Functional activity of thyroid gland in male rats with acute and mild streptozotocin diabetes

Moiseyuk, I. V.; Derkach, K. V.; Ao, Shpakov

doi:10.1134/s0022093014040048

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…A reduced production of thyroid hormones may be the result of thyroid cells' resistance to TSH [12,32,33], which is due, primarily, to the weakening of TSH receptor sensitivity to TSH in thyrocytes and the changes in TSH-regulated intracellular signaling cascades. Earlier we have shown that in the thyroid gland of rats with acute DM1 the TSH-induced stimulation of adenylate cyclase activity was reduced [18,34]. Additionally, a decrease of sensitivity of the pituitary gland to TRH, indicated by the reduction of TRH-induced increase of the TSH level in the acute-D 1 + Buf group, can contribute to the decrease of thyroid hormones levels in DM1.…”

Section: Endocrine Researchmentioning

confidence: 99%

The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats

et al. 2015

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The functions of hypothalamic-pituitary-thyroid axis are attenuated in type 1 diabetes mellitus due to insulin deficiency. The use of intranasally administered insulin is of considerable interest for treatment of diabetes and cognitive disorders, but its effect on the thyroid system has not been investigated yet. We studied the influence of long-term treatment with intranasal insulin on the hypothalamic-pituitary-thyroid axis of nondiabetic rats and diabetic animals with streptozotocin models of acute and mild type 1 diabetes mellitus. This treatment was carried out for 28 days in acute (daily does of 0.3, 0.6, and 1.5?IU of insulin per rat) and for 135 days in mild diabetes (daily dose of 0.45?IU/rat). Nondiabetic rats were treated in a similar manner. Intranasal insulin in both models of diabetes resulted in the improvement of thyroid status; manifested as increase of thyroid hormones levels and restoration of response to thyroliberin. In acute diabetes, a daily dose of 0.6?IU/rat was the most effective. Twenty eight days treatment of nondiabetic rats with intranasal insulin at a dose of 0.3?IU/rat resulted in a significant increase of free and total thyroxine levels. Longer treatment of rats with mild diabetes and nondiabetic animals significantly increased thyrotropin level. Thus, long-term intranasal insulin treatment restored the hypothalamic-pituitary-thyroid axis function in type 1 diabetes, but led to a significant increase in the thyrotropin level, which must be considered when designing a strategy for the use of intranasal insulin in clinical applications.

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Section: Endocrine Researchmentioning

confidence: 99%

The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats

et al. 2015

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“…In addition to pancreatic hormones (insulin and glucagon), other counter regulatory hormones like thyroid hormones (THs) have important influences on glucose homeostasis. Diabetes is associated with impaired hypothalamic-pituitary-thyroid (HPT) axis, decreased secretion of thyrotropin releasing hormone (TRH), thyroid stimulating hormone (TSH) as well as reduced thyroid function and growth [6]. Insulin secretion is under direct control of THs.…”

Section: Introductionmentioning

confidence: 99%

Fenugreek, A Potent Hypoglycaemic Herb Can Cause Central Hypothyroidism Via Leptin – A Threat To Diabetes Phytotherapy

Majumdar

Chakraborty

Mitra

et al. 2017

Exp Clin Endocrinol Diabetes

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Fenugreek (, a medicinal herb with potent antihyperglycaemic and hypoglycaemic effects, is used to treat diabetes. This study is aimed to explore the interaction of fenugreek seed extract (FSE) and HPT (hypothalamic-pituitary-thyroid) axis in context of leptin secretion which have important role in normal and type-1 diabetic subjects. FSE (confirmed to contain trigonelline, diosgenin, 4 hydroxyisoleucine) was gavaged (0.25 gm/kg body weight/day) to normal and alloxan-induced type-1 diabetic rats for 4 weeks. Expression of hypothalamic prepro-TRH (Thyrotropin releasing hormone) mRNA, serum levels of TRH, TSH (Thyroid stimulating hormone), fT, fT, insulin, leptin, glucose; thyroperoxidase activity and growth of thyroid gland, food intake, adiposity index were also studied FSE significantly down regulated prepro-TRH mRNA expression; decreased serum TRH, TSH, fT, fT levels, and regressed thyroid gland in FSE-fed normal and diabetic rats than those observed in normal diet-fed control and diabetic rats. FSE decreased (p<0.005-0.001) adiposity index and leptin secretion, increased food intake and body weight in all FSE-fed rats. FSE improved insulin secretion, decreased glucose level but impaired HPT axis in diabetic rats, indicating insulin-independent central hypothyroidism. Results suggested that the dominant signal to hypothalamus suppressing HPT axis is the fall in leptin level which i resulted from decreased adiposity index following FSE feeding. Fenugreek simultaneously having hypoglycaemic and hypothyroidal actions raises questions whether it can be safely used to treat diabetes and/or hyperthyroidism as was suggested by many workers.

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Molecular Mechanisms of the Relationship between Thyroid Dysfunctions and Diabetes Mellitus

Шпаков

2018

J Evol Biochem Phys

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Functional activity of thyroid gland in male rats with acute and mild streptozotocin diabetes

Cited by 4 publications

References 33 publications

The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats

The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats

Fenugreek, A Potent Hypoglycaemic Herb Can Cause Central Hypothyroidism Via Leptin – A Threat To Diabetes Phytotherapy

Molecular Mechanisms of the Relationship between Thyroid Dysfunctions and Diabetes Mellitus

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