Functional Activity of Alveolar and Peripheral Cells in Patients with Human Acquired Immunodeficiency Syndrome and Pulmonary Tuberculosis

Bonecini-Almeida, Maria da Glória; Werneck-Barroso, Eduardo; Carvalho, Paula Baptista; Moura, Cristina Pereira de; Andrade, Elisabete; Hafner, Alice; Carvalho, Carlos Eduardo; Ho, John L.; Kritski, Afrânio Lineu; Morgado, Mariza G.

doi:10.1006/cimm.1998.1399

Cited by 22 publications

(6 citation statements)

References 35 publications

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“…(Geldmacher et al, 2008; Zhang et al, 1994) Similar defects have been observed in Mtb-specific CD4 T cells isolated from lung lavage samples of HIV infected individuals. (Bonecini-Almeida Mda et al, 1998; Kalsdorf et al, 2009) In addition, HIV co-infection alters the quality of the T cell response, resulting in reduced frequencies of polyfunctional T cells. (Day et al, 2008; Jambo et al, 2011; Kalsdorf et al, 2009)…”

Section: Hiv-tbmentioning

confidence: 99%

T Cell Susceptibility to HIV Influences Outcome of Opportunistic Infections

Saharia

Koup

2013

Cell

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During HIV infection, the timing of opportunistic infections is not always associated with severity of CD4 T cell depletion and different opportunistic pathogens reactivate at different CD4 T cell thresholds. Here we review how differences in the phenotype and function of pathogen-specific CD4 T cells influence susceptibility to HIV infection. By focusing on three common opportunistic infections (Mycobacterium tuberculosis, human papillomavirus, and cytomegalovirus) we examine how differential depletion of pathogen-specific CD4 T cells impacts the natural history of these pathogens in HIV infection. A broader understanding of this relationship can better inform treatment strategies against co-pathogens.

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Section: Hiv-tbmentioning

confidence: 99%

T Cell Susceptibility to HIV Influences Outcome of Opportunistic Infections

Saharia

Koup

2013

Cell

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“…IFN-γ is also necessary for the control of TB (35, 36) and has been the focus of multiple co-infection studies (7, 8, 11, 12). These studies conclude that HIV reduces IFN-γ production by M. tuberculosis -specific CD4 T cells in the periphery and airway.…”

Section: Discussionmentioning

confidence: 99%

“…HIV decreases IFN-γ mRNA production and proliferation by M. tuberculosis -specific T cells in the airways of AIDS patients with TB compared to individuals with active TB without AIDS (11, 12). HIV also reduces IFN-γ+TNF+IL-2+ polyfunctional BCG-specific CD4 T cells within the airways of BCG-vaccinated individuals relative to HIV-uninfected controls (13).…”

Section: Introductionmentioning

confidence: 99%

Monocyte-Derived IL-5 Reduces TNF Production byMycobacterium tuberculosis–specific CD4 T Cells during SIV/M. tuberculosisCoinfection

Diedrich

Mattila

Flynn

2013

The Journal of Immunology

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HIV-infected individuals are significantly more susceptible to tuberculosis (TB) than HIV-uninfected individuals. Although it is established that HIV reduces M. tuberculosis-specific T cell responses, the causes of this dysfunction are not known. We used the cynomolgus macaque model of TB to demonstrate that ex vivo SIV reduces the frequency of M. tuberculosis-specific TNF and IFN-γ producing T cells within 24hrs post-infection. In vivo, T cell IFN-γ responses in granulomas from animals with SIV/M. tuberculosis co-infection were lower than SIV-negative animals with active TB. The SIV effects on inhibition of T cell responses were primarily on antigen presenting cells and not the T cells directly. Specifically, reductions in the frequency of TNF-producing M. tuberculosis-specific CD4 T cells were caused, at least in part, by SIV-induced production of monocyte derived IL-5.

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“…Although a few studies have previously examined the functions of AM obtained from HIV-infected patients with active pulmonary TB [18,27], it is not clear if co-infection with these pathogens affects the ability of AM to respond to potent stimuli.…”

Section: Discussionmentioning

confidence: 99%