Functional activation in motor cortex reflects the direction and the degree of handedness

Dassonville, Paul; Zhu, Xiaohong; Uğurbil, Kâmil; Kim, Seong‐Gi; Ashe, James

doi:10.1073/pnas.94.25.14015

Cited by 262 publications

(203 citation statements)

References 32 publications

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“…A continuous relationship between degree of handedness and neuronal activation has previously been shown with unilateral motor tasks involving visually cued button presses (Dassonville et al, 1997;Singh et al, 1998). Our finding indicates that the attempt to switch handedness for writing has a wider impact on the functional neuroanatomy of the motor system that controls the hands, influencing even motor tasks that require little skill.…”

Section: Discussionmentioning

confidence: 52%

“…Although handedness has been attributed to genetic factors (Sun and Walsh, 2006), the exact basis and neuronal correlates remain to be determined. Several postmortem (Witelson and Kigar, 1992;White et al, 1994;Amunts et al, 1996), structural (Amunts et al, 2000;Good et al, 2001;Büchel et al, 2004;Herve et al, 2005Herve et al, , 2006, and functional magnetic resonance imaging (fMRI) studies (Kim et al, 1993;Dassonville et al, 1997;Singh et al, 1998;Solodkin et al, 2001;Klöppel et al, 2007) have shown structural and functional hemispheric asymmetries between adult rightand left-handers (for review, see Serrien et al, 2006;Sun and Walsh, 2006). However, on the basis of these studies, it is impossible to infer whether handedness-related differences are determinant or reflect a long-term consequence of actual hand use.…”

Section: Introductionmentioning

confidence: 99%

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Can Left-Handedness be Switched? Insights from an Early Switch of Handwriting

Klöppel¹,

Vongerichten²,

Eimeren³

et al. 2007

J. Neurosci.

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"Converted" left-handers are innately left-handed individuals forced as children to write with the right nondominant hand. We asked how a left-to-right handwriting switch shapes cortical sensorimotor representations of finger movements. In 16 adult converted lefthanders and age-matched groups of 16 consistent right-handers and 16 left-handers, we studied movement-related neuronal activity with functional magnetic resonance imaging while participants performed simple unimanual and bimanual movements with right and left index fingers. In converted left-handers, movement-related activity in the primary sensorimotor hand area (SM1) and caudal dorsal premotor cortex (PMd) of the nondominant left hemisphere correlated with the left-to-right shift in handedness. The more right-handed converted left-handers had become, the greater the sensorimotor activation in these areas. Between-group comparisons showed that the switch from left to right hand also reinforced movement representations in the dominant right hemisphere. In converted left-handers, the right inferior parietal cortex and lateral PMd were more active relative to consistent right or left-handers in all motor tasks. These results suggest two distinct neuronal correlates of handedness in human sensorimotor cortex. Although those in executive sensorimotor cortex (i.e., SM1 and adjacent PMd) depend on the hand used throughout life, those in higher-order sensorimotor areas (i.e., inferior parietal cortex and rostrolateral PMd) are invariant and thus cannot be switched to the nondominant hemisphere by educational training.

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Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Can Left-Handedness be Switched? Insights from an Early Switch of Handwriting

Klöppel¹,

Vongerichten²,

Eimeren³

et al. 2007

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…For upper limb movements, handedness-related asymmetries in cortical (e.g., Dassonville, Zhu, Ugurbil, Kim, & Ashe, 1997;Jancke et al, 1998;Kim et al, 1993;Viviani, Perani, Grassi, Bettinardi, & Fazio, 1998) and corticospinal activity (e.g., De Genarro et al, 2004;Triggs, Calvanio, & Levine, 1997;Triggs, Calvanio, Macdonell, Cros, & Chiappa, 1994) have been established as well as changes in brain activity in response to attentional manipulations (Johansen-Berg & Matthews, 2002). However, the relation between the neurophysiological correlates of these two factors has (to our knowledge) not been examined to date.…”

Section: Resultsmentioning

confidence: 96%

Laterally focused attention modulates asymmetric coupling in rhythmic interlimb coordination

