Functional Acute Renal Failure in a Patient with Carcinoid Syndrome

Couttenye, Marie-Madeleine; Verpooten, Gert A.; Daelemans, R.; Broe, Marc E. De

doi:10.1159/000184475

Cited by 5 publications

(3 citation statements)

References 6 publications

(8 reference statements)

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“… 24 , 30 , 31 However, only 3 cases of carcinoid syndrome were reported in more than 100 patients with renal carcinoid. 1 , 32 , 33 In addition, the pathogenesis of renal carcinoid is unclear, although neuroendocrine cells may be developed by metaplasia from tissue of intermediate mesoderm, no argyrophilic cells have been found in normal renal parenchyma. 34 It has been reported that well-differentiated neuroendocrine tumor of renal with teratomatous lesions may originate from bronchial endocrine (Kulchitsky) cells present among the basal parts of the bronchial and bronchiolar epithelium, 35 and primary well-differentiated neuroendocrine tumor of kidney is often associated with renal teratoma.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Pathological Features of Primary Renal Well-Differentiated Neuroendocrine Tumor

Hua¹,

Zhang²

2022

OTT

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Primary carcinoid tumor of the kidney is an extremely rare well-differentiated neuroendocrine tumor, which is generally a low-grade malignant cancer with a good prognosis. Carcinoid tumors are rarely found in the urinary system. Here, we report a 34-year-old woman with primary renal well-differentiated neuroendocrine tumor who underwent nephron sparing surgery and no evidence of recurrence or distant metastasis was found during routine follow-up. We searched the case of renal carcinoid with the search phrase “carcinoid [title] and kidney [title]” and “carcinoid [title] and renal [title]” using the PubMed and restricted the search to articles published in English since 2013. The clinical manifestations, age, sex, tumor size, location, gross pathology, light microscopy and immunohistochemistry were analyzed. A total of 28 cases of renal carcinoid were retrieved from PubMed. Higher proportion of positive labeling of CgA, Syn, NSE and CD56 are most valuable in the diagnosis of primary renal well-differentiated neuroendocrine tumor. At present, radical nephrectomy remains the gold standard in the curative-intent therapy for well-differentiated neuroendocrine carcinoma of kidney, in metastatic renal carcinoid, long-term use of octreotide may be an effective adjuvant therapy.

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Section: Discussionmentioning

confidence: 99%

Clinical and Pathological Features of Primary Renal Well-Differentiated Neuroendocrine Tumor

Hua¹,

Zhang²

2022

OTT

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“…The syndrome is characterized by flushing of the head and upper body, diarrhoea, and cardiac valve abnormalities [1]. Renal failure is rare in this condition [2]. We report a case of reversible and recurrent acute renal failure associated with a carcinoid crisis.…”

Section: Introductionmentioning

confidence: 99%

Acute renal failure associated with carcinoid crisis

Parry

Glover

Dudley

1996

Nephrology Dialysis Transplantation

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“…The description of kidney injury in the setting of neoplasms of neuroendocrine derivation or differentiation is lacking. Most described cases are without a histopathologic correlation, as a kidney biopsy was not performed, and decreased kidney function has been attributed to hemodynamic effects imparted by secreted, functional peptides 5, 6. In this article, we illustrate how CGA can specifically engorge and collect intracellularly within proximal tubules or precipitate and form intraluminal tubular casts resulting in clinically evident kidney injury.…”

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confidence: 99%

Chromogranin A Tubulopathy: Differing Histopathologic Patterns of Acute Tubular Injury in the Setting of Neuroendocrine Neoplasms

Sekulic

Waikar

Motwani

et al. 2019

Kidney International Reports

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Introduction Neoplasms of neuroendocrine derivation or differentiation may express specific peptides, some of which are capable of producing clinical symptomatology and others used as biomarkers: one such peptide being chromogranin A (CGA). Herein, we describe histopathologic changes present in kidney specimens from patients with such neoplasms, and illustrate 2 patterns of acute tubular injury (ATI) attributable to CGA. Methods Eleven patients with a history of a neoplasm of neuroendocrine derivation or differentiation and having histopathologic sampling of the kidney were retrospectively identified, 3 of whom had ATI with either engorgement of the proximal tubular epithelium by resorbed material or tubular cast formation. Results Two patterns of ATI were observed. One characterized by acutely injured proximal tubular cells engorged with resorption granules that expressed CGA via immunoperoxidase staining. Another pattern was characterized by intraluminal tubular cast material associated with ATI that did not exhibit restriction of immunoglobulin light chains (LCs), but immunoperoxidase staining for CGA revealed that the cast material was composed of the neuroendocrine-associated peptide. The level of serum CGA does not appear to necessarily equate to developing either of these 2 patterns of ATI. Conclusions Patients with a neoplasm of neuroendocrine derivation or differentiation may develop ATI, and in certain cases may be secondary to CGA renal tubular deposition.

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Functional Acute Renal Failure in a Patient with Carcinoid Syndrome

Cited by 5 publications

References 6 publications

Clinical and Pathological Features of Primary Renal Well-Differentiated Neuroendocrine Tumor

Clinical and Pathological Features of Primary Renal Well-Differentiated Neuroendocrine Tumor

Acute renal failure associated with carcinoid crisis

Chromogranin A Tubulopathy: Differing Histopathologic Patterns of Acute Tubular Injury in the Setting of Neuroendocrine Neoplasms

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