Functional activity of murine intestinal mucosal cells is regulated by the glucagon-like peptide-1 receptor

Kedees, Mamdouh H.; Guz, Yelena; Grigoryan, Marine; Teitelman, Gladys

doi:10.1016/j.peptides.2013.07.022

Cited by 30 publications

(36 citation statements)

References 33 publications

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“…However, the important effect of liraglutide on ApoB48 metabolism suggests that it may have a direct effect on the intestine. The presence of GLP-1 receptors in the intestinal tissue reinforces the hypothesis of a possible direct action in the intestine, [30][31][32] and the results that we observed in mice also suggest that liraglutide may have a direct effect in the intestine. Indeed, a short period of treatment with liraglutide induced a significant reduction in postprandial lipidemia in mice, and in vitro liraglutide reduced the expression of genes involved in the biosynthesis of chylomicrons, such as ApoB48, MTP, or DGAT1 in the intestine.…”

Section: Discussionsupporting

confidence: 88%

Liraglutide Reduces Postprandial Hyperlipidemia by Increasing ApoB48 (Apolipoprotein B48) Catabolism and by Reducing ApoB48 Production in Patients With Type 2 Diabetes Mellitus

Vergès

Duvillard

Barros

et al. 2018

ATVB

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Objective-Treatment with liraglutide, a GLP-1 (glucagon-like peptide-1) agonist, has been shown to reduce postprandial lipidemia, an important feature of diabetic dyslipidemia. However, the underlying mechanisms for this effect remain unknown. This prompted us to study the effect of liraglutide on the metabolism of ApoB48 (apolipoprotein B48). Approach and Results-We performed an in vivo kinetic study with stable isotopes (D 8 -valine) in the fed state in 10 patients with type 2 diabetes mellitus before treatment and 6 months after the initiation of treatment with liraglutide (1.2 mg/d).We also evaluated, in mice, the effect of a 1-week liraglutide treatment on postload triglycerides and analysed in vitro on jejunum, the direct effect of liraglutide on the expression of genes involved in the biosynthesis of chylomicron.

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Section: Discussionsupporting

confidence: 88%

Liraglutide Reduces Postprandial Hyperlipidemia by Increasing ApoB48 (Apolipoprotein B48) Catabolism and by Reducing ApoB48 Production in Patients With Type 2 Diabetes Mellitus

Vergès

Duvillard

Barros

et al. 2018

ATVB

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“…It must contend with bombardment by a vast number of potential pathogenic bacteria, fungi, and viruses, while simultaneously maintaining homeostasis of a resident community of commensal organisms [16]. The epithelial surface of the intestine produces a diversity of antimicrobial peptides that help the bowel to meet its microbial challenges [17].…”

Section: Phylogeny Of Neuroimmune Interactionsmentioning

confidence: 99%

“…Paneth and other cells secrete α- and β-defensins, C-type lectins of the REG3 family, secretory phospholipase A 2 , and lysozyme when bacterial products activate receptors these cells express. The management of the secretion of these antimicrobial peptides is subject to endocrine and neurocrine regulation [16]. The gut thus has a powerful antimicrobial apparatus.…”

Section: Phylogeny Of Neuroimmune Interactionsmentioning

confidence: 99%

Enteric Neuronal Regulation of Intestinal Inflammation

Margolis

Gershon

2016

Trends in Neurosciences

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Recent research has highlighted the importance of the two-way interaction between the nervous and immune systems. This interaction is particularly important in the bowel because of the unique properties of this organ. The lumen of the gut is lined by a very large but remarkably thin surface that separates the body from the enteric microbiome. Immune defenses against microbial invasion are thus well developed, and neuroimmune interactions are important in regulating and integrating these defenses. Important concepts in the phylogeny of neuroimmunity, enteric neuronal and glial regulation of immunity, changes that occur in the enteric nervous system during inflammation, the fundamental role of serotonin (5-HT) in enteric neuroimmune mechanisms, and future perspectives are reviewed.

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“…This study investigated whether CEACAM2 regulates insulin secretion. We report here that CEACAM2 plays a role in insulin secretion via a mechanism implicating the release of the insulinotropic glucagon-like peptide-1 (GLP-1), an incretin that potentiates glucose-stimulated insulin secretion from pancreatic ␤-cells (11)(12)(13)(14)(15)(16)(17).…”

mentioning

confidence: 99%

Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2)

Ghanem¹,

Heinrich²,

Lester³

et al. 2016

Journal of Biological Chemistry

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Functional activity of murine intestinal mucosal cells is regulated by the glucagon-like peptide-1 receptor

Cited by 30 publications

References 33 publications

Liraglutide Reduces Postprandial Hyperlipidemia by Increasing ApoB48 (Apolipoprotein B48) Catabolism and by Reducing ApoB48 Production in Patients With Type 2 Diabetes Mellitus

Liraglutide Reduces Postprandial Hyperlipidemia by Increasing ApoB48 (Apolipoprotein B48) Catabolism and by Reducing ApoB48 Production in Patients With Type 2 Diabetes Mellitus

Enteric Neuronal Regulation of Intestinal Inflammation

Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2)

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