Functional Activity of Neutrophils in Diabetes Mellitus and Coronary Heart Disease: Role of Myeloperoxidase in the Development of Oxidative Stress

Gorudko, Irina V.; Kostevich, Valeria A.; Sokolov, A. V.; Shamova, Ekaterina V.; Buko, I. V.; Konstantinova, E; Vasiliev, V. B.; Черенкевич, С. Н.; Панасенко, О. М.

doi:10.1007/s10517-012-1865-7

Cited by 31 publications

(22 citation statements)

References 8 publications

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“…While "parainflammation" may help to maintain homeostasis, persistent and prolonged diabetes may to occlusion and non-perfusion (Valle et al, 2013). It is interesting to note that in the advanced stages of diabetic retinopathy, the systemic neutrophil count is increased (Woo et al, 2011) and these cells express higher levels of myeloperoxidase and produce more hydrogen peroxide compared to cells from non-diabetic controls (Gorudko et al, 2012). Circulating monocytes are also activated in T1D patients (Josefsen et al, 1994) and they express elevated adhesion molecules (Bouma et al, 2004) with concomitant binding to endothelium (Devaraj et al, 2011).…”

Section: D Inflammation and Immune Cell Activation In Diabetic Retimentioning

confidence: 99%

The progress in understanding and treatment of diabetic retinopathy

Stitt

Curtis

Chen

et al. 2016

Progress in Retinal and Eye Research

776

657

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Section: D Inflammation and Immune Cell Activation In Diabetic Retimentioning

confidence: 99%

The progress in understanding and treatment of diabetic retinopathy

Stitt

Curtis

Chen

et al. 2016

Progress in Retinal and Eye Research

776

657

View full text Add to dashboard Cite

“…-Elevated levels of soluble forms of CAMs -Activated monocytes in diabetic subjects [210][211][212] -Increased circulating neutrophil levels in late-stage diabetic retinopathy [213] The neutrophils express more myeloperoxidase (MPO), and generate greater amounts of cytotoxic hydrogen peroxide in diabetic than in non-diabetic subjects [214].…”

Section: Inflammationmentioning

confidence: 99%

Biomarkers in Diabetic Retinopathy

et al. 2015

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■ AbstractThere is a global diabetes epidemic correlating with an increase in obesity. This coincidence may lead to a rise in the prevalence of type 2 diabetes. There is also an as yet unexplained increase in the incidence of type 1 diabetes, which is not related to adiposity. Whilst improved diabetes care has substantially improved diabetes outcomes, the disease remains a common cause of working age adult-onset blindness. Diabetic retinopathy is the most frequently occurring complication of diabetes; it is greatly feared by many diabetes patients. There are multiple risk factors and markers for the onset and progression of diabetic retinopathy, yet residual risk remains. Screening for diabetic retinopathy is recommended to facilitate early detection and treatment. Common biomarkers of diabetic retinopathy and its risk in clinical practice today relate to the visualization of the retinal vasculature and measures of glycemia, lipids, blood pressure, body weight, smoking, and pregnancy status. Greater knowledge of novel biomarkers and mediators of diabetic retinopathy, such as those related to inflammation and angiogenesis, has contributed to the development of additional therapeutics, in particular for late-stage retinopathy, including intra-ocular corticosteroids and intravitreal vascular endothelial growth factor inhibitors ('anti-VEGFs') agents. Unfortunately, in spite of a range of treatments (including laser photocoagulation, intraocular steroids, and anti-VEGF agents, and more recently oral fenofibrate, a PPAR-alpha agonist lipid-lowering drug), many patients with diabetic retinopathy do not respond well to current therapeutics. Therefore, more effective treatments for diabetic retinopathy are necessary. New analytical techniques, in particular those related to molecular markers, are accelerating progress in diabetic retinopathy research. Given the increasing incidence and prevalence of diabetes, and the limited capacity of healthcare systems to screen and treat diabetic retinopathy, there is need to reliably identify and triage people with diabetes. Biomarkers may facilitate a better understanding of diabetic retinopathy, and contribute to the development of novel treatments and new clinical strategies to prevent vision loss in people with diabetes. This article reviews key aspects related to biomarker research, and focuses on some specific biomarkers relevant to diabetic retinopathy.

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“…[10,11] Highly reactive hypohalous acids formed in the system of Н 2 О 2 -MPО and their derivatives -secondary RHS along with ROS and reactive nitrogen species -determine the efficacy of the cellular response under induction and maintenance of inflammation, [10] thus providing the interrelation between oxidative and halogenating stress. [11] The main source of ROS and RHS is primed neutrophilic leukocytes [12] depositing MPO in azurophilic granules and secreting the enzyme into extracellular media through degranulation. [10] In our previous studies we found the elevated level of MPO activity is associated with high intensiveness of degranulation and destruction of leukocytes in IS of asthma patients with AHR to hypoosmotic and cold triggers.…”

Section: Introductionmentioning

confidence: 99%

Peculiarities of Airway Inflammation and Lipid Peroxidation in the Development of Hyperosmotic Airway Hyperresponsiveness in Patients with Asthma

Pirogov¹,

Prikhodko²,

Perelman³

et al. 2016

Int J Biomed

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The aim of our study was to evaluate the role of airway cellular inflammation and the lipid peroxidation level in the development of airway hyperresponsiveness (AHR) to inhalation of hypertonic saline (IHS). Methods and Results:The study included the estimation of inflammatory-cellular composition, intracellular concentration of myeloperoxidase (MPO) in induced sputum (IS), serum levels of lipid hydroperoxides (LHP), ceruloplasmin, and vitamin E in 29 patients with asthma and 12 healthy persons. AHR to IHS was assessed by spirometry after 3-min IHS via ultrasonic nebulizer. Patients with asthma had higher indices of leukocytes destruction and cytolysis intensity with the increased leukocyte count in IS. Maximum values of neutrophils cytolysis intensity and leukocytic MPO were found in IS of the patients with AHR to IHS. After the bronchial provocation, serum concentration of LHP was higher in these patients in comparison with the patients without the AHR and control groups. In addition, patients with asthma had lower level of antioxidants than healthy subjects.Conclusion: Marked inflammation involving MPO-activated leukocytes and intensive lipid peroxidation underlie the excessive airway response to IHS. (Int J Biomed. 2016; 6(4):259-264.)

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Functional Activity of Neutrophils in Diabetes Mellitus and Coronary Heart Disease: Role of Myeloperoxidase in the Development of Oxidative Stress

Cited by 31 publications

References 8 publications

The progress in understanding and treatment of diabetic retinopathy

The progress in understanding and treatment of diabetic retinopathy

Biomarkers in Diabetic Retinopathy

Peculiarities of Airway Inflammation and Lipid Peroxidation in the Development of Hyperosmotic Airway Hyperresponsiveness in Patients with Asthma

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