Poel

Peper

Beek

2006

Psychological Research

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Peters (J Motor Behav 21:151-155, 1989; Interlimb coordination: neural, dynamical and cognitive constraints, Academic, Orlando, pp 595-615, 1994) suggested that expressions of handedness in bimanual coordination may be reflections of an inherent attentional bias. Indeed, previous results indicated that focusing attention on one of the limbs affected the relative phasing between the limbs in a manner comparable to the effects of hand dominance. The present study extended the comparison between the effects of attentional focus and handedness by testing their impact on the interactions between the limbs. Both lefthanded and right-handed participants performed rhythmic bimanual coordination tasks (in-phase and antiphase coordination), while directing attention to either limb. Using brief mechanical perturbations, the degree to which the limbs were influenced by each other was determined. The results revealed that the non-dominant limb was more strongly affected by the dominant limb than vice versa and that, in line with Peters' proposition, this handedness-related asymmetry in coupling strength was reduced when attention was focused on the non-dominant limb, thereby highlighting the potential relation between inherent (handednessrelated) asymmetries and voluntary attentional asymmetries. In contrast to previous findings, the (commonly observed) phase lead of the dominant limb was attenuated (rather than accrued) when attention was focused on this limb. This unexpected result was explained in terms of the observed attention-related difference in amplitude between the limbs.

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“…Absent or pathologically decreased task-based BOLD fMRI activation in the presence of a tumor or other resectable focal brain lesion, in the absence of a focal neurological deficit attributable to destruction of the eloquent cortical region that would be expected to produce a robust BOLD response, represents direct evidence of NVU (Hou et al, 2006;Ulmer et al, 2003;Zacà et al, 2014). Although some degree of asymmetry of task-based activation in the primary motor network has been reported in previous studies of normal volunteers (Dassonville et al, 1997;Jancke et al, 1998;Solodkin et al, 2001), the degree of asymmetry observed has been less substantial than what we observed in patients with gliomas, both in this small series and in prior publications that included larger patient series (Agarwal et al, 2015;Zacà et al, 2014). For this reason, .…”

Section: Discussionmentioning

confidence: 97%

Demonstration of Brain Tumor-Induced Neurovascular Uncoupling in Resting-State fMRI at Ultrahigh Field

et al. 2016

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To demonstrate in a small case series for the first time the phenomenon of brain tumor-related neurovascular uncoupling (NVU) in resting-state blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) at ultrahigh field (7T). Two de novo (i.e., untreated) brain tumor patients underwent both BOLD resting-state fMRI (rsfMRI) on a 7T MRI system and motor task-based BOLD fMRI at 3T. Ipsilesional (i.e., ipsilateral to tumor or IL) and contralesional (i.e., contralateral to tumor or CL) region of interest (ROI) analysis was performed on both 3T motor task-related general linear model-derived activation maps and on 7T rsfMRI independent component analysis (ICA)-derived sensorimotor network maps for each case. Asymmetry scores (ASs) were computed based on numbers of suprathreshold voxels in the IL and CL ROIs. In each patient, ASs derived from ROI analysis of suprathreshold voxels in IL and CL ROIs in task-related activation maps and rsfMRI ICA-derived sensorimotor component maps indicate greater number of suprathreshold voxels in contralesional than ipsilesional sensorimotor cortex in both maps. In patient 1, an AS of 0.2 was obtained from the suprathreshold Z-score spectrum (voxels with Z-scores >5.0) of the task-based activation map and AS of 1.0 was obtained from the suprathreshold Z-score spectrum (Z-scores >5.0) of the ICA-derived sensorimotor component map. Similarly, in patient 2, an AS of 1.0 was obtained from the suprathreshold Z-score spectrum (Z-scores >5.0) of the task-based activation map and an AS of 1.0 was obtained from the suprathreshold Z-score spectrum (Z-scores >5.0) of the ICA-derived sensorimotor component map. Overall, decreased BOLD signal was noted in IL compared with CL ROIs on both task-based activation maps and ultrahigh field resting-state maps, indicating the presence of NVU. We have demonstrated evidence of NVU on ultrahigh field 7T rsfMRI comparable with the findings on standard 3T motor task-based fMRI in both cases.

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Functional activation in motor cortex reflects the direction and the degree of handedness

Cited by 262 publications

References 32 publications

Can Left-Handedness be Switched? Insights from an Early Switch of Handwriting

Can Left-Handedness be Switched? Insights from an Early Switch of Handwriting

Laterally focused attention modulates asymmetric coupling in rhythmic interlimb coordination

Demonstration of Brain Tumor-Induced Neurovascular Uncoupling in Resting-State fMRI at Ultrahigh Field

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