Functional adrenergic receptor polymorphisms and idiopathic orthostatic intolerance

Winker, Robert; Barth, Alfred; Valic, Eva; Maier, Richard; Osterode, W.; Pilger, Alexander; Rüdiger, H. W.

doi:10.1007/s00420-005-0605-y

Cited by 17 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furlan et al found higher LF/HF ratios in OI patients compared with controls in supine phase and during tilt, suggesting a hyperadrenergic state. 40 Also, our observed LF/HF ratios at first survey before training were notably higher in both positions compared with known normal values 26,41 and compared to controls 42 Pϭ0.001). In addition, we noted a reduction of total peripheral resistance after training (Table 5), which suggests a decrease of sympathetic activity.…”

Section: Discussionsupporting

confidence: 46%

Endurance Exercise Training in Orthostatic Intolerance

et al. 2005

View full text Add to dashboard Cite

Abstract-Orthostatic intolerance is a syndrome characterized by chronic orthostatic symptoms of light-headedness, fatigue, nausea, orthostatic tachycardia, and aggravated norepinephrine levels while standing. The aim of this study was to assess the protective effect of exercise endurance training on orthostatic symptoms and to examine its usefulness in the treatment of orthostatic intolerance. 2768 military recruits were screened for orthostatic intolerance by questionnaire. Tilt-table testing identified 36 cases of orthostatic intolerance out of the 2768 soldiers. Subsequently, 31 of these subjects with orthostatic intolerance entered a randomized, controlled trial. The patients were allocated randomly to either a "training" (3 months jogging) or a "control" group. The influence of exercise training on orthostatic intolerance was assessed by determination of questionnaire scores and tilt-table testing before and after intervention. After training, only 6 individuals of 16 still had orthostatic intolerance compared with 10 of 11 in the control group. The Fisher exact test showed a highly significant difference in diagnosis between the 2 groups (Pϭ0.008) at the end of the study. Analysis of the questionnaire-score showed significant interaction between time and group (Pϭ0.001). The trained subjects showed an improvement in the average symptom score from 1.79Ϯ0.4 to 1.04Ϯ0.4, whereas the control subjects showed no significant change in average symptom score (2.09Ϯ0.6 and 2.14Ϯ0.5, respectively). Our data demonstrate that endurance exercise training leads to an improvement of symptoms in the majority of patients with orthostatic intolerance. Therefore, we suggest that endurance training should be considered in the treatment of orthostatic intolerance patients.

show abstract

Section: Discussionsupporting

confidence: 46%

Endurance Exercise Training in Orthostatic Intolerance

et al. 2005

View full text Add to dashboard Cite

show abstract

“…A relationship between OH and mitochondrial DNA mutations was once reported in three families with idiopathic OH [15] . Orthostatic intolerance is also associated with a Gly49 polymorphism of the beta1 receptor gene [35] . Consistent with our results, Tabara et al [19] reported no association between polymorphisms of genes encoding the key components of the traditional RAS pathway and OH in a population-based study.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of angiotensin-converting enzyme (ACE) and ACE2 are not associated with orthostatic blood pressure dysregulation in hypertensive patients

Fan

Wang

et al. 2009

Acta Pharmacol Sin

View full text Add to dashboard Cite

Aim: The genetic background of orthostatic blood pressure dysregulation remains poorly understood. Since the renin-angiotensin system plays an important role in blood pressure regulation and response to position change, we hypothesized that angiotensin-converting enzyme (ACE) and ACE2 genetic polymorphisms might contribute, at least partially, to orthostatic blood pressure dysregulation in hypertensive patients. Methods: Two tag single nucleotide polymorphisms (SNPs) of ACE2 and ACE I/D were genotyped in 3630 untreated hypertensive patients and 826 normotensive subjects. Orthostatic hypertension was defined as an increase in systolic blood pressure of 20 mmHg or more and orthostatic hypotension as a drop in blood pressure of 20/10 mmHg or more within three minutes of assumption of upright posture. Results: Female and male patients had similar rates of orthostatic hypertension (16.5% vs 15.3%) and hypotension (22.5% vs 23.8%). No significant differences were detected in the minor allele frequency of ACE2 rs2106809, rs2285666, or ACE I/D in either female or male patients with orthostatic hypertension (15.1%, 22.7%, 19.6%, respectively), hypotension (13.8%, 25%, 16.5%), or normal orthostatic blood pressure response (14.4%, 21.9%, 15.8%) in additive, dominant or recessive models after adjustment for confounders (all P>0.05). The orthostatic changes in systolic and diastolic blood pressure were also comparable among patients carrying different genotypes. Similar results were observed in normotensive subjects. Conclusion: These data provide no support for the involvement of ACE or ACE2 in the genetic predisposition to orthostatic hypotension or hypertension.

show abstract

“…The following polymorphisms were studied in orthostatic hypotension and chronic orthostatic intolerance: the endothelin‐1 gene (insertion variant in the 5′ UTR), 15 beta‐1 adrenergic receptor gene (polymorphism beta‐1Gly49), 16 the human norepinephrine transporter gene (polymorphism Ala457Pro), 17 Gs protein alpha subunit (polymorphism T131C) 18 and G‐protein beta‐3 subunit (polymorphism C825T), 19 and SCNN1G gene encoding the gamma subunit of the amilorid‐sensitive epithelial sodium channel 19…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic Parameters and Heart Rate Variability during a Tilt Test in Relation to Gene Polymorphism of Renin‐Angiotensin and Serotonin System

Mitro

Mudráková

Mičková

et al. 2008

Pacing Clinical Electrophis

View full text Add to dashboard Cite

show abstract

Functional adrenergic receptor polymorphisms and idiopathic orthostatic intolerance

Abstract: Our current results suggest that the beta1Gly49 polymorphism is protective for IOI. This is likely one of several common genetic loci that may represent modifiers of IOI phenotypes.

Cited by 17 publications

References 37 publications

Endurance Exercise Training in Orthostatic Intolerance

Endurance Exercise Training in Orthostatic Intolerance

Polymorphisms of angiotensin-converting enzyme (ACE) and ACE2 are not associated with orthostatic blood pressure dysregulation in hypertensive patients

Hemodynamic Parameters and Heart Rate Variability during a Tilt Test in Relation to Gene Polymorphism of Renin‐Angiotensin and Serotonin System

Contact Info

Product

Resources

About