Won; Kim, Han‐Soo; Yoon, Uicheul; Park, Hyunjin; Na, Duk L.; Lee, Jongmin

doi:10.1111/ejn.12177

Cited by 54 publications

(61 citation statements)

References 53 publications

(86 reference statements)

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“…These findings indicated that the visual network deficits might be due to the consequence of the disease, meanwhile, inefficiently visual network activation might interfere the following higher cognitive processing in AD patients. Many fMRI studies have reported decreased activity of the default network in MCI [Cha et al, ; Jin et al, ; Zhu et al, ] and AD [Brier et al, ; Greicius et al, ; Wang et al, ; Zhou et al, ]. In this MCI‐ and AD‐related meta‐analyses, we found most of the decreased regions located in the posterior aspect of the default network, these parts were considered to be related to memory retrieval [Buckner et al, ] and played neurodegenerative roles during cognitive decline [Jacobs et al, ].…”

Section: Discussionmentioning

confidence: 50%

Toward systems neuroscience in mild cognitive impairment and Alzheimer's disease: A meta‐analysis of 75 fMRI studies

Hou

Liu

et al. 2014

Human Brain Mapping

166

125

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Most of the previous task functional magnetic resonance imaging (fMRI) studies found abnormalities in distributed brain regions in mild cognitive impairment (MCI) and Alzheimer's disease (AD), and few studies investigated the brain network dysfunction from the system level. In this meta-analysis, we aimed to examine brain network dysfunction in MCI and AD. We systematically searched task-based fMRI studies in MCI and AD published between January 1990 and January 2014. Activation likelihood estimation meta-analyses were conducted to compare the significant group differences in brain activation, the significant voxels were overlaid onto seven referenced neuronal cortical networks derived from the resting-state fMRI data of 1,000 healthy participants. Thirty-nine task-based fMRI studies (697 MCI patients and 628 healthy controls) were included in MCI-related meta-analysis while 36 task-based fMRI studies (421 AD patients and 512 healthy controls) were included in AD-related meta-analysis. The meta-analytic results revealed that MCI and AD showed abnormal regional brain activation as well as large-scale brain networks. MCI patients showed hypoactivation in default, frontoparietal, and visual networks relative to healthy controls, whereas AD-related hypoactivation mainly located in visual, default, and ventral attention networks relative to healthy controls. Both MCI-related and AD-related hyperactivation fell in frontoparietal, ventral attention, default, and somatomotor networks relative to healthy controls. MCI and AD presented different pathological while shared similar compensatory large-scale networks in fulfilling the cognitive tasks. These system-level findings are helpful to link the fundamental declines of cognitive tasks to brain networks in MCI and AD.

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Section: Discussionmentioning

confidence: 50%

Toward systems neuroscience in mild cognitive impairment and Alzheimer's disease: A meta‐analysis of 75 fMRI studies

Hou

Liu

et al. 2014

Human Brain Mapping

166

125

View full text Add to dashboard Cite

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“…However, in our study, no condition showed any correlation with MMSE scores. Different regional FC correlation of the DMN with MMSE has been noted and is probably lower the significant correlation of average FC in the whole DMN in our study (Cha et al 2013). MOCA is another validated tool for the detection of cognitive impairment in MCI and early AD and a higher score indicates a healthier condition (Nasreddine et al 2005).…”

Section: Discussioncontrasting

confidence: 42%

The effect of network template from normal subjects in the detection of network impairment

Chun-Chao¹,

Shang-Hua²,

Ching-Po³

2016

Acta Neurobiologiae Experimentalis

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This study aimed to provide a simple way to approach group differences by independent component analysis when researching functional connectivity changes of resting-state network in brain disorders. We used baseline resting state functional magnetic resonance imaging from the Alzheimer's disease neuroimaging initiative dataset and performed independent component analysis based on different kinds of subject selection, by including two downloaded templates and single-subject independent component analysis method. All conditions were used to calculate the functional connectivity of the default mode network, and to test group differences and evaluate correlation with cognitive measurements and hippocampal volume. The default mode network functional connectivity results most fitting clinical evaluations were from templates based on young healthy subjects and the worst results were from heterogeneous or more severe disease groups or single-subject independent component analysis method. Using independent component analysis network maps derived from normal young subjects to extract all individual functional connectivities provides significant correlations with clinical evaluations.

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“…Within the specific networks described above, the intrinsic functional connectivity was significantly reduced in aMCI patients compared to HE between SUB and the posterior cingulate, right ventromedial prefrontal, and left superior frontal cortex, while no decreased connectivity was found within the CA1 and CA2/3/4/DG networks. Previous studies assessing changes in intrinsic connectivity in AD reported discrepant findings but decreased connectivity within the DMN, and more specifically between the hippocampus and the posterior cingulate cortex was the most consistent finding across studies [Binnewijzend et al, ; Cha et al, ; Chhatwal et al, ; Damoiseaux et al, ; Greicius et al, ; Jones et al, ; Schwindt et al, ; Wu et al, ; Zhou et al, ]. Additionally, previous seed‐based works reported reduced connectivity between the hippocampus and the medial prefrontal, anterior cingulate and temporal cortex, and the cuneus/precuneus in AD [Allen et al, ; Wang et al, ] while the hippocampus was described as disconnected from the inferior parietal and medial prefrontal cortex in MCI [Das et al, ].…”

Section: Discussionmentioning

confidence: 79%

Intrinsic connectivity of hippocampal subfields in normal elderly and mild cognitive impairment patients

Flores

Mutlu

Bejanin

et al. 2017

Human Brain Mapping

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Hippocampal connectivity has been widely described but connectivity specificities of hippocampal subfields and their changes in early AD are poorly known. The aim of this study was to highlight hippocampal subfield networks in healthy elderly (HE) and their changes in amnestic patients with mild cognitive impairment (aMCI). Thirty-six HE and 27 aMCI patients underwent resting-state functional MRI scans. Specific intrinsic connectivity of bilateral CA1, SUB (subiculum), and CA2/3/4/DG was identified in HE (using seeds derived from manually delineation on high-resolution scans) and compared between HE and aMCI. Compared to the other subfields, CA1 was more strongly connected to the amygdala and occipital regions, CA2/3/4/DG to the left anterior cingulate cortex, temporal, and occipital regions, and SUB to the angular, precuneus, putamen, posterior cingulate, and frontal regions. aMCI patients showed reduced connectivity within the SUB network (with frontal and posterior cingulate regions). Our study highlighted for the first time three specific and distinct hippocampal subfield functional networks in HE, and their alterations in aMCI. These findings are important to understand AD specificities in both cognitive deficits and lesion topography, given the role of functional connectivity in these processes. Hum Brain Mapp 38:4922-4932, 2017. © 2017 Wiley Periodicals, Inc.

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Functional alteration patterns of default mode networks: comparisons of normal aging, amnestic mild cognitive impairment and Alzheimer's disease

Cited by 54 publications

References 53 publications

Toward systems neuroscience in mild cognitive impairment and Alzheimer's disease: A meta‐analysis of 75 fMRI studies

Toward systems neuroscience in mild cognitive impairment and Alzheimer's disease: A meta‐analysis of 75 fMRI studies

The effect of network template from normal subjects in the detection of network impairment

Intrinsic connectivity of hippocampal subfields in normal elderly and mild cognitive impairment patients

